Multivariate statistical analyses demonstrate unique host immune responses to single and dual lentiviral infection

PLoS ONE

Volumn 4, Issue 10, 2009, Pages

  Roy, Sunando ^a   Lavine, Jennie ^a   Chiaromonte, Francesca ^a   Terwee, Julie ^b   VandeWoude, Sue ^b   Bjornstad, Ottar ^a,c   Poss, Mary ^a,c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; COVARIANCE; CROSS INFECTION; DISCRIMINANT ANALYSIS; FELINE IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; LYMPHOCYTE COUNT; MULTIVARIATE ANALYSIS; MULTIVARIATE ANALYSIS OF VARIANCE; NONHUMAN; PROTEIN EXPRESSION; SUPERINFECTION; VIRUS INFECTION; ANIMAL; BIOSYNTHESIS; CAT; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; LENTIVIRINAE; METABOLISM; PRINCIPAL COMPONENT ANALYSIS; STATISTICAL ANALYSIS; STATISTICAL MODEL;

ANIMALIA; FELINE IMMUNODEFICIENCY VIRUS; FELIS CATUS; HUMAN IMMUNODEFICIENCY VIRUS;

ANIMALS; ANTIGENS, CD8; CATS; DATA INTERPRETATION, STATISTICAL; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; IMMUNODEFICIENCY VIRUS, FELINE; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-4; LENTIVIRUS; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS;

EID: 70350010199     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007359     Document Type: Article

References (32)

1. Travers K, Mboup S, Marlink R, Gueye-Nidaye A, Siby T, et al. (1995) Natural protection against HIV-1 infection provided by HIV-2. Science 268: 1612-1615.
2. Koff WC, Johnson PR, Watkins DI, Burton DR, Lifson JD, et al. (2006) HIV vaccine design: insights from live attenuated SIV vaccines. Nat Immunol 7: 19-23.
3. Terwee JA, Carlson JK, Sprague WS, Sondgeroth KS, Shropshire SB, et al. (2008) Prevention of immunodeficiency virus induced CD4+ T-cell depletion by prior infection with a non-pathogenic virus. Virology 377: 63-70.
4. VandeWoude S, Hageman CA, O'Brien SJ, Hoover EA (2002) Nonpathogenic lion and puma lentiviruses impart resistance to superinfection by virulent feline immunodeficiency virus. J Acquir Immune Defic Syndr 29: 1-10.
5. Friedrich TC, Watkins DI (2008) Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus. Curr Opin HIV AIDS 3: 393-398.
6. Lifson JD, Rossio JL, Piatak M Jr, Parks T, Li L, et al. (2001) Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol 75: 10187-10199.
7. de Rozieres S, Mathiason CK, Rolston MR, Chatterji U, Hoover EA, et al. (2004) Characterization of a highly pathogenic molecular clone of feline immunodeficiency virus clade C. J Virol 78: 8971-8982.
8. Burkhard MJ, Dean GA (2003) Transmission and immunopathogenesis of FIV in cats as a model for HIV. Curr HIV Res 1: 15-29.
9. VandeWoude S, Apetrei C (2006) Going wild: lessons from naturally occurring T-lymphotropic lentiviruses. Clin Microbiol Rev 19: 728-762.
10. Poss M, Ross HA, Painter SL, Holley DC, Terwee JA, et al. (2006) Feline lentivirus evolution in cross-species infection reveals extensive G-to-A mutation and selection on key residues in the viral polymerase. J Virol 80: 2728-2737.
11. Terwee JA, Yactor JK, Sondgeroth KS, Vandewoude S (2005) Puma lentivirus is controlled in domestic cats after mucosal exposure in the absence of conventional indicators of immunity. J Virol 79: 2797-2806.
12. Biek R, Rodrigo AG, Holley D, Drummond A, Anderson CR Jr, et al. (2003) Epidemiology, genetic diversity, and evolution of endemic feline immunodeficiency virus in a population of wild cougars. J Virol 77: 9578-9589.
13. Biek R, Ruth TK, Murphy KM, Anderson CR Jr, Johnson M, et al. (2006) Factors associated with microparasite seroprevalence and exposure risk in Rocky Mountain cougars. J Wildlife Disease 42: 606-615.
14. Biek R, Ruth TK, Murphy KM, Anderson CR Jr, Poss M (2006) Examining effects of persistent retrovirus infection on fitness and pathogen susceptibility in a natural feline host. Canadian Journal of Zoology 84: 365-373.
15. Genser B, Cooper P, Yazdanbakhsh M, Barreto M, Rodrigues L (2007) A guide to modern statistical analysis of immunological data. BMC Immunology 8: 27.
16. Keil D, Luebke RW, Ensley M, Gerard PD, Pruett SB (1999) Evaluation of multivariate statistical methods for analysis and modeling of immunotoxicology data. Toxicol Sci 51: 245-258.
17. Collette A, Bagot S, Ferrandiz ME, Cazenave PA, Six A, et al. (2004) A profound alteration of blood TCRB repertoire allows prediction of cerebral malaria. J Immunol 173: 4568-4575.
18. Lionel A, de Seze J, Didier L, Sandrine F-N, Sylvain D, et al. (2005) Evolution of self-reactive IgG antibody repertoires in patients with relapsing-remitting multiple sclerosis. Immunology Letters 97: 55-62.
19. de Monte M, Nonnenmacher H, Brignon N, Ullmann M, Martin JP (2002) A multivariate statistical analysis to follow the course of disease after infection of cats with different strains of the feline immunodeficiency virus (FIV). J Virol Methods 103: 157-170.
20. Dray S, Pettorelli N, Chessel D (2003) Multivariate Analysis of Incomplete Mapped Data. Transactions in GIS 7: 411-422.
21. Everitt B (2005) An R and S-PLUS Companion to Multivariate Analysis; Casella G, Fienberg S, Olkin I, eds. London: Springer-Verlag.
22. Seber GAF (2004) Multivariate Observations. NY: Wiley.
23. Gnanadesikan R (1997) Methods for Statistical Data Analysis of Multivariate Observations. NY: Wiley.
24. Olson C (1976) On choosing a test statistic in multivariate analysis of variance. Psychological Bulletin 83: 579-586.
25. Olson C (1974) Comparative Robustness of Six Tests in Multivariate Analysis of Variance. Journal of the American Statistical Association 69: 894-908.
26. Krzanowski WJ (1988) Principles of Multivariate Analysis: a user's perspective. Oxford: Clarendon Press.
27. Fisher RA (1936) The Use of Multiple Measurements in Taxonomic Problems. The Annals of Eugenics 7: 179-188.
28. Gollob KJ, Antonelli LR, Faria DR, Keesen TS, Dutra WO (2008) Immunoregulatory mechanisms and CD4-CD8- (double negative) T cell subpopulations in human cutaneous leishmaniasis: a balancing act between protection and pathology. Int Immunopharmacol 8: 1338-1343.
29. Samaradasa W (2004) Generalized Inference in Repeated Measures: Exact Methods in MANOVA and Mixed Models. NY: Wiley.
30. Ramsay J, Silverman BW (2005) Functional Data Analysis. NY: Springer.
31. McLachlan GJ (1992) Discriminant Analysis and Statistical Pattern Recognition. NY: Wiley.
32. Dabo-Niang S, Ferraty F (2008) Functional and Operatorial Statistics; Dabo-Niang S, Ferraty F, eds. Heidelberg: Physica-Verlag.