Gender-based differences in drug prescription: Relation to adverse drug reactions

Pharmacology

Volumn 84, Issue 6, 2009, Pages 333-339

  Zopf, Y ^a   Rabe, C ^a   Neubert, A ^b   Janson, C ^a   Brune, K ^a   Hahn, E G ^a   Dormann, H ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Adverse drug reactions, risk; Drug prescription; Gender differences

Indexed keywords

ANABOLIC AGENT; ANTHELMINTIC AGENT; ANTIANGINA PECTORIS AGENT; ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ANTIDIABETIC AGENT; ANTIFUNGAL AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; ANTIPROTOZOAL AGENT; ANTIPRURITIC AGENT; ANTIRHEUMATIC AGENT; ANTITHROMBOCYTIC AGENT; ANTIVIRUS AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CONTRACEPTIVE AGENT; CORTICOSTEROID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FERTILITY PROMOTING AGENT; FIBRINOLYTIC AGENT; MUSCLE RELAXANT AGENT; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SEX HORMONE; THYROID HORMONE; UNINDEXED DRUG; VACCINE; VASODILATOR AGENT;

ADULT; AGED; ARTICLE; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCRIPTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; UNSPECIFIED SIDE EFFECT;

ADVERSE DRUG REACTION REPORTING SYSTEMS; DRUG PRESCRIPTIONS; DRUG TOXICITY; FEMALE; GERMANY; HUMANS; ISRAEL; MALE; PRESCRIPTION DRUGS; PROSPECTIVE STUDIES; SEX FACTORS;

EID: 70350048535     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000248311     Document Type: Article

References (27)

1. Domecq C, Naranjo CA, Ruiz I, Busto U: Sex-related variations in the frequency and characteristics of adverse drug reactions. Int J Clin Pharmacol Ther Toxicol 1980; 18: 362-366.
2. Franconi F, Brunelleschi S, Steardo L, Cuomo V: Gender differences in drug responses. Pharmacol Res 2007; 55: 81-95.
3. Hoigne R, Sollberger J, Zoppi M, Muller U, Hess T, Fritschy D, et al: Significance of age, sex, kidney function, atopy and number of prescriptions for the occurrence of adverse drug reactions, studied by multivariate statistical methods: results from the Comprehensive Hospital Drug Monitoring Berne (CHDMB) (in German). Schweiz Med Wochenschr 1984; 114: 1854-1857.
4. Zopf Y, Rabe C, Neubert A, Gassmann KG, Rascher W, Hahn EG, et al: Women encounter ADRs more often than do men. Eur J Clin Pharmacol 2008; 64: 999-1004.
5. Zopf Y, Rabe C, Neubert A, Hahn EG, Dormann H: Risk factors associated with adverse drug reactions following hospital admission: a prospective analysis of 907 patients in two German university hospitals. Drug Saf 2008; 31: 789-798.
6. Beierle I, Meibohm B, Derendorf H: Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol Ther 1999; 37: 529-547.
7. Drici MD, Clement N: Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome. Drug Saf 2001; 24: 575-585.
8. Gleiter CH, Gundert-Remy U: Gender differences in pharmacokinetics. Eur J Drug Metab Pharmacokinet 1996; 21: 123-128.
9. Lang DM, Alpern MB, Visintainer PF, Smith ST: Gender risk for anaphylactoid reaction to radiographic contrast media. J Allergy Clin Immunol 1995; 95: 813-817.
10. Wolbrette D: Gender differences in the proarrhythmic potential of QT-prolonging drugs. Curr Womens Health Rep 2002; 2: 105-109.
11. Hohmann AA: Gender bias in psychotropic drug prescribing in primary care. Med Care 1989; 27: 478-490.
12. Tran C, Knowles SR, Liu BA, Shear NH: Gender differences in adverse drug reactions. J Clin Pharmacol 1998; 38: 1003-1009.
13. Dormann H: Model-Projekt OntoDrug: Befundpräsentation Arzneimittelnebenwirkung. Dtsch Med Wochenschr 2006; 34/35.
14. WHO CCfDSM: Guidelines for ATC classification and DDD assignment 2006.
15. Edwards IR, Aronson JK: Adverse drug reactions: definitions, diagnosis, and management. Lancet 2000; 356: 1255-1259.
16. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al: A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-245.
17. Dormann H, Muth-Selbach U, Krebs S, Criegee-Rieck M, Tageder I, Schneider HT, et al: Incidence and costs of adverse drug reactions during hospitalisation: computerised monitoring versus stimulated spontaneous reporting. Drug Saf 2000; 22: 161-168.
18. Yonkers KA, Kando JC, Cole JO, Blumenthal S: Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. Am J Psychiatry 1992; 149: 587-595.
19. Simpson JM, Bateman DN, Rawlins MD: Using the Adverse Reactions Register to study the effects of age and sex on adverse drug reactions. Stat Med 1987; 6: 863-867.
20. Rabkin J, Quitkin F, Harrison W, Tricamo E, McGrath P: Adverse reactions to monoamine oxidase inhibitors. Part I. A comparative study. J Clin Psychopharmacol 1984; 4: 270-278.
21. Suh DC, Woodall BS, Shin SK, Hermes-De Santis ER: Clinical and economic impact of adverse drug reactions in hospitalized patients. Ann Pharmacother 2000; 34: 1373-1379.
22. Neutel CI, Maxwell CJ, Appel WC: Differences between males and females in risk of NSAID-related severe gastrointestinal events. Pharmacoepidemiol Drug Saf 1999; 8: 501-507.
23. Figueras A, Capella D, Castel JM, Laorte JR: Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs: a report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations. Eur J Clin Pharmacol 1994; 47: 297-303.
24. Pleym H, Spigset O, Kharasch ED, Dale O: Gender differences in drug effects: implications for anesthesiologists. Acta Anaesthesiol Scand 2003; 47: 241-259.
25. Walker JS, Carmody JJ: Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen. Anesth Analg 1998; 86: 1257-1262.
26. Overholser BR, Kays MB, Forrest A, Sowinski KM: Sex-related differences in the pharmacokinetics of oral ciprofloxacin. J Clin Pharmacol 2004; 44: 1012-1022.
27. Anderson GD: Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics. J Womens Health (Larchmt) 2005; 14: 19-29.