Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro

Acta Pharmaceutica

Volumn 59, Issue 3, 2009, Pages 325-334

  Ray, Sarbani Dey ^a   Roy, Partha Praim ^b   Ray, Supratim ^a  

^a Dr B C Roy College of Pharmacy and Allied Health Sciences   (India)

^b JADAVPUR UNIVERSITY   (India)

Author keywords

Ascorbic acid; Immunostimulating drug; Lipid peroxidation; Malondialdehyde; Reduced glutathione; Sterodin

Indexed keywords

ASCORBIC ACID; ERGOCALCIFEROL; GLUTATHIONE; IMMUNOSTIMULATING AGENT; INDIAN INK; LIPID; MALONALDEHYDE; IMMUNOLOGICAL ADJUVANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GOAT; IMMUNE SYSTEM; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LD 50; LEUKOCYTE COUNT; LIPID PEROXIDATION; LIVER; MALE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PHAGOCYTOSIS; TOXICITY TESTING; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; LIPID METABOLISM; METABOLISM; NEUTROPHIL; PHYSIOLOGY; PILOT STUDY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; GLUTATHIONE; GOATS; LETHAL DOSE 50; LEUKOCYTE COUNT; LIPID METABOLISM; LIPID PEROXIDATION; LIPIDS; LIVER; MALE; MICE; NEUTROPHILS; PHAGOCYTOSIS; PILOT PROJECTS;

EID: 70350112124     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10007-009-0030-y     Document Type: Article

References (14)

1. B. Klausen, R. T. Evans, N. S. Ramamurthy, L. M. Golub, C. Sfintescu, J. Y. Lee, G. Bedi, J. J. Zambon and R. J. Genco, Periodontal bone level and proteinase activity in gnotobiotic rats immunized with Bacteroides gingivalis, Oral Microbiol. Immunol. 6 (1991) 193-201; DOI: 10.1111/ j.1399-302X.1991. tb00477.x.
2. B. Halliwell and J. M. C. Gutteridge, Free Radicals in Biology and Medicine, 2nd ed., Oxford University Press, Oxford 1989, pp. 195-205.
3. B. Halliwell, Drug antioxidant effects - A basis for drug selection, Drugs 42 (1991) 569-605; DOI: 10.2165/00003495-199142040-00003.
4. S. Ray, K. Roy and C. Sengupta, In vitro evaluation of protective effects of ascorbic acid and water extract of Spirulina platenesis (blue green algae) on 5-fluorouracil-induced lipid peroxidation, Acta Pol. Pharm. - Drug Res. 64 (2007) 335-344. (Pubitemid 351360412)
5. T. P. Hilditch and P. N. Williams, The Chemical Constituents of Fats, Chapman & Hall, London 1964, pp. 100-133.
6. D. J. Finney, Probit Analysis: A Statistical Treatment of Sigmoid Response Curve, Cambridge University Press, London 1971.
7. Unated States Pharmacopoeia, 28/National Formulary 23, USP Convention, Rockville 2005, p. 2272.
8. P. C. Wilkinson, Immunology in Medicine, Academic Press, New York, 1974, pp. 234-252.
9. R. H. Gokani, S. K. Lahiri, D. D. Santani and M. B. Shah, Evaluation of immunomodulatory activity of Clerodendrum phlomidis and Premna integrifolia, Int. J. Pharmacology 3 (2007) 352-356; DOI: 10.3923/ijp.2007.352.356.
10. H. Ohkawa, N. Ohishi and K. Yagi, Assay of lipid peroxidation in animal tissue by thiobarbituric acid reaction, Anal. Biochem. 95 (1979) 351-358; DOI: 10.1016/0003-2697(79)90738-3. (Pubitemid 9194347)
11. G. L. Ellman, Tissue sulfhydryl groups, Arch. Biochem. Biophys. 82 (1959) 70-77; DOI: 10.1016/ 0003-9861(59)90090-90096
12. S. Bolton, Statistics, in Remington: The Science and Practice of Pharmacy (Ed. A. R. Gennaro), 20th ed., Volume I, Lippincott Williams & Wilkins, Philadelphia 2001, pp. 124-158.
13. B. Halliwell and J. M. C. Gutteridge, Role of free radicals and catalytic metal ion in human disease - an overview, Methods Enzymol. 186 (1990) 1-85; DOI: 10.1016/0076-6879(90)86093-B. (Pubitemid 20279941)
14. V. Herbert, Pro-oxidant effects of antioxidant vitamins, J. Nutr. 126 (1996) 1197-1200.