The effect of dose on 2,3,7,8-TCDD tissue distribution, metabolism and elimination in CYP1A2 (-/-) knockout and C57BL/6N parental strains of mice

Toxicology and Applied Pharmacology

Volumn 241, Issue 1, 2009, Pages 119-126

  Hakk, Heldur ^a   Diliberto, Janet J ^b   Birnbaum, Linda S ^c  

^a USDA ARS Red River Valley Agricultural Research Center   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; CYP1A2; Knockout mice; Metabolism; Mouse major urinary protein; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CARRIER PROTEIN; CYTOCHROME P450 1A2;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMBUSTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPOSURE; FECES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METABOLITE; MOUSE; MOUSE STRAIN; NONHUMAN; TISSUE DISTRIBUTION; URINARY EXCRETION;

ADIPOSE TISSUE; ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FECES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEINS; TETRACHLORODIBENZODIOXIN; TISSUE DISTRIBUTION;

MUS;

EID: 70350005205     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.08.009     Document Type: Article

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