Compressed matrix dual-component vaginal drug delivery system containing metoclopramide hydrochloride

Acta Pharmaceutica

Volumn 59, Issue 3, 2009, Pages 273-288

  Patel, Geeta ^a   Patel, Madhabhai ^b  

^a GANPAT UNIVERSITY   (India)

^b Kalol Institute of Technology and Research   (India)

Author keywords

Dual component system; Factorial design; Metoclopramide; Mucoadhesion; Quick slow release; Vaginal drug delivery

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; METOCLOPRAMIDE; POLYMER;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; FOURIER TRANSFORMATION; HYDROPHILICITY; INFRARED SPECTROSCOPY; NAUSEA; SUSTAINED RELEASE FORMULATION; TABLET FORMULATION; VAGINA; VOMITING;

EID: 70350089865     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10007-009-0029-4     Document Type: Article

References (20)

1. K. Vermani and S. Garg, The scope and potential of vaginal drug delivery, PSTT, 3 (2000) 359- 364; DOI: S1461-5347(00)00296-300
2. P. Colombo, U. Conte and A. Gazzaniga, Drug release modulation by physical restrictions of matrix swelling, Int. J. Pharm. 63 (1990) 43-48; DOI: 10.1016/0378-5173(90)90099-P. (Pubitemid 20305592)
3. Y. Qiu, N. Chidambaram and K. Flood, Design and evaluation of layered diffusional matrices for zero-order sustained release, J. Control. Rel. 51 (1998) 123-130; DOI: PII S0168-3659(97)00119-3. (Pubitemid 28252863)
4. N. Chidambaram, W. Porter, K. Flood and Y. Qui, Formulation and characterization of new layered diffusional matrices for zero-order sustained release, J. Control. Rel. 52 (1998) 149-158; DOI: 10.1016/S0168-3659(97)00207-1. (Pubitemid 28123182)
5. U. Conte and L. Maggi, A flexible technology for the linear, pulsative and delayed release drugs, allowing for easy accommodation of difficult in vitro targets, J. Control. Rel. 64 (2000) 263-268; DOI: 10.1016/S0168-3659(99)00147- 9. (Pubitemid 30035324)
6. N. M. Zakia, G. A. Awada, N. D. Mortadaa, S. Seham and A. E. Hady, Enhanced bioavailability of metoclopramide HCl by intranasal administration of a mucoadhesive in situ gel with modulated rheological and mucociliary transport properties, Eur. J. Pharm. Sci. 3 (2007) 296-307; DOI: 10.1016/j.ejps.2007.08. 006. (Pubitemid 350064481)
7. S. Lybak, E. Kjellen, P. Nilsson, A. Tomaszewicz, J. Wennerberg and R. W. Pero, Normal tissue reactions in mice after combined treatment with metoclopramide and ionizing radiation, Acta Oncol. 31 (1992) 469-474.
8. J. Wennerberg, E. Kjellen, S. Lybak, R. Rydell and R. Pero, Biochemical modulation of chemotherapy and radiotherapy in head and neck cancer, Anticancer Res. 13 (1993) 2501-2506.
9. A. Olsson, Y. Sheng, E. Kjellen and R. W. Pero, In vivo tumor measurement of DNA damage, DNA repair and NAD pools as indicators of radiosensitization by metoclopramide, Carcinogenesis 16 (1995) 1029-1035.
10. R. A. Harrington, C. W. Hamilton, R. N. Brogden, J. A. Linkewich, J. A. Romankiewicz and R. C. Heel, Metoclopramide: an updated review of its pharmacological properties and clinical use, Drugs 25 (1983) 451-494.
11. D. M. Brahmankar and S. B. Jaiswal, Application of Pharmacokinetic Principles - Biopharmaceutics and Pharmacokinetics, 1st ed., Vallaph Prakashan, Delhi 1998, p. 311.
12. H. C. Ansel, L. V. Allen and N. G. Popovich, Capsules and Tablets, in Pharmaceutical Dosage Forms and Drug Delivery Systems, 7th ed., LippincottWilliams &Wilkins, Philadelphia 2002, pp. 204-209.
13. C. N. Patra, A. B. Kumar, H. K. Pandit, S. P. Singh and M. V. Devi, Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride, Acta Pharm. 57 (2007) 479-489; DOI: 10.2478/v10007-007-0038-0.
14. United States Pharmacopoeia 28, National Formulary 23, Asian Edition, USP Convention, Rockville (MD) 2005, p. 1277.
15. Guidance for Industry, SUPAC-MR: Modified Release Solid Oral Dosage Forms. Scale-Up and Postapproval Changes: Chemistry, Manufacturing, and Controls; In Vitro Dissolution Testing and In Vivo Bioequivalence Documentation, U. S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER) September 1997, CMC 8, Rockville (MD) 1997, p. 32.
16. P. Costa, J. Manuel and S. Labao, Modeling and comparison of dissolution profiles, Eur. J. Pharm. Sci. 13 (2001) 123-133; DOI: 10.1016/S0928-0987(01) 00095-1. (Pubitemid 32288781)
17. R. W. Korsmeyer, R. Gurny, E. Docler, P. Buri and N. A. Peppas, Mechanism of solute release from porous hydrophilic polymers, Int. J. Pharm. 15 (1983) 25-35; DOI: 10.1016/0378-5173(83) 90064-9.
18. N. A. Peppas, Analysis of Fickian and non Fickian drug release from polymers, Pharm. Acta Helv. 60 (1985) 110-111.
19. N. Adel, N. Fatma, A. Ismail, N. A. Boraie and L. M. Mortada, Mucoadhesive delivery systems. I. Evaluation of mucoadhesive polymers for buccal tablet formulation, Drug. Dev. Ind. Pharm. 30 (2004) 985-993; DOI: 10.1081/DDC-200037245. (Pubitemid 39453050)
20. J. Moore and H. Flanner, Mathematical comparison of dissolution profiles, Pharm. Tech. 20 (1996) 64-74.