Increased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer

International Journal of Colorectal Disease

Volumn 24, Issue 11, 2009, Pages 1261-1269

  McDowell, Dermot T ^a   Smith, Fraser M ^a   Reynolds, John V ^a   Maher, Stephen G ^a   Adida, Collette ^b   Crotty, Paul ^c   Gaffney, Eoin F ^a   Hollywood, Donal ^a   Mehigan, Brian ^a   Stephens, Richard B ^a   Kennedy, M J ^a  

^a ST JAMES S HOSPITAL   (Ireland)

^b ROTUNDA HOSPITAL   (Ireland)

^c ADELAIDE AND MEATH HOSPITAL   (Ireland)

Author keywords

Apoptosis; Chemoradiotherapy; Rectal cancer; Survivin; Tumour regression grade

Indexed keywords

FLUOROURACIL; KI 67 ANTIGEN; MESSENGER RNA; SURVIVIN;

ADJUVANT CHEMOTHERAPY; APOPTOSIS; ARTICLE; CANCER MORPHOLOGY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CELL PROLIFERATION; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG RESPONSE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LYMPH NODE METASTASIS; NICK END LABELING; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CANCER; TREATMENT RESPONSE; TUMOR BIOPSY; TUMOR CELL; TUMOR REGRESSION;

APOPTOSIS; BIOPSY; CELL PROLIFERATION; CHEMOTHERAPY, ADJUVANT; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KI-67 ANTIGEN; LYMPH NODES; MICROTUBULE-ASSOCIATED PROTEINS; NEOADJUVANT THERAPY; NEOPLASM STAGING; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; STAINING AND LABELING;

EID: 70350004794     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-009-0755-6     Document Type: Article

References (39)

1. Kapiteijn E, Marijnen CA, Nagtegaal ID et al (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 9:638-646
2. Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 17:1731-740
3. Crane CH, Skibber JM, Feig BW et al (2003) Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma. Cancer 2:517-524
4. Gerard A, Buyse M, Nordlinger B et al (1988) Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC). Ann Surg 5:606-614
5. Reerink O, Karrenbeld A, Plukker JT et al (2004) Molecular prognostic factors in locally irresectable rectal cancer treated preoperatively by chemo-radiotherapy. Anticancer Res 2C:1217-221
6. Valentini V, Coco C, Picciocchi A et al (2002) Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients. Int J Radiat Oncol Biol Phys 3:664-674
7. Guillem JG, Chessin DB, Cohen AM et al (2005) Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer. Ann Surg 5:829-836 discussion 836-838
8. Bouzourene H, Bosman FT, Seelentag W et al (2002) Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer 4:1121-1130
9. Ruo L, Tickoo S, Klimstra DS et al (2002) Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy. Ann Surg 1:75-81
10. Van Den Brink M, Van Den Hout WB, Stiggelbout AM et al (2004) Cost-utility analysis of preoperative radiotherapy in patients with rectal cancer undergoing total mesorectal excision: A study of the Dutch Colorectal Cancer Group. J Clin Oncol 2:244-253
11. Rullier E, Goffre B, Bonnel C et al (2001) Preoperative radiochemotherapy and sphincter-saving resection for T3 carcinomas of the lower third of the rectum. Ann Surg 5:633-640
12. Dahlberg M, Stenborg A, Pahlman L et al (2002) Cost-effectiveness of preoperative radiotherapy in rectal cancer: Results from the Swedish Rectal Cancer Trial. Int J Radiat Oncol Biol Phys 3:654-660
13. Habr-Gama A, Perez RO, Nadalin W et al (2004) Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: Long-term results. Ann Surg 4:711-717 discussion 717-8
14. Smith FM, Stephens RB, Kennedy MJ et al (2005) P53 abnormalities and outcomes in colorectal cancer: A systematic review. Br J Cancer 9:1813
15. Smith FM, Reynolds JV, Miller N et al (2006) Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy. Eur J Surg Oncol 1:55-64
16. Knutsen A, Adell GSun XF (2004) Survivin expression is an independent prognostic factor in rectal cancer patients with and without preoperative radiotherapy. Int J Radiat Oncol Biol Phys 1:149-155
17. Adida C, Crotty PL, McGrath J et al (1998) Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Pathol 1:43-49
18. Ambrosini G, Adida Caltieri DC (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 8:917-921
19. Rodel C, Haas J, Groth A et al (2003) Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: Survivin as a radioresistance factor. Int J Radiat Oncol Biol Phys 5:1341-1347
20. Rodel F, Hoffmann J, Grabenbauer GG et al (2002) High survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection. Strahlenther Onkol 8:426-435
21. Kawasaki H, Toyoda M, Shinohara H et al (2001) Expression of survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis. Cancer 11:2026-2032
22. Chen WC, Liu Q, Fu JX et al (2004) Expression of survivin and its significance in colorectal cancer. World J Gastroenterol 19:2886-2889
23. Rodel F, Hoffmann J, Distel L et al (2005) Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res 11:4881-4887
24. Tan HY, Liu J, Wu SM et al (2005) Expression of a novel apoptosis inhibitor-survivin in colorectal carcinoma. World J Gastroenterol 30:4689-4692
25. Terzi C, Canda AE, Sagol O et al (2008) Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy. Int J Colorectal Dis 1:37-45
26. Sobin LH, Wittekind C (2002) TNM classification of malignant tumours, 6th edn. Wiley-Liss, New Jersey
27. Mandard AM, Dalibard F, Mandard JC et al (1994) Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations. Cancer 11:2680-2686
28. Kennedy SM, O'Driscoll L, Purcell R et al (2003) Prognostic importance of survivin in breast cancer. Br J Cancer 7:1077-1083
29. Raouf A, Evoy D, Carton E et al (2001) Spontaneous and inducible apoptosis in oesophageal adenocarcinoma. Br J Cancer 11:1781-1786
30. Lezoche E, Guerrieri M, Paganini AM et al (2005) Long-term results in patients with T2-3 N0 distal rectal cancer undergoing radiotherapy before transanal endoscopic microsurgery. Br J Surg 12:1546-1552
31. Stipa F, Lucandri G, Ferri M et al (2004) Local excision of rectal cancer with transanal endoscopic microsurgery (TEM). Anticancer Res 2C:1167-1172
32. Ruo L, Guillem JG, Minsky BD et al (2002) Preoperative radiation with or without chemotherapy and full-thickness transanal excision for selected T2 and T3 distal rectal cancers. Int J Colorectal Dis 1:54-58
33. Rodel C, Grabenbauer GG, Papadopoulos T et al (2002) Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer. Int J Radiat Oncol Biol Phys 2:294-303
34. Li F, Yang J, Ramnath N et al (2005) Nuclear or cytoplasmic expression of survivin: What is the significance? Int J Cancer 4:509-512
35. Lin LJ, Zheng CQ, Jin Y et al (2003) Expression of survivin protein in human colorectal carcinogenesis. World J Gastroenterol 5:974-977
36. Sarela AI, Scott N, Ramsdale J et al (2001) Immunohistochemical detection of the anti-apoptosis protein, survivin, predicts survival after curative resection of stage II colorectal carcinomas. Ann Surg Oncol 4:305-310
37. Ponnelle T, Chapusot C, Martin L et al (2005) Cellular localisation of survivin: Impact on the prognosis in colorectal cancer. J Cancer Res Clin Oncol 8:504-510
38. Agui T, McConkey DJ, Tanigawa N (2002) Comparative study of various biological parameters, including expression of survivin, between primary and metastatic human colonic adenocarcinomas. Anticancer Res 3:1769-776
39. Mahotka C, Liebmann J, Wenzel M et al (2002) Differential subcellular localization of functionally divergent survivin splice variants. Cell Death Differ 12:1334-1342