Bio-mimetic hollow scaffolds for long bone replacement

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 7401, Issue , 2009, Pages

  Müller, Bert ^a,b   Deyhle, Hans ^a,b   Fierz, Fabienne C ^a   Irsen, Stephan H ^c   Yoon, Jin Y ^a,b   Mushkolaj, Shpend ^a   Boss, Oliver ^a   Vorndran, Elke ^d   Gburek, Uwe ^d   Degistirici, Özer ^c,e   Thie, Michael ^c,f   Leukers, Barbara ^c,g   Beckmann, Felix ^h   Witte, Frank ⁱ  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^f UNIVERSITY OF WITTEN HERDECKE   (Germany)

^g Lohmann GmbH and Co KG   (Germany)

^h INSTITUTE OF MATERIALS RESEARCH   (Germany)

ⁱ HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

3D printing; Bone architecture; Cyto compatibility; Hydroxyapatite; Microstructure; Nanostructure; Synchrotron radiation; Tomography; Tri calcium phosphate

Indexed keywords

3D PRINTING; BASE MATERIAL; BIOLOGICAL CELLS; BONE ARCHITECTURE; CALCIUM PHOSPHATE SCAFFOLDS; CAPILLARY FORMATION; CELL INFILTRATION; CELL MIGRATION; CELL NUTRITION; COMPLEX ARCHITECTURES; CYTO-COMPATIBILITY; HIERARCHICAL STRUCTURES; HOLLOW SPHERE; LONG BONE; NANO-METER SCALE; NANO-POROUS; NANOPOROSITY; POROUS SCAFFOLD; TECHNICAL APPLICATIONS; TISSUE REGENERATION; TRI-CALCIUM PHOSPHATE; TRI-CALCIUM PHOSPHATES; WASTE REMOVAL;

APATITE; BIOMIMETICS; BLOOD VESSELS; BONE; CALCIUM; CALCIUM ALLOYS; CALCIUM PHOSPHATE; CELL MEMBRANES; CYTOLOGY; ELECTROMAGNETIC WAVES; HYDRAULIC STRUCTURES; HYDROXYAPATITE; MACROS; MICROSTRUCTURE; NANOSTRUCTURES; PRINTING; SYNCHROTRON RADIATION; SYNCHROTRONS; THREE DIMENSIONAL; TISSUE ENGINEERING; TOMOGRAPHY;

SCAFFOLDS;

EID: 70350150195     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.825487     Document Type: Conference Paper

References (23)

1. C. X. F. Lam, X. M. Mo, S. H. Teoh et al., "Scaffold development using 3D printing with a starch-based polymer," Mat. Sci. Eng. 20, 49-56 (2002).
2. R. Lowmunkong, T. Sohmura, J. Takahashi et al., "Transformation of 3DP gypsum model to HA by treating in ammonium phosphate solution," J. Biomed. Mater. Res. B Appl. Biomater. 80, 386-393 (2007).
3. R. A. Giordano, B. M. Wu, S. W. Borland et al., "Mechanical properties of dense polylactic acid structures fabricated by three dimensional printing," J. Biomater. Sci. Polym. Ed. 8, 63-75 (1996).
4. W. Huang, Q. Zheng, W. Sun et al., "Levofloxacin implants with predefined micro structure fabricated by three-dimensional printing technique," Int. J. Pharm. 339, 33-38 (2007).
5. U. Gbureck, T. Hölzel, C. Doillon et al., "Direct printing of bioceramic implants with spatially localised angiogenic factors," Adv. Mater. 19, 795-800 (2007).
6. A. Khalyfa, S. Vogt, J. Weisser et al., "Development of a new calcium phosphate powder-binder system for the 3D printing of patient specific implants," J. Mater. Sci. Mater. Med. 18, 909-916 (2007).
7. B. Leukers, H. Gulkan, S. H. Irsen et al., "Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing," J. Mater. Sci. Mater. Med. 16, 1121-1124 (2005).
8. R. Chumnanklang, T. Panyathanmaporn, K. Sitthiseripratip et al., "3D printing of hydroxyapatite: Effect of binder concentration inpre-coated particle on part strength," Mat. Sci. Eng. C27, 914-921 (2007).
9. H. Seitz, W. Rieder, S. Irsen et al., "Three-dimensional printing of porous ceramic scaffolds for bone tissue engineering," J. Biomed. Mater. Res. Part B: Appl. Biomater. 74, 782-788 (2005).
10. J. E. Barralet, K. J. Lilley, L. M. Grover et al., "Cements from nanocrystalline hydroxyapatite," J. Mater. Sci. Mater. Med. 15, 407-411 (2004).
11. J. E. Barralet, M. J. Tremayne, K. J. Lilley et al., "Chemical modification of calcium phosphate cements with hydroxy acids and their salts," Chem. Mater. 17, 1313-1319 (2005).
12. F. C. Fierz, F. Beckmann, M. Huser et al., "The morphology of anisotropic 3D-printed hydroxyapatite scaffolds," Biomaterials 29, 3799-3806 (2008).
13. S. H. Irsen, B. Leukers, C. Hockling et al., "Bioceramic granulates for use in 3D printing: Process engineering aspects," Materialwissenschaft und Werkstofftechnik 37, 533-537 (2006).
14. F. Beckmann, "Microtomography using synchrotron radiation as a user experiment at beamlines BW2 and BW5 of HASYLAB at DESY," Proc. SPIE 4503, 34-41.
15. B. Müller, P. Thurner, F. Beckmann et al., "Non-destructive three-dimensional evaluation of biocompatible materials by microtomography using synchrotron radiation," Proc. SPIE 4503, 178-188.
16. B. Müller, R. Bernhardt, T. Weitkamp et al., "Morphology of bony tissues and implants uncovered by high-resolution tomographic imaging," Int. J. Mat. Res. 98, 613-621 (2007).
17. A. C. Kak, and M. Slaney, [Principles of Computerized Tomographic Imaging] IEEE Press, New York (1988).
18. O. Degistirici, C. Jaquiery, B. Schoenebeck et al., "Defining Properties of neural Crest-Derived Progenitor Cells from the Apex of Human Developing Tooth," Tissue Engineering: Part A 14, 317-330 (2008).
19. B. K. Hoffmeister, S. R. Smith, S. M. Handley et al., "Anisotropy of Young's modulus of human tibial cortical bone," Med. Biol. Eng. Comput. 38, 333-338 (2000).
20. F. R. Rose, L. A. Cyster, D. M. Grant et al., "In vitro assessment of cell penetration into porous hydroxyapatite scaffolds with a central aligned channel," Biomaterials 25, 5507-5514 (2004).
21. U. Geburek, T. Holzel, U. Klammert et al., "Resorbable dicalcium phosphate bone substitutes made by 3D powder printing," Adv. Func. Mater. 17, 3940-3945 (2007).
22. U. Klammert, T. Reuther, C. Jahn et al., "Cytocompatibility of brushite and monetite cell culture scaffolds made by three-dimensional powder printing," Acta Biomaterialia 5, 727-734 (2009).
23. B. Leukers, H. Gulkan, S. Irsen et al., "Biocompatibility of ceramic scaffolds for bone replacement made by 3D printing," Materialwissenschaft und Werkstofftechnik 36, 781-787 (2005).