메뉴 건너뛰기




Volumn 72, Issue 6, 2009, Pages 370-376

Metformin, estrogen replacement therapy and gonadotropin inhibition fail to improve insulin sensitivity in a girl with aromatase deficiency

Author keywords

Androgen excess; Aromatase deficiency; Estrogen replacement; Insulin insensitivity; Metabolic syndrome

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; CONJUGATED ESTROGEN; FOLLITROPIN; GONADOTROPIN; METFORMIN; TESTOSTERONE; TRIPTORELIN;

EID: 70350046653     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000249165     Document Type: Article
Times cited : (24)

References (32)
  • 1
    • 1842535925 scopus 로고    scopus 로고
    • Physiology and pathophysiology of estrogens. Lessons from pediatric patients with complete aromatase deficiency
    • Belgorosky A, Rivarola MA: Physiology and pathophysiology of estrogens. Lessons from pediatric patients with complete aromatase deficiency. Endocrinologist 2004; 14: 1-8.
    • (2004) Endocrinologist , vol.14 , pp. 1-8
    • Belgorosky, A.1    Rivarola, M.A.2
  • 3
    • 0037291609 scopus 로고    scopus 로고
    • Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency
    • Takeda K, Toda K, Saibara T, Nakagawa M, Saika K, Onishi T, Sugiura T, Shizuta Y: Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency. J Endocrinol 2003; 17: 237-246.
    • (2003) J Endocrinol , vol.17 , pp. 237-246
    • Takeda, K.1    Toda, K.2    Saibara, T.3    Nakagawa, M.4    Saika, K.5    Onishi, T.6    Sugiura, T.7    Shizuta, Y.8
  • 4
    • 0032499704 scopus 로고    scopus 로고
    • Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the CYP19 gene
    • Fisher CR, Graves KH, Parlow AF, Simpson ER: Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the CYP19 gene. Proc Natl Acad Sci USA 1998; 95: 6965-6970.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6965-6970
    • Fisher, C.R.1    Graves, K.H.2    Parlow, A.F.3    Simpson, E.R.4
  • 7
    • 35448942716 scopus 로고    scopus 로고
    • The cytochome P450 aromatase lacking exon 5 is associated with a phenotype of non-classic aromatase deficiency, and it is also present in normal human steroidogenic tissues
    • Pepe C, Saraco, Baquedano S, Guercio G, Vaiani E, Marino R, Pandey A, Flück C, Rivarola MA, Belgorosky A: The cytochome P450 aromatase lacking exon 5 is associated with a phenotype of non-classic aromatase deficiency, and it is also present in normal human steroidogenic tissues. Clin Endocrinol (Oxf) 2007; 67: 698-705.
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 698-705
    • Pepe, C.1    Saraco, B.S.2    Guercio, G.3    Vaiani, E.4    Marino, R.5    Pandey, A.6    Flück, C.7    Rivarola, M.A.8    Belgorosky, A.9
  • 8
    • 0344442680 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatasedeficient girl who is a compound heterozygote for two new point mutations of the CYP19 gene
    • Belgorosky A, Pepe C, Marino R, Guercio G, Saraco N, Vaiani E, Rivarola MA: Hypothalamic- pituitary-ovarian axis during infancy, early and late prepuberty in an aromatasedeficient girl who is a compound heterozygote for two new point mutations of the CYP19 gene. J Clin Endocrinol Metab 2003; 88: 5127-5131.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5127-5131
    • Belgorosky, A.1    Pepe, C.2    Marino, R.3    Guercio, G.4    Saraco, N.5    Vaiani, E.6    Rivarola, M.A.7
  • 9
    • 0031726118 scopus 로고    scopus 로고
    • Female pseudohermaphroditism associated with a novel homozygous G-to-A (V370-to-M) substitution in the P-450 aromatase gene
    • Ludwig M, Beck A, Wickert L, Bolkenius U, Tittel B, Hinkel K, Bidlingmaier F: Female pseudohermaphroditism associated with a novel homozygous G-to-A (V370-to-M) substitution in the P-450 aromatase gene. J Pediatr Endocrinol Metab 1998; 11: 657-664.
    • (1998) J Pediatr Endocrinol Metab , vol.11 , pp. 657-664
    • Ludwig, M.1    Beck, A.2    Wickert, L.3    Bolkenius, U.4    Tittel, B.5    Hinkel, K.6    Bidlingmaier, F.7
  • 10
    • 0031154045 scopus 로고    scopus 로고
    • Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: Impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhood
    • Mullis PE, Yoshimura N, Kuhlmann B, Lippuner K, Jaeger P, Harada H: Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhood. J Clin Endocrinol Metab 1997; 82: 1739-1745.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1739-1745
    • Mullis, P.E.1    Yoshimura, N.2    Kuhlmann, B.3    Lippuner, K.4    Jaeger, P.5    Harada, H.6
  • 11
    • 0028792229 scopus 로고
    • Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    • Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K: Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 1995; 80: 3689-3698.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3689-3698
    • Morishima, A.1    Grumbach, M.M.2    Simpson, E.R.3    Fisher, C.4    Qin, K.5
  • 12
    • 0028298216 scopus 로고
    • A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom)
    • Conte FA, Grumbach MM, Ito Y, Fisher CR, Simpson ER: A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom). J Clin Endocrinol Metab 1994; 78: 1287-1292.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 1287-1292
    • Conte, F.A.1    Grumbach, M.M.2    Ito, Y.3    Fisher, C.R.4    Simpson, E.R.5
  • 13
    • 0027133452 scopus 로고
    • Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries
    • Ito Y, Fisher CR, Conte FA, Grumbach MM, Simpson ER: Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. Proc Natl Acad Sci USA 1993; 90: 11673-11677.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11673-11677
    • Ito, Y.1    Fisher, C.R.2    Conte, F.A.3    Grumbach, M.M.4    Simpson, E.R.5
  • 14
    • 0025772011 scopus 로고
    • A new cause of female pseudohermaphroditism: Placental aromatase deficiency
    • Shozu M, Akasofu K, Harada T, Kubota Y: A new cause of female pseudohermaphroditism: placental aromatase deficiency. J Clin Endocrinol Metab 1991; 72: 560-566.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 560-566
    • Shozu, M.1    Akasofu, K.2    Harada, T.3    Kubota, Y.4
  • 17
    • 0033326235 scopus 로고    scopus 로고
    • Aromatase deficiency caused by a novel P450arom gene mutation: Impact of absent estrogen production on serum gonadotropin concentration in a boy
    • Deladoey J, Fluck C, Bex M, Yoshimura N, Harada N, Mullis PE: Aromatase deficiency caused by a novel P450arom gene mutation: impact of absent estrogen production on serum gonadotropin concentration in a boy. J Clin Endocrinol Metab 1999; 84: 4050-4054.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4050-4054
    • Deladoey, J.1    Fluck, C.2    Bex, M.3    Yoshimura, N.4    Harada, N.5    Mullis, P.E.6
  • 19
    • 17444420666 scopus 로고    scopus 로고
    • Effects of estrogen replacement therapy on bone and glucose metabolism in a male with congenital aromatase deficiency
    • Herrmann BL, Janssen OE, Hahn S, Broecker- Preuss M, Mann K: Effects of estrogen replacement therapy on bone and glucose metabolism in a male with congenital aromatase deficiency. Horm Metab Res 2005; 37: 178-183.
    • (2005) Horm Metab Res , vol.37 , pp. 178-183
    • Herrmann, B.L.1    Janssen, O.E.2    Hahn, S.3    Broecker-Preuss, M.4    Mann, K.5
  • 20
    • 0032832015 scopus 로고    scopus 로고
    • Diagnostic criteria for diabetes mellitus and other categories of glucose intolerance 1997 criteria by the expert committee on the diagnosis and classification of diabetes mellitus (ADA), 1998 WHO consultation criteria, and 1985 WHO criteria
    • World Health Organization
    • Puavilai G, Chanprasertyotin S, Sriphrapradaeng A: Diagnostic criteria for diabetes mellitus and other categories of glucose intolerance: 1997 criteria by the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (ADA), 1998 WHO consultation criteria, and 1985 WHO criteria. World Health Organization. Diabetes Res Clin Pract 1999; 44: 21-26.
    • (1999) Diabetes Res Clin Pract , vol.44 , pp. 21-26
    • Puavilai, G.1    Chanprasertyotin, S.2    Sriphrapradaeng, A.3
  • 23
    • 0036364916 scopus 로고    scopus 로고
    • Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women
    • Ryan AS, Nicklas BJ, Berman DM: Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women. Diabetes Care 2002; 25: 127-133.
    • (2002) Diabetes Care , vol.25 , pp. 127-133
    • Ryan, A.S.1    Nicklas, B.J.2    Berman, D.M.3
  • 24
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Hum Reprod 2004; 19: 41-47.
    • (2004) Hum Reprod , vol.19 , pp. 41-47
  • 25
    • 0036090213 scopus 로고    scopus 로고
    • Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: Potential clinical implications
    • Charmandari E, Weise M, Bornstein SR, Eisenhofer G, Keil MF, Chrousos GP, Merke DP: Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: potential clinical implications. J Clin Endocrinol Metab 2002; 87: 2114-2120.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2114-2120
    • Charmandari, E.1    Weise, M.2    Bornstein, S.R.3    Eisenhofer, G.4    Keil, M.F.5    Chrousos, G.P.6    Merke, D.P.7
  • 26
    • 0024584149 scopus 로고
    • The administration of pharmacological doses of testosterone or 19-nortestosterone to normal men is not associated with increased insulin secretion or impaired glucose tolerance
    • Friedl KE, Jones RE, Hannan CJ Jr, Plymate SR: The administration of pharmacological doses of testosterone or 19-nortestosterone to normal men is not associated with increased insulin secretion or impaired glucose tolerance. J Clin Endocrinol Metab 1989; 68: 971-975.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 971-975
    • Friedl, K.E.1    Jones, R.E.2    Hannan Jr., C.J.3    Plymate, S.R.4
  • 27
    • 0034454040 scopus 로고    scopus 로고
    • Timing of prenatal androgen excess determines differential impairment in insulin secretion and action in adult female rhesus monkeys
    • Eisner JR, Dumesic DA, Kemnitz JW, Abbott DH: Timing of prenatal androgen excess determines differential impairment in insulin secretion and action in adult female rhesus monkeys. J Clin Endocrinol Metab 2000; 85: 1206-1210.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1206-1210
    • Eisner, J.R.1    Dumesic, D.A.2    Kemnitz, J.W.3    Abbott, D.H.4
  • 28
    • 0031028152 scopus 로고    scopus 로고
    • Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood
    • Dumesic DA, Abbott DH, Eisner JR, Goy RW: Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood. Fertil Steril 1997; 67: 155-163.
    • (1997) Fertil Steril , vol.67 , pp. 155-163
    • Dumesic, D.A.1    Abbott, D.H.2    Eisner, J.R.3    Goy, R.W.4
  • 29
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks S: Polycystic ovary syndrome. N Engl J Med 1995; 333: 853-861.
    • (1995) N Engl J Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 30
    • 34249687212 scopus 로고    scopus 로고
    • Investigation of hypothalamo-pituitary-gonadal axis and glucose intolerance among the first-degree female relatives of women with polycystic ovary syndrome
    • Unlühizarci K, Ozocak M, Tanriverdi F, Atmaca H, Kelestimur F: Investigation of hypothalamo- pituitary-gonadal axis and glucose intolerance among the first-degree female relatives of women with polycystic ovary syndrome. Fertil Steril 2007; 87: 1377-1382.
    • (2007) Fertil Steril , vol.87 , pp. 1377-1382
    • Unlühizarci, K.1    Ozocak, M.2    Tanriverdi, F.3    Atmaca, H.4    Kelestimur, F.5
  • 31
    • 0042421820 scopus 로고    scopus 로고
    • The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis
    • Hewitt KN, Boon WC, Murata Y, Jones ME, Simpson ER: The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis. Endocrinology 2003; 144: 3895-3903.
    • (2003) Endocrinology , vol.144 , pp. 3895-3903
    • Hewitt, K.N.1    Boon, W.C.2    Murata, Y.3    Jones, M.E.4    Simpson, E.R.5
  • 32
    • 1642505593 scopus 로고    scopus 로고
    • Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse
    • Hewitt KN, Pratis K, Jones ME, Simpson ER: Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse. Endocrinology 2004; 145: 1842-1848.
    • (2004) Endocrinology , vol.145 , pp. 1842-1848
    • Hewitt, K.N.1    Pratis, K.2    Jones, M.E.3    Simpson, E.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.