Relationship between serum progesterone concentrations and cardiovascular disease, diabetes, and mortality in elderly Swedish men and women: An 8-Year prospective study

Gender Medicine

Volumn 6, Issue 3, 2009, Pages 433-443

  Nilsson, Sven E ^a   Fransson, Eleonor ^a   Brismar, Kerstin ^b  

^a JÖNKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

cardiovascular disease; congestive heart failure; CRP; cystatin; diabetes; elderly; insulin; mortality; progesterone

Indexed keywords

C REACTIVE PROTEIN; CYSTATIN;

AGED; ANGINA PECTORIS; ARTICLE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DIABETES MELLITUS; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLOW UP; HEART ARRHYTHMIA; HEART INFARCTION; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MORTALITY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PREVALENCE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROSPECTIVE STUDY; SEX DIFFERENCE; SWEDEN; THROMBOEMBOLISM; UREA BLOOD LEVEL;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CYSTATINS; DIABETES MELLITUS; ESTRADIOL; FEMALE; HEART FAILURE; HUMANS; LONGITUDINAL STUDIES; MALE; PREVALENCE; PROGESTERONE; PROSPECTIVE STUDIES; RISK FACTORS; SWEDEN; UREA;

EID: 70349999252     PISSN: 15508579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.genm.2009.09.011     Document Type: Article

References (30)

1. Keating N.L., Cleary P.D., Rossi A.S., et al. Use of hormone replacement therapy by postmenopausal women in the United States. Ann Intern Med. 130 (1999) 545-553
2. Thunell L., Stadberg E., Milsom I., and Mattsson L.A. A longitudinal population study of climacteric symptoms and their treatment in a random sample of Swedish women. Climacteric. 7 (2004) 357-365
3. Barrett-Connor E. Postmenopausal estrogen and heart disease. Atherosclerosis. 118 Suppl (1995) S7-S10
4. Hulley S., Grady D., Bush T., et al., the Heart and Estrogen/progestin Replacement Study (HERS) Research Group. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA. 280 (1998) 605-613
5. Rossouw J.E., Anderson G.L., Prentice R.L., et al., the Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA. 288 (2002) 321-333
6. Wolf O.T., Heinrich A.B., Hanstein B., and Kirschbaum C. Estradiol or estradiol/progesterone treatment in older women: No strong effects on cognition. Neurobiol Aging. 26 (2005) 1029-1033
7. Rosenthal A.D., Shu X.O., Jin F., et al. Oral contraceptive use and risk of diabetes among Chinese women. Contraception. 69 (2004) 251-257
8. Kim C., Newton K.M., and Knopp R.H. Gestational diabetes and the incidence of type 2 diabetes: A systematic review. Diabetes Care. 25 (2002) 1862-1868
9. Strauss III J.F. Some new thoughts on the patho-physiology and genetics of polycystic ovary syndrome. Ann N Y Acad Sci. 997 (2003) 42-48
10. Nestler J.E. Role of hyperinsulinemia in the patho-genesis of the polycystic ovary syndrome, and its clinical implications. Semin Reprod Endocrinol. 15 (1997) 111-122
11. Brismar K., and Nilsson S.E. Interrelations and associations of serum levels of steroids and pituitary hormones with markers of insulin resistance, inflammatory activity, and renal function in men and women aged >70 years in an 8-year longitudinal study of opposite sex twins. Gend Med. 6 Suppl 1 (2009) 123-126
12. Gold C.H., Malmberg B., McClearn G.E., et al. Gender and health: A study of older unlike-sex twins. J Gerontol B Psychol Sci Soc Sci. 57 (2002) S168-S176
13. Cederlöf R., and Lorich U. The Swedish Twin Registry. In: Nance W.E., Allen G., and Parisi P. (Eds). Twin Research: Biology and Epidemiology (1978), Alan R. Liss, New York, NY 189-195
14. World Health Organization. ICD-10. International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (1992), World Health Organization, Geneva, Switzerland
15. Simmons S.F., Johansson B., Zarit S.H., et al. Selection bias in samples of older twins? A comparison between octogenarian twins and singletons in Sweden. J Aging Health. 9 (1997) 553-567
16. Nilsson S.E., Johansson B., Berg S., et al. A comparison of diagnosis capture from medical records, self-reports, and drug registrations: A study in individuals 80 years and older. Aging Clin Exp Res. 14 (2002) 178-184
17. Tietz N.W. Clinical Guide to Laboratory Tests. 3rd ed. (1995), WB Saunders, Philadelphia, Pa
18. Nilsson S.E., Evrin P.E., Tryding N., et al. Biochemical values in persons older than 82 years of age: Report from a population-based study of twins. Scand J Clin Lab Invest. 63 (2003) 1-13
19. Stevenson J.C., Proudler A.J., Walton C., and Godsland I.F. HRT mechanisms of action: Carbohydrates. Int J Fertil Menopausal Stud. 39 Suppl 1 (1994) 50-55
20. Sorenson R.L., Brelje T.C., and Roth C. Effects of steroid and lactogenic hormones on islets of Langerhans: A new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy. Endocrinology. 133 (1993) 2227-2234
21. Tchernof A., Després J.P., Dupont A., et al. Relation of steroid hormones to glucose tolerance and plasma insulin levels in men. Importance of visceral adipose tissue. Diabetes Care. 18 (1995) 292-299
22. Picard F., Wanatabe M., Schoonjans K., et al. Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta-cell proliferation. Proc Natl Acad Sci U S A. 99 (2002) 15644-15648
23. Cushman M., Legault C., Barrett-Connor E., et al. Effect of postmenopausal hormones on inflammation-sensitive proteins: The Postmenopausal Estrogen/ Progestin Interventions (PEPI) Study. Circulation. 100 (1999) 717-722
24. Ridker P.M., Hennekens C.H., Rifai N., et al. Hormone replacement therapy and increased plasma concentration of C-reactive protein. Circulation. 100 (1999) 713-716
25. Hu P., Greendale G.A., Palla S.L., et al. The effects of hormone therapy on the markers of inflammation and endothelial function and plasma matrix metalloproteinase-9 level in postmenopausal women: The Postmenopausal Estrogen Progestin Intervention (PEPI) trial. Atherosclerosis. 185 (2006) 347-352
26. Jain S.K., Kannan K., Prouty L., and Jain S.K. Progesterone, but not 17beta-estradiol, increases TNF-alpha secretion in U937 monocytes. Cytokine. 26 (2004) 102-105
27. Crandall C., Palla S., Reboussin B., et al. Cross-sectional association between markers of inflammation and serum sex steroid levels in the Postmenopausal Estrogen/Progestin Interventions trial. J Womens Health (Larchmt). 15 (2006) 14-23
28. Nakamura S., Yoshimura M., Nakayama M., et al. Possible association of heart failure status with synthetic balance between aldosterone and dehy-droepiandrosterone in human heart. Circulation. 110 (2004) 1787-1793
29. Pitt B., Zannad F., Remme W.J., et al., the Randomized Aldactone Evaluation Study Investigators. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 341 (1999) 709-717
30. Jewell C.W., Watson L.E., Mock J., and Dostal D.E. Aldosterone receptor antagonists and cardiovascular disease: Do we need a change of the guard?. Cardiovasc Hematol Agents Med Chem. 4 (2006) 129-153