Ceragenins: A class of antiviral compounds to treat orthopox infections

Journal of Investigative Dermatology

Volumn 129, Issue 11, 2009, Pages 2668-2675

  Howell, Michael D ^a,b   Streib, Joanne E ^a,b   Kim, Byung Eui ^a,b,c   Lesley, Leighann J ^a,b   Dunlap, Annegret P ^a,b   Geng, Dianliang ^d   Feng, Yanshu ^d   Savage, Paul B ^d   Leung, Donald Y M ^a,b  

^a DEPARTMENT OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Inje University   (South Korea)

^d Brigham Young University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; CERAGENIN; CERAGENIN 13; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISSEMINATED SKIN INFECTION; DRUG EFFICACY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MOUSE; NONHUMAN; ORTHOPOXVIRUS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN DEFECT; SKIN INFECTION; SKIN PENETRATION; VACCINIA; VACCINIA VIRUS; VIRUS REPLICATION;

EID: 70350074755     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.120     Document Type: Article

References (31)

1. Amegadzie BY, Ahn BY, Moss B (1991) Identification, sequence, and expression of the gene encoding a Mr 35,000 subunit of the vaccinia virus DNA-dependent RNA polymerase. J Biol Chem 266:13712-13718
2. Barrandon Y, Green H (1985) Cell size as a determinant of the clone-forming ability of human keratinocytes. Proc Natl Acad Sci USA 82:5390-5394
3. Bicknell WJ (2002) The case for voluntary smallpox vaccination. N Engl J Med 346:1323-1325
4. Burgel PR, Nadel JA (2008) Epidermal growth factor receptor-mediated innate immune responses and their role in airway diseases. Eur Respir J 32:1068-1081
5. Burgess AW (2008) EGFR family: sturcture physiology signaling and therapeutic targets. Growth Factors 26:263-274
6. Cono J, Casey CG, Bell DM (2003) Smallpox vaccination and adverse reactions. Guidance for clinicians. MMWR Recomm Rep 52:1-28
7. Ding B, Guan Q, Walsh JP, Boswell JS, Winter TW, Winter ES et al. (2002) Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics. J Med Chem 45:663-669
8. Ding B, Taotofa U, Orsak T, Chadwell M, Savage PB (2004a) Synthesis and characterization of peptide-cationic steroid antibiotic conjugates. Org Lett 6:3433-3436
9. Ding B, Yin N, Liu Y, Cardenas-Garcia J, Evanson R, Orsak T et al. (2004b) Origins of cell selectivity of cationic steroid antibiotics. J Am Chem Soc 126:13642-13648
10. Gabel CA (2007) P2 purinergic receptor modulation of cytokine production. Purinergic Signal 3:27-38
11. Heuser J (2005) Deep-etch EM reveals that the early poxvirus envelope is a single membrane bilayer stabilized by a geodetic ''Honeycomb'' surface coat. J Cell Biol 169:269-283
12. Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE et al. (2006) Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity 24:341-348
13. Howell MD, Jones JF, Kisich KO, Streib JE, Gallo RL, Leung DY (2004) Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum. J Immunol 172:1763-1767
14. Howell MD, Streib JE, Leung DY (2007) Antiviral activity of human beta-defensin 3 against vaccinia virus. J Allergy Clin Immunol 119:1022-1025
15. Kim BE, Leung DY, Boguniewicz M, Howell MD (2008) Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin Immunol 126:332-337
16. Kurth A, Wibbelt G, Gerber HP, Petschaelis A, Pauli G, Nitsche A (2008) Rat-to-elephant-to-human transmission of cowpox virus. Emerg Infect Dis 14:670-671
17. Li SM, Zhang ZT, Chan S, McLenan O, Dixon C, Taneja S et al. (1999) Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder. J Urol 162:931-935
18. Li YS, Wu P, Zhou XY, Chen JG, Cai L, Wang F et al. (2008) Formyl-peptide receptor like 1: a potent mediator of the Ca2+ release-activated Ca2+ current /CRAC. Arch Biochem Biophys 478:110-118
19. Marennikova SS, Condit RC, Moyer RW (2005) Orthopoxviruses Pathogenic for Humans. Springer Science and Business Media, Inc: New York, NY, 19-87
20. Neyts J, Leyssen P, Verbeken E, De Clercq E (2004) Efficacy of cidofovir in a murine model of disseminated progressive vaccinia. Antimicrob Agents Chemother 48:2267-2273
21. Nomura I, Goleva E, Howell MD, Hamid QA, Ong PY, Hall CF et al. (2003) Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 171:3262-3269
22. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T et al. (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151-1160
23. World Health Organization (1980) Declaration of global eradication of smallpox. Wkly Epidemiol Rec 55:148
24. Rehman A, Li C, Budge LP, Street SE, Savage PB (1999) Preparation of amino acid-appended cholic acid derivatives as sensitizers of gram-negative bacteria. Tetrahedron Lett 40:1865-1868
25. Reynolds MG, Davidson WB, Curns AT, Conover CS, Huhn G, Davis JP et al. (2007) Spectrum of infection and risk factors for human monkeypox, United States, 2003. Emerg Infect Dis 13:1332-1339
26. Rodriguez D, Risco C, Rodriguez JR, Carrascosa JL, Esteban M (1996) Inducible expression of the vaccinia virus A17L gene provides a synchronized system to monitor sorting of viral proteins during morphogenesis. J Virol 70:7641-7653
27. Savage PB, Li C, Taotafa U, Ding B, Guan Q (2002) Antibacterial properties of cationic steroid antibiotics. FEMS Microbiol Lett 217:1-7
28. Smee DF, Bailey KW, Wong MH, Wandersee MK, Sidwell RW (2004) Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice. J Infect Dis 190:1132-1139
29. Tukey J (1977) Exploratory Data Analysis. Reading, NY: Addison Wesley
30. Vora S, Damon I, Fulginiti V, Weber SG, Kahana M, Stein SL et al. (2008) Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clin Infect Dis 46:1555-1561
31. Weber G, Farris FJ (1979) Synthesis and spectral properties of a hydrophobic fluorescent probe: 6-propionyl-2-(dimethylamino)naphthalene. Biochemistry 18:3075-3078