Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy

International Journal of Radiation Biology

Volumn 85, Issue 10, 2009, Pages 860-871

  Van Lent, Peter L E M ^a   Krijger, Gerard C ^b   Hofkens, Wouter ^a   Nievaart, Victor A ^c   Sloetjes, Annet W ^a   Moss, Ray L ^c   Koning, Gerben A ^b   Van Den Berg, Wim B ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Arthritis; BNCS; Joint inflammation; Liposomes; Macrophages; Synovial lining

Indexed keywords

BORON 10; DISODIUM DODECAHYDRODODECABORATE B 10; LIPOSOME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BORON NEUTRON CAPTURE SYNOVECTOMY; CARTILAGE DEGENERATION; CELL DEATH; CONTROLLED STUDY; DISEASE SEVERITY; DOSIMETRY; DRUG FORMULATION; DRUG TISSUE LEVEL; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; KNEE ARTHRITIS; MACROPHAGE; MOUSE; NEUTRON CAPTURE THERAPY; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; SYNOVECTOMY; SYNOVIUM;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BORON; BORON NEUTRON CAPTURE THERAPY; CELL DEATH; INJECTIONS, INTRA-ARTICULAR; ISOTOPES; JOINTS; LIPOSOMES; MACROPHAGES; MICE; MICE, INBRED C57BL; RADIOTHERAPY DOSAGE; SYNOVIAL MEMBRANE;

MURINAE; MUS;

EID: 70350049100     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553000903072454     Document Type: Article

References (57)

1. Barrera P, Blom A, van Lent PL, van Bloois L, Beijnen JH, van Rooijen N, de Waal Malefijt MC, van de Putte LB, Storm G, van den Berg WB. 2000. Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis. Arthritis and Rheumatism 43(9):1951-1959.
2. Briesmeister JF. 2000. MCNP - a general Monte Carlo N-particle transport code. Version 4C. LA-13709-M.
3. Chandra S, Lorey DR II. 2007. SIMS ion microscopy imaging of boronophenylalanine (BPA) and 13C15N-labeled phenylalanine in human glioblastoma cells: Relevance of subcellular scale observations to BPA-mediated boron neutron capture therapy of cancer. International Journal of Mass Spectrometry 260(2-3):90-101.
4. Chang CH, Liu YH, Chen AY, Jiang SH, Hsueh Liu YW, Liu HM. 2006. A study of neutron fluence rates of the BNCT beam at THOR using foil activation. 12th International Congress on Neutron Capture Therapy, Oct 9-13, Takamatsu, Japan.
5. de la Chapelle A, Rekonen A, Oka M, Ruotsi A. 1972. Chromosome damage after intra-articular injections of radioactive yttrium. Effect of immobilization on the biological dose. Annals of Rheumatic Diseases 31(6):508-512.
6. Chrapko B, Zwolak R, Nocun A, Golebiewska R, Majdan M. 2007. Radiation synovectomy with 90Y colloid in the therapy of recurrent knee joint effusions in patients with inflammatory joint diseases. Rheumatology International 27(8):729-734.
7. Clunie G, Ell PJ. 1995. A survey of radiation synovectomy in Europe, 1991-1993. European Journal of Nuclear Medicine 22(9):970-976.
8. Coderre JA, Morris GM. 1999. The radiation biology of boron neutron capture therapy. Radiation Research 151(1):1-18.
9. Coderre JA, Turcotte JC, Riley KJ, Binns PJ, Harling OK, Kiger III WS. 2003. Boron Neutron Capture Therapy: Cellular targeting of high linear energy transfer radiation. Technology in Cancer Research and Treatment 2(5):355-375.
10. Du H, Chandaroy P, Hui SW. 1997. Grafted poly-(ethylene glycol) on lipid surfaces inhibits protein adsorption and cell adhesion. Biochimica et Biophysica Acta. 1326(2):236-248.
11. Firestein GS. 2005. Immunologic mechanisms in the pathogenesis of rheumatoid arthritis. Journal of Clinical Rheumatology 11(3 Suppl).:S39-44.
12. Gumpel JM, Williams ED, Glass HI. 1973. Use of yttrium 90 in persistent synovitis of the knee. I. Retention in the knee and spread in the body after injection. Annals of Rheumatic Diseases 32(3):223-227.
13. Hall EJ, Giaccia AJ. 2006. Radiobiology for the radiologist. 6th ed. Philadelphia, PA: Lippincott, Williams and Wilkins.
14. Hardaker WT, Whipple TL, Bassett FH J. 1980. Diagnosis and treatment of the plica syndrome of the knee. Bone and Joint Surgery America 62(2):221-225.
15. Hawthorne MF. 1998. New horizons for therapy based on the boron neutron capture reaction. Molecular Medicine Today 4(4):174-181.
16. Hawthorne MF, Lee MW. 2003. A critical assessment of boron target compounds for boron neutron capture therapy. Journal of Neurooncololgy 62(1-2):33-45.
17. HawthorneMF, Shelly K. 1997. Liposomes as drug delivery vehicles for boron agents. Journal of Neurooncology 33(1-2):53-58.
18. International Atomic Energy Agency (IAEA). 1970. Neutron Fluence Measurements. Reports Series No-107. STI/DOC/10/107.
19. International Atomic Energy Agency (IAEA). 2001. Current status of neutron capture therapy. IAEA-TECDOC-1223, Vienna.
20. Jahangier ZN, Jacobs KM, Bijlsma JW, Lafeber FP. 2006. Radiation synovectomy with yttrium-90 for persisting arthritis has direct harmful effects on human cartilage that cannot be prevented by co-administration of glucocorticoids: An in vitro study. Annals of Rheumatic Diseases 65(10):1384-1389.
21. Jahangier ZN, van der Zant FM, Jacobs JW, Riedstra HG, Gommans GM, Verzijlbergen JF, Bijlsma JW, van Isselt JW. 2007. The intra-articular distribution of 90yttrium does not influence the clinical outcome of radiation synovectomy of the knee. Annals of Rheumatic Diseases 66(8):1110-1112.
22. Koning GA, Fretz MM, Woroniecka U, Storm G, Krijger GC. 2004. Targeting liposomes to tumor endothelial cells for neutron capture therapy. Applied Radiation and Isotopes 61 (5):963-967.
23. Koning GA, Krijger GC. 2007. Multimodal lipid-based nanocarriers for image-guided drug delivery. Current Medicinal Chemistry - Anticancer Agents 7(3):425-440.
24. Koning GA, Schiffelers RM, Wauben MH, Kok RJ, Mastrobattista E, Molema G, ten Hagen TL, Storm G. 2006. Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis. Arthritis and Rheumatism 54(4):1198-1208.
25. Kresnik E, Mikosch P, Gallowitsch HJ, Jesenko R, Just H, Kogler D, Gasser J, Heinisch M, Unterweger O, Kumnig G, Gomez I, Lind P. 2002. Clinical outcome of radiosynoviorthesis: A meta-analysis including 2190 treated joints. Nuclear Medicine Communications 23(7):683-688.
26. Krijger GC, Fretz MM, Woroniecka UD, Steinebach OM, Jiskoot W, Storm G, Koning GA. 2005. Tumor cell and tumor vasculature targeted liposomes for neutron capture therapy. Radiochimica Acta 93 (9-10):589-593.
27. Lens JW, van den Berg WB, van de Putte LB. 1984. Quantitation of arthritis by 99mTc-uptake measurements in the mouse knee-joint: Correlation with histological joint inflammation scores. Agents Actions 14(5-6):723-728.
28. Luo Y, Zhou H, Krueger J, Kaplan C, Lee SH, Dolman C, Markowitz D, Wu W, Liu C, Reisfeld RA, Xiang R. 2006. Targeting tumor-associated macrophages as a novel strategy against breast cancer. The Journal of Clinical Investigation 116(8):2132-2141.
29. Maroudas A. 1976. Transport of solutes through cartilage: Permeability to large molecules. Journal of Anatomy 122 (Pt 2):335-347.
30. Metselaar JM, van den Berg WB, Holthuysen AE, Wauben MH, Storm G, van Lent PL. 2004. Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis. Annals of Rheumatic Diseases 63(4):348-353.
31. Moghimi SM, Szebeni J. 2003. Stealth liposomes and long circulating nanoparticles: Critical issues in pharmacokinetics, opsonization and protein-binding properties. Progress in Lipid Research 42(6):463-478.
32. Morris GM, Coderre JA, Hopewell JW, Micca PL, Nawrocky MM, Liu HB, Bywaters A. 1994b. Response of the central nervous system to boron neutron capture irradiation: Evaluation using a rat spinal cord model. Radiotherapy and Oncology 32(3):249-255.
33. Morris GM, Coderre JA, Hopewell JW, Micca PL, Rezvani M. 1994a. Response of rat skin to boron neutron capture therapy with p-boronophenylalanine or borocaptate sodium. Radiotherapy and Oncology 32(2):144-153.
34. Morris GM, Coderre JA, Micca PL, Fisher CD, Capala J, Hopewell JW. 1997. Central nervous system tolerance to boron neutron capture therapy with p-boronophenylalanine. British Journal of Cancer 76(12):1623-1629.
35. Moss RL. 2005. The HFR: A key research reactor for Europe. International Journal for Nuclear Power (Atomwirtschaft) 113-116.
36. Mulherin D, Fitzgerald O, Bresnihan B. 1996. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis and Rheumatism 39(1):115-124.
37. Nievaart VA, Moss RL, Kloosterman JL, van der Hagen TH, van Dam H, Wittig A, Malago M, Sauerwein W. 2006. Design of a rotating facility for extracorporal treatment of an explanted liver with disseminated metastases by boron neutron capture therapy with an epithermal neutron beam. Radiation Research 166(1 Pt 1):81-88.
38. Okada Y, Nakanishi I, Kajikawa K. 1984. Repair of the mouse synovial membrane after chemical synovectomy with osmium tetroxide. Acta Pathology Japan 34(4):705-714.
39. Rassow J, Sauerwein W, Wittig A, Bourhis-Martin E, Hideghéty K, Moss R. 2004. Advantage and limitations of weighting factors and weighted dose quantities and their units in boron neutron capture therapy. Medical Physics 31:1128-1134.
40. Robinson-Smith TM, Isaacsohn I, Mercer CA, Zhou M, Van Rooijen N, Husseinzadeh N, McFarland-Mancini MM, Drew AF. 2007 Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice. Cancer Research 67(12):5708-5716.
41. Shortkroff S, Binello E, Zhu X, Gierga D, Thornhill TS, Shefer RE, Jones AG, Yanch JC. 2004. Dose response of the AIA rabbit stifle joint to boron neutron capture synovectomy. Nuclear Medicine and Biology 31(5):663-670.
42. Soden M, Rooney M, Whelan A, Feighery C, Bresnihan B. 1991. Immunohistological analysis of the synovial membrane: Search for predictors of the clinical course in rheumatoid arthritis. Annals of Rheumatic Diseases 50(10):673-676.
43. Smith JB, Haynes MK. 2002. Rheumatoid arthritis - a molecular understanding. Annals of Internal Medicine 136(12): 908-922.
44. Szebeni J, Baranyi L, Savay S, Milosevits J, Bunger R, Laverman P, Metselaar JM, Storm G, Chanan-Khan A, Liebes L, Muggia FM, Cohen R, Barenholz Y, Alving CR. 2002. Role of complement activation in hypersensitivity reactions to doxil and hynic PEG liposomes: Experimental and clinical studies. Journal of Liposome Research 12(1-2):165-172.
45. van Lent PL, Grevers L, Lubberts E, de Vries TJ, Nabbe KC, Verbeek S, Oppers B, Sloetjes A, Blom AB, van den Berg WB. 2006. Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: Uncoupling of cartilage damage from bone erosion and joint inflammation. Arthritis and Rheumatism 54(12):3868-3877.
46. van Lent PL, Holthuysen AE, van den Bersselaar LA, van Rooijen N, Joosten LA, van de Loo FA, van de Putte LB, van den Berg WB. 1996. Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis. Arthritis and Rheumatism 39(9):1545-1555.
47. van Lent PL, van den Bersselaar L, Grutters GJ, van den Berg WB. 1989. Fate of antigen after intravenous and intraarticular injection into mice. Role of molecular weight and charge. Journal of Rheumatology 16(10):1295-1303.
48. van Lent PL, van den Bersselaar L, van den Hoek AE, van de Ende M, Dijkstra CD, van Rooijen N, van de Putte LB, van den Berg WB. 1993. Reversible depletion of synovial lining cells after intra-articular treatment with liposome-encapsulated dichloromethylene diphosphonate. Rheumatology International 13(1):21-30.
49. van Lent PL, van den Bersselaar LA, van den Hoek AE, van de Loo AA, van den Berg WB. 1992. Cationic immune complex arthritis in mice - a new model. Synergistic effect of complement and interleukin-1. American Journal of Pathology 140(6):1451-1461.
50. Van Meurs JB, Van Lent PL, Joosten LA, Van der Kraan PM, Van den Berg WB. 1997. Quantification of mRNA levels in joint capsule and articular cartilage of the murine knee joint by RTPCR: Kinetics of stromelysin and IL-1 mRNA levels during arthritis. Rheumatology International 16(5):197-205.
51. van Rooijen N, van Kesteren-Hendrikx E. 2002. Clodronate liposomes: Perspectives in research and therapeutics. Journal of Liposome Research 12(1-2):81-94.
52. Vertut-Doi A, Ishiwata H, Miyajima K. 1996. Binding and uptake of liposomes containing a poly(ethylene glycol) derivative of cholesterol (stealth liposomes) by the macrophage cell line J774: Influence of PEG content and its molecular weight. Biochimica et Biophysica Acta 1278(1):19-28.
53. Watson-Clark RA, Banquerigo ML, Shelly K, Hawthorne MF, Brahn E. 1998. Model studies directed toward the application of boron neutron capture therapy to rheumatoid arthritis: Boron delivery by liposomes in rat collagen-induced arthritis. Proceedings of the National Academy of Sciences of the USA 95(5):2531-2534.
54. Wu J, Chang SJ, Chuang KS, Hsueh YW, Yeh KC, Wang JN, Tsai WP. 2007. Dose evaluation of boron neutron capture synovectomy using the THOR epithermal neutron beam: A feasibility study. Physics in Medicine and Biology 52(6):1747-1756.
55. Yanch JC, Shortkroff S, Shefer RE, Johnson S, Binello E, Gierga D, Jones AG. 1999. Boron neutron capture synovectomy: Treatment of rheumatoid arthritis based on B-10(n,alpha)Li-7 nuclear reaction. Medical Physics 26:364-375.
56. Yanni G, Whelan A, Feighery C, Bresnihan B. 1994. Synovial tissue macrophages and joint erosion in rheumatoid arthritis. Annals of Rheumatic Disease 53(1):39-44.
57. Zvaifler NJ. 1995. Macrophages and the synovial lining. Scandinavian Journal of Rheumatology 101(Suppl.):67-75.