Evaluation of multivariate statistical methods for analysis and modeling of immunotoxicology data

Toxicological Sciences

Volumn 51, Issue 2, 1999, Pages 245-258

  Keil, Deborah ^a,d   Luebke, Robert W ^b   Ensley, Michael ^c   Gerard, Patrick D ^c   Pruett, Stephen B ^a,e  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c MISSISSIPPI STATE UNIVERSITY   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

Correlation matrices; Cyclosporin A; Dexamethasone; Immunotoxicology data sets; Multivariate analysis

Indexed keywords

CYCLOSPORIN A; DEXAMETHASONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EVALUATION; FEMALE; HOST RESISTANCE; IMMUNOTOXICITY; INFORMATION PROCESSING; MOUSE; MULTIPLE REGRESSION; MULTIVARIATE ANALYSIS; NONHUMAN; PREDICTION; PRINCIPAL COMPONENT ANALYSIS; RANDOMIZATION; STATISTICAL ANALYSIS; STATISTICAL MODEL;

ANIMALS; CYCLOSPORINE; DATA INTERPRETATION, STATISTICAL; DEXAMETHASONE; FEMALE; HUMANS; IMMUNE SYSTEM; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; RANDOM ALLOCATION; REGRESSION ANALYSIS; TOXICOLOGY;

ANIMALIA;

EID: 0032702281     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/51.2.245     Document Type: Article

References (19)

1. Belsley, D. A., Kuh, E., and Welsch, R. E. (1980). Regression Diagnostics: Identifying Influential Data and Sources of Colinearity, pp. 6-84. John Wiley and Sons, New York.
2. Day, R. W., and Quinn, G. P. (1989). Comparisons of treatments after an analysis of variance in ecology. Ecological Monographs 59, 433-463.
3. Fujihashi, K., McGhee, J. R., Beagley, K. W., McPherson, D. T., McPherson, S. A., Huang, C.-M., and Kiyono, H. (1993). Cytokine-specific ELISPOT assay: Single cell analysis of IL-2-, IL-4-, and IL-6-producing cells. J. Immunol. Methods 160, 181-189.
4. Hair, J. F., Anderson, R. E., Tatham, R. L., and Black, W. C. (1995). Multivariate Data Analysis, pp. 32-75 and 364-404. Prentice Hall, Englewood Cliffs, NJ.
5. Haziot, A., Ferrero, E., Kontgen, F., Hijiya, N., Yamamoto, S., Silver, J., Stewart, C. L., and Goyert, S. M. (1996). Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 4, 407-414.
6. Holsapple, M. P., White, K. L., McCay, J. A., Bradley, S. G., and Munson, A. E. (1988). An immunotoxicological evaluation of 4,4′-thiobis-(6-t-butyl-m-cresol) in female B6C3F1 mice. 2. Humoral and cell-mediated immunity, macrophage function, and host resistance. Fundam. Appl. Toxicol. 10, 701-716.
7. Kundig, T. M., Schorle, H., Bachmann, M. F., Hengartner, H., Zinkernagel, R. M., and Horak, I. (1993). Immune responses in interleukin-2-deficient mice. Science 262, 1059-1061.
8. Lebrec, H., Blot, C., Pequet, S., Roger, R., Bohuon, C., and Pallardy, M. (1994). Immunotoxicological investigation using pharmaceutical drugs: In vivo evaluation of immune effects. Fundam. Appl. Toxicol. 23, 159-168.
9. Luster, M. I., Munson, A. E., Thomas, P. T., Holsapple, M. P., Fenters, J. D., White, K. L., Lauer, L. D., Germolec, D. R., Rosenthal, G. J., and Dean, J. H. (1988). Methods evaluation: Development of a testing battery to assess chemical-induced immunotoxicity. National Toxicology Program's guidelines for immunotoxicity evaluation in mice. Fundam. Appl. Toxicol. 10, 2-19.
10. Luster, M. I., Portier, C., Pait, D. G., Rosenthal, G. J., Germolec, D. R., Corsini, E., Blaylock, B. L., Pollock, P., Kouchi, Y., Craig, W., White, K. L., Munson, A. E., and Comment, C. E. (1993). Risk assessment in immunotoxicology: II. Relationships between immune and host resistance tests. Fundam. Appl. Toxicol. 21, 71-82.
11. Luster, M. I., Portier, C., Pait, D. G., White, K. L., Gennings, C., Munson, A. E., and Rosenthal, G. J. (1992). Risk Assessment in Immunotoxicology. I. Sensitivity and predictability of immune tests. Fundam. Appl. Toxicol. 18, 200-210.
12. McClave, J. T., and Benson, P. G. (1991). Statistics for Business and Economics, pp. 294-295. Dellen and Macmillan, San Francisco and New York.
13. Norbury, C. C., Hewlett, L. J., Prescott, A. R., Shastri, N., and Watts, C. (1995). Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity 3, 783-791.
14. Padgett, E. L., and Pruett, S. B. (1992). Evaluation of nitrite production by human monocyte-derived macrophages. Biochem. Biophys. Res. Commun. 186, 775-781.
15. Rohlf, F. J. (1988). Numerical Taxonomy and Multivariate Analysis System. Exeter Publishing, Setauket, New York.
16. Schijns, V. E. C. J., Haagmans, B. L., Rijke, E. O., Huang, S., Aguet, R., and Horzinek, M. C. (1994). IFN-γ receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses. J. Immunol. 153, 2029-2037.
17. Sikorski, E. E., McCay, J. A., White, K. L., Bradley, S. G., and Munson, A. E. (1989). Immunotoxicity of the semiconductor gallium arsenide in female B6C3F1 mice. Fundam. Appl. Toxicol. 13, 843-858.
18. van der Heyde, H. C., Pepper, B., Batchelder, J., Cigel, F., and Weidanz, W. P. (1997). The time course of selected malarial infections in cytokine-deficient mice. Exp. Parasitol. 85, 206-213.
19. Wu, W.-J., Wolcott, R. M., and Pruett, S. B. (1994). Ethanol decreases the number and activity of splenic natural killer cells in a mouse model for binge drinking. J. Pharmacol. Exp. Ther. 271, 722-729.