TIMP-3: A novel target for glucocorticoid signaling at the blood-brain barrier

Biochemical and Biophysical Research Communications

Volumn 390, Issue 2, 2009, Pages 182-186

  Hartmann, Christoph ^a   El Gindi, Jehad ^a   Lohmann, Christina ^a   Lischper, Mira ^a   Zeni, Patrick ^a   Galla, Hans Joachim ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Blood brain barrier; Extracellular matrix; Hydrocortisone; Tissue inhibitor of metalloproteinases

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE; MATRIX METALLOPROTEINASE; MIFEPRISTONE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APICAL MEMBRANE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PROTECTION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; ENDOTHELIUM; EXTRACELLULAR MATRIX; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SUPERNATANT; UPREGULATION;

ANIMALS; BLOOD-BRAIN BARRIER; ENDOTHELIUM, VASCULAR; GLUCOCORTICOIDS; HYDROCORTISONE; SIGNAL TRANSDUCTION; SWINE; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 70350128751     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.08.158     Document Type: Article

References (21)

1. Hawkins B.T., and Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57 (2005) 173-185
2. Haorah J., Ramirez S.H., Schall K., Smith D., Pandya R., and Persidsky Y. Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. J. Neurochem. 101 (2007) 566-576
3. Leppert D., Lindberg R.L., Kappos L., and Leib S.L. Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis. Brain Res. 36 (2001) 249-257
4. Sternlicht M.D., and Werb Z. How matrix metalloproteinases regulate cell behavior. Annu. Rev. Cell Dev. Biol. 17 (2001) 463-516
5. Lohmann C., Krischke M., Wegener J., and Galla H.J. Tyrosine phosphatase inhibition induces loss of blood-brain barrier integrity by matrix metalloproteinase-dependent and -independent pathways. Brain Res. 995 (2004) 184-196
6. Nagase H., Visse R., and Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc. Res. 69 (2006) 562-573
7. Yu W.H., Yu S., Meng Q., Brew K., and Woessner J. TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix. J. Biol. Chem. 275 (2000) 31226-31232
8. Fassina G., Ferrari N., Brigati C., Benelli R., Santi L., Noonan D.M., and Albini A. Tissue inhibitors of metalloproteases: regulation and biological activities. Clin. Exp. Metastasis 18 (2000) 111-120
9. Baker A.H., Edwards D.R., and Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J. Cell Sci. 115 (2002) 3719-3727
10. Amour A., Slocombe P.M., Webster A., Butler M., Knight C.G., Smith B.J., Stephens P.E., Shelley C., Hutton M., Knauper V., Docherty A.J., and Murphy G. TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3. FEBS Lett. 435 (1998) 39-44
11. Leco K.J., Waterhouse P., Sanchez O.H., Gowing K.L., Poole A.R., Wakeham A., Mak T.W., and Khokha R. Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). J. Clin. Invest. 108 (2001) 817-829
12. Harkness K.A., Adamson P., Sussman J.D., Davies-Jones G.A., Greenwood J., and Woodroofe M.N. Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium. Brain 123 Pt. 4 (2000) 698-709
13. Forster C., Kahles T., Kietz S., and Drenckhahn D. Dexamethasone induces the expression of metalloproteinase inhibitor TIMP-1 in the murine cerebral vascular endothelial cell line cEND. J. Physiol. 580 (2007) 937-949
14. Rosenberg G.A., Dencoff J.E., Correa Jr. N., Reiners M., and Ford C.C. Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis: relation to blood-brain barrier injury. Neurology 46 (1996) 1626-1632
15. Franke H., Galla H., and Beuckmann C.T. Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitro. Brain Res. Brain Res. Protoc. 5 (2000) 248-256
16. Zozulya A., Weidenfeller C., and Galla H.J. Pericyte-endothelial cell interaction increases MMP-9 secretion at the blood-brain barrier in vitro. Brain Res. 1189 (2008) 1-11
17. Hoheisel D., Nitz T., Franke H., Wegener J., Hakvoort A., Tilling T., and Galla H.J. Hydrocortisone reinforces the blood-brain properties in a serum free cell culture system. Biochem. Biophys. Res. Commun. 247 (1998) 312-315
18. Candelario-Jalil E., Yang Y., and Rosenberg G.A. Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience 1 (2008) 1
19. Bugno M., Witek B., Bereta J., Bereta M., Edwards D.R., and Kordula T. Reprogramming of TIMP-1 and TIMP-3 expression profiles in brain microvascular endothelial cells and astrocytes in response to proinflammatory cytokines. FEBS Lett. 448 (1999) 9-14
20. Zeni P., Doepker E., Schulze-Topphoff U., Huewel S., Tenenbaum T., and Galla H.J. MMPs contribute to TNF-alpha-induced alteration of the blood-cerebrospinal fluid barrier in vitro. Am. J. Physiol. Cell Physiol. 293 (2007) C855-C864
21. Rosenberg G.A. Matrix metalloproteinases in neuroinflammation. Glia 39 (2002) 279-291