Small interfering RNAs (siRNAs) targeting TGF-Β1 mRNA suppress asbestos-induced expression of TGF-Β1 and CTGF in fibroblasts

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 28, Issue 2, 2009, Pages 109-119

  Lai, Tai Cheng ^a,b   Pociask, Derek A ^c   Ferris, Marybeth ^d   Nguyen, Hong T ^d   Miller Iii, Charles A ^a   Brody, Arnold ^e   Sullivan, Deborah ^d  

^a TULANE UNIVERSITY   (United States)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^e NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Asbestos; Connective tissue growth factor; Interstitial lung disease; RNA interference; Small interfering RNA; Transforming growth factor 1

Indexed keywords

CHRYSOTILE; CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; DRUG EFFICACY; FIBROBLAST; GENETIC TRANSFECTION; INTERSTITIAL LUNG DISEASE; LUNG FIBROSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING; UPREGULATION;

MURINAE;

EID: 70350089863     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i2.30     Document Type: Article

References (61)

1. Lasky J, Brody A. Interstitial fibrosis and growth factors. Env Health Perspect. 2000;108(Suppl 4):751-762
2. Begin R, Masse S, Sebastien P, Bosse J, Rola-Pleszczynski M, Boctor M, Cote Y, Fabi D, Dalle D. Asbestos exposure and retention as determinants of airway disease and asbestos alveolitis. Am Rev Respir Dis. 1986;134(6):1176-1181
3. Vitums VC, Edwards MJ, Niles NR, Borman JO, Lowry RD. Pulmonary fibrosis from amorphous silica dust, a product of silica vapor. Arch Environ Health. 1977;32(2):62-68
4. Thrall RS, McCormick JR, Jack RM, McReynolds RA, Ward PA. Bleomycin-induced pulmonary fi- brosis in the rat: inhibition by indomethacin. Am J Pathol. 1979;95(1):117-130
5. Selman M. From anti-inflammatory drugs through antifibrotic agents to lung transplantation: a long road of research, clinical attempts, and failures in the treatment of idiopathic pulmonary fibrosis. Chest. 2002;122(3):759-761
6. Sime PJ, O'Reilly KM. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clin Immunol. 2001;99(3):308-319
7. Walter N, Collard HR, King TE Jr. Current perspectives on the treatment of idiopathic pulmonary fi- brosis. Proc Am Thorac Soc. 2006;3(4):330-338
8. Moses HL, Coffey RJ Jr, Leof EB, Lyons RM, Keski- Oja J. Transforming growth factor beta regulation of cell proliferation. J Cell Physiol Suppl. 1987;Suppl 5:1-7.
9. Jetten AM, Shirley JE, Stoner G. Regulation of proliferation and differentiation of respiratory tract epithelial cells by TGF beta. Exp Cell Res. 1986;167(2):539-549
10. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1. Proc Natl Acad Sci U S A. 1992;89(12):5408-5412
11. Alexandrow MG, Moses HL. Transforming growth factor beta and cell cycle regulation. Cancer Res. 1995;55(7):1452-1457
12. Akhurst RJ, FitzPatrick DR, Gatherer D, Lehnert SA, Millan FA. Transforming growth factor betas in mammalian embryogenesis. Prog Growth Factor Res. 1990;2(3):153-168
13. Engelmann GL, Boehm KD, Birchenall-Roberts MC, Ruscetti FW. Transforming growth factor-beta 1 in heart development. Mech Dev. 1992;38(2):85-97.
14. Licona-Limon P, Soldevila G. The role of TGF-beta superfamily during T cell development: new insights. Immunol Lett. 2007;109(1):1-12.
15. Montesano R, Orci L. Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci U S A. 1988;85(13):4894-4897
16. Faler BJ, Macsata RA, Plummer D, Mishra L, Sidawy AN. Transforming growth factor-beta and wound healing. Perspect Vasc Surg Endovasc Ther. 2006;18(1):55-62.
17. Grande JP. Role of transforming growth factor-beta in tissue injury and repair. Proc Soc Exp Biol Med. 1997;214(1):27-40.
18. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH, Fauci AS. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A. 1986;83(12):4167-4171
19. Fajardo LF, Prionas SD, Kwan HH, Kowalski J, Allison AC. Transforming growth factor beta1 induces angiogenesis in vivo with a threshold pattern. Lab Invest. 1996;74(3):600-608
20. Pardali K, Moustakas A. Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta. 2007;1775(1):21-62.
21. Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, Allen R, Sidman C, Proetzel G, Calvin D, Annunziata N, Doetschman T. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature. 1992;359(6397):693-699
22. Yoshida M, Hayashi S. [Role of TGF-beta and PDGF on the pathogenesis of pulmonary fibrosis- -analysis by in vivo gene transfer]. Nippon Rinsho. 1996;54(2):418-422
23. Brody AR, Warshamana GS, Jing Y, Pociask DA. Expression of transforming growth factor-beta induces fibroproliferative pulmonary disease in fibrosis-resistant mice. Chest. 2001;120(1 Suppl):48S-9S.
24. Liu JY, Sime PJ, Wu T, Warshamana GS, Pociask D, Tsai SY, Brody AR. Transforming growth factor- beta(1) overexpression in tumor necrosis factor- alpha receptor knockout mice induces fibroproliferative lung disease. Am J Respir Cell Mol Biol. 2001;25(1):3-7.
25. Broekelmann TJ, Limper AH, Colby TV, McDonald JA. Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in hu- man pulmonary fibrosis. Proc Natl Acad Sci U S A. 1991;88(15):6642-6646
26. Bergeron A, Soler P, Kambouchner M, Loiseau P, Milleron B, Valeyre D, Hance AJ, Tazi A. Cytokine profiles in idiopathic pulmonary fibrosis suggest an important role for TGF-beta and IL-10. Eur Respir J. 2003;22(1):69-76.
27. Brigstock DR. The connective tissue growth factor/ cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev. 1999;20(2):189-206.
28. Allen JT, Spiteri MA. Growth factors in idiopathic pulmonary fibrosis: relative roles. Respir Res. 2002;3(1):13-21.
29. Blom IE, Goldschmeding R, Leask A. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol. 2002;21(6): 473-482
30. Voinnet O. Induction and suppression of RNA silencing: insights from viral infections. Nat Rev Genet. 2005;6(3):206-220
31. Volpe TA, Kidner C, Hall IM, Teng G, Grewal SI, Martienssen RA. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science. 2002;297(5588):1833-1837
32. Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001;106(1):23-34.
33. Liu G, Wong-Staal F, Li QX. Development of new RNAi therapeutics. Histol Histopathol. 2007;22(2):211-217
34. Buder-Hoffmann S, Palmer C, Vacek P, Taatjes D, Mossman B. Different accumulation of activated extracellular signal-regulated kinases (ERK 1/2) and role in cell-cycle alterations by epidermal growth factor, hydrogen peroxide, or asbestos in pulmonary epithelial cells. Am J Respir Cell Mol Biol. 2001;24(4):405-413
35. Shukla A, Barrett TF, Nakayama KI, Nakayama K, Mossman BT, Lounsbury KM. Transcriptional upregulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. Faseb J. 2006;20(7):997-999
36. Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol. 2003;21(6):635-637
37. Couzin J. Molecular biology. RNAi shows cracks in its armor. Science. 2004;306(5699):1124-1125
38. Jackson AL, Linsley PS. Noise amidst the silence: off-target effects of siRNAs? Trends Genet. 2004;20(11):521-524
39. Scacheri PC, Rozenblatt-Rosen O, Caplen NJ, Wolfsberg TG, Umayam L, Lee JC, Hughes CM, Shanmugam KS, Bhattacharjee A, Meyerson M, Collins FS. Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A. 2004;101(7):1892-1897
40. Bridge AJ, Pebernard S, Ducraux A, Nicoulaz AL, Iggo R. Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet. 2003;34(3):263-264
41. Doench JG, Petersen CP, Sharp PA. siRNAs can function as miRNAs. Genes Dev. 2003;17(4):438-442
42. Khalil N, Greenberg AH. The role of TGF-beta in pulmonary fibrosis. Ciba Found Symp. 1991;157:194- 207; discussion 207-211
43. Liu J-Y, Brody AR. Increased TGF-?1 in the lungs of asbestos-exposed rats and mice: reduced expression in TNF-? receptor knockout mice. J Environ Pathol Toxicol Oncol. .2001;20(2):77-87.
44. Yin Q, Brody AR, Sullivan DE. Laser capture microdissection reveals dose-response of gene expression in situ consequent to asbestos exposure. Int J Exp Pathol. 2007;88(6):415-425
45. Brody AR, Liu JY, Brass D, Corti M. Analyzing the genes and peptide growth factors expressed in lung cells in vivo consequent to asbestos exposure and in vitro. Environ Health Perspect. 1997;105 Suppl 5:1165-1171
46. Selman M, Thannickal VJ, Pardo A, Zisman DA, Martinez FJ, Lynch JP, 3rd. Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches. Drugs. 2004;64(4):405-430
47. Phan SH. Fibroblast phenotypes in pulmonary fi- brosis. Am J Respir Cell Mol Biol. 2003;29(3 Suppl): S87-92.
48. Sullivan DE, Ferris M, Pociask D, Brody AR. Tumor necrosis factor-alpha induces transforming growth factor-beta1 expression in lung fibroblasts through the extracellular signal-regulated kinase pathway. Am J Respir Cell Mol Biol. 2005;32(4):342-349
49. Sullivan DE, Ferris M, Pociask D, Brody AR. The latent form of TGFbeta(1) is induced by TNFalpha through an ERK specific pathway and is activated by asbestos-derived reactive oxygen species in vitro and in vivo. J Immunotoxicol. 2008;5(2):145-149
50. Sullivan DE, Ferris M, Nguyen H, Abboud E, Brody AR. TNF-alpha induces TGF-beta(1) expression in lung fibroblasts at the transcriptional level via AP-1 activation. J Cell Mol Med. 2009;Jan 14 [Epub ahead of print].[[AU: PLS UPDATE IF POSSIBLE.]]
51. Warshamana GS, Corti M, Brody AR. TNF-alpha, PDGF, and TGF-beta(1) expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells: tnf-alpha induces TGF-beta(1). Exp Mol Pathol. 2001;71(1):13-33.
52. Pociask DA, Sime PJ, Brody AR. Asbestos-derived reactive oxygen species activate TGF-beta1. Lab Invest. 2004;84(8):1013-1023
53. Lasky JA, Ortiz LA, Tonthat B, Hoyle GW, Corti M, Athas G, Lungarella G, Brody A, Friedman M. Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am J Physiol. 1998;275(2 Pt 1):L365-71.
54. Pan LH, Yamauchi K, Uzuki M, Nakanishi T, Takigawa M, Inoue H, Sawai T. Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF. Eur Respir J. 2001;17(6):1220-1227
55. Ingman WV, Robertson SA. Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Endocrinology. 2007;148(8): 4032-4043
56. Ingman WV, Robker RL, Woittiez K, Robertson SA. Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest. Endocrinology. 2006;147(2):835-845
57. Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, Roberts AB, Sporn MB, Ward JM, Karlsson S. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A. 1993;90(2):770-774
58. Dykxhoorn DM, Lieberman J. Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. Annu Rev Biomed Eng. 2006;8:377-402.
59. Howell DC, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC. Absence of proteinase- activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fi- brosis. Am J Pathol. 2005;166(5):1353-1365
60. Simpson DA, Feeney S, Boyle C, Stitt AW. Retinal VEGF mRNA measured by SYBR green I fluorescence: A versatile approach to quantitative PCR. Mol Vis. 2000;6:178-183
61. Overbergh L, Valckx D, Waer M, Mathieu C. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine. 1999;11(4):305-312