The 3435T polymorphism in the ABCB1 gene and colchicine unresponsiveness in familial Mediterranean fever

Clinical and Experimental Rheumatology

Volumn 27, Issue 2 SUPPL.53, 2009, Pages

  Bezalel, Y ^a   Gershoni Baruch, Ruth ^a,b   Dagan, E ^a,c   Lidar, M ^d   Livneh, A ^d,e  

^a RAMBAM MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c UNIVERSITY OF HAIFA   (Israel)

^d HELLER INSTITUTE OF MEDICAL RESEARCH   (Israel)

^e TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; MULTIDRUG RESISTANCE PROTEIN 1;

CONTROLLED STUDY; DNA POLYMORPHISM; FAMILIAL MEDITERRANEAN FEVER; GENE MUTATION; GENOTYPE; HUMAN; LETTER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TREATMENT RESPONSE;

CASE-CONTROL STUDIES; COLCHICINE; DRUG RESISTANCE; FAMILIAL MEDITERRANEAN FEVER; FEMALE; HUMANS; MALE; P-GLYCOPROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; TUBULIN MODULATORS;

EID: 70350154314     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (10)

1. SOHAR E, GAFNI J, PRAS M, HELLER H: Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med 1967; 43: 227-253
2. ZEMER D, PRAS M, SOHAR E, MODAN M, CABILI S, GAFNI J: Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever. N Engl J Med 1986; 314: 1001-1005 (Pubitemid 16138694)
3. LIDAR M, SCHERRMANN JM, SHINAR Y et al.: Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterization. Semin Arthritis Rheum 2004; 33: 273-282
4. UEDA K, CORNWELL MM, GOTTESMAN MM et al.: The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun 1986; 141: 956-962
5. KLIMECKI WT, TAYLOR CW, DALTON WS: Inhibition of cell-mediated cytolysis and P-glycoprotein function in natural killer cells by verapamil isomers and cyclosporine A analogs. J Clin Immunol 1995; 15: 152-158
6. HITZL M, DRESCHER S, VAN DER KUIP H et al.: The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells. Pharmacogenetics 2001; 11: 293-298
7. KIMCHY-SARFATY C, OH JM, KIM IW et al.: A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science 2007; 315: 525-528
8. EICHELBAUM M, FROMM MF, SCHWAB M: Clinical aspects of the MDR1 (ABCB1) gene polymorphism. Ther Drug Monit 2004; 26: 180-185 (Pubitemid 38501215)
9. TUFAN A, BABAOGLU MO, AKDOGAN A et al.: Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever. J Rheumatol 2007; 34: 1540-1544
10. th International Congress on Systemic Autoinflammatory Diseases 2005; 25.