Tissue distribution, excretion, and metabolism of 1,2,7,8-tetrachlorodibenzo-p-dioxin in the rat

Chemosphere

Volumn 42, Issue 8, 2001, Pages 975-983

  Hakk, Heldur ^a   Larsen, Gerald ^a   Feil, Vernon ^a  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Biotransformation; Enterohepatic circulation; Environmental contaminants; Mass spectrometry; Pharmacokinetics; Proton NMR

Indexed keywords

1,4 DIOXANE DERIVATIVE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ANIMAL EXPERIMENT; ARTICLE; BIOACCUMULATION; BIOTRANSFORMATION; ENTEROHEPATIC CIRCULATION; MALE; NONHUMAN; POLLUTION; RAT; TISSUE DISTRIBUTION;

ANIMALS; BIOTRANSFORMATION; ENVIRONMENTAL POLLUTANTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, SPRAGUE-DAWLEY; TETRACHLORODIBENZODIOXIN;

MAMMALIA;

EID: 0035126544     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0045-6535(00)00131-4     Document Type: Article

References (26)

1. 14C]tetrachlorodibenzo-p-dioxin in rats
2. Evidence for involvement of non-biliary excretion into intestines in the formation of methylsulfonyl-containing metabolites of 2chloro-N-isopropylacetanilide by swine and rats
3. Synthesis of specific polychlorinated dibenzo-p-dioxins
4. Identification of a hydroxylated metabolite of 1278-TCDD in calf plasma following an oral dose
5. Metabolism of hydroxydibenzofurans, methoxydibenzofurans, acetoxydibenzofurans, and nitrodibenzofurans by Sphingomonas spp Strain HH96
6. Transport of niacin and niacinamide in perfused rat intestine
7. Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat
8. Structure-dependant, competitive interactions of hydroxy-polychlorobiphenyls, -dibenzop-dioxins, and -dibenzofurans with human transthyretin
9. Pharmacokinetics of Albendazole in sheep
10. UDP glucuronyl transferase and phenolsulfotransferase in vivo and in vitro conjugation of harmol and harmalol
11. Metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mammalian systems
12. The toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mammalian systems
13. Identification of NIH-shifted metabolites of 1,3,7,8-tetrachlorodibenzo-p-dioxin in the rat by comparison with synthesized standards
14. 14C-TCDD in a TCDD-susceptible and a TCDD-resistant rat strain
15. The metabolism of TCDD in the dog and rat
16. Structure elucidation of mammalian TCDD-metabolites
17. Pharmacokinetics of 2,3,7,8TCDD in man
18. The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat
19. CYP1A2 Knockout mice: Decreased hepatic microsomal localization of TCDD
20. Identification of metabolites of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) formed upon incubation with isolated rat hepatocytes
21. Exposure assessment: Measurement of dioxins and related chemicals in human tissues
22. Synthesis of oxygenated derivatives of 2,3,7,8-tetrachlorodibenzo-p-dioxin
23. In situ intestinal absorption of 2-chloro-N-isopropyl acetanilide (propachlor) and non-biliary excretion of metabolites into the intestinal tract of rats, pigs and chickens
24. Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450 to the cytochrome and inhibition of its estradiol 2-hydroxylase activity
25. Biphenyl metabolism in isolated rat hepatocytes Effect of induction and nature of the conjugates
26. Metabolism of dibenzo-p-dioxin by Spingomonas sp. strain RWl