Gene polymorphisms and risk of adult early-onset ischemic stroke: A meta-analysis

Thrombosis Research

Volumn 124, Issue 5, 2009, Pages 619-624

  Xin, Xiao Yu ^a   Song, Yan Yan ^b   Ma, Jian Fang ^a   Fan, Cai Ni ^a   Ding, Jian Qing ^a   Yang, Guo Yuan ^c   Chen, Sheng Di ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Early onset; Gene polymorphism; Ischemic stroke; Meta analysis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; BLOOD CLOTTING FACTOR 5; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCOPROTEIN; GLYCOPROTEIN IIIA; PROTHROMBIN;

AGE DISTRIBUTION; ARTICLE; CEREBROVASCULAR ACCIDENT; DATA BASE; DNA POLYMORPHISM; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; HUMAN; ONSET AGE; PRIORITY JOURNAL; RISK ASSESSMENT;

ADOLESCENT; ADULT; APOLIPOPROTEINS E; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HOMOCYSTEINE; HUMANS; LIPID METABOLISM; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC; STROKE; YOUNG ADULT;

EID: 70349997042     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2009.07.007     Document Type: Article

References (46)

1. Lopez A.D., Mathers C.D., Ezzati M., Jamison D.T., and Murray C.J. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367 (2006) 1747-1757
2. Hart R.G., and Miller V.T. Cerebral infarction in young adults: a practical aproach. Stroke 14 (1983) 110-114
3. Adams H.P., Butler M.J., Biller J., and Toffol G.J. Nonhemorrhagic cerebral infarction in young adults. Arch Neurol 43 (1986) 793-796
4. Kiely D., Wolf P., Cupples A., Beiser A.S., and Myers R.H. Familial aggregation of stroke-the Framinghan study. Stroke 24 (1993) 1366-1371
5. Brass L.M., Isaacsohn J., Merikangas K.R., and Robinette C.D. A study of twins and stroke. Stroke 23 (1992) 221-223
6. Dichgans M., and Markus H.S. Genetic association studies in stroke: methodological issues and proposed standard criteria. Stroke 36 (2005) 2027-2031
7. Kim R.J., and Becker R.C. Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies. Am Heart J 146 (2003) 948-957
8. Xu X.W., Li J.J., Sheng W.L., and Liu L. Meta-analysis of genetic studies from journals published in China of ischemic stroke in the Han Chinese Population. Cerebrovasc Dis 26 (2008) 48-62
9. Casas J.P., Hingorani A.D., Bautista L.E., and Sharma P. Meta-analysis of genetic studies in ischemic stroke.Thirty-two genes involving approximately 18000 cases and 58000 controls. Arch Neurol 61 (2004) 1652-1662
10. Banerjee I., Gupta V., and Ganesh S. Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis. J Hum Genet 52 (2007) 205-219
11. Thakkinstian A., Bowe S., McEvoy M., Smith W., and Attia J. Association between apolipoprotein E polymorphisms and age-related macular degeneration: a HuGE review and meta-analysis. Am J Epidemiol 164 (2006) 813-822
12. Attia J., Thakkinstian A., and D'Este C. Systematic review of meta-analyses of molecular association studies: methodologic lesson for genetic epidemiology. J Clin Epidemiol 56 (2003) 297-303
13. Zintzaras E., Rodopoulou P., and Sakellaridis N. Variants of the arachidonate 5-lipoxygense-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. Am J Epidemiol 169 (2009) 523-532
14. Cochran W.G. The combination of estimates from different experiments. Biometrics 10 (1954) 101-129
15. Pongrácz E., Andrikovics H., Bernát I.S., and Nagy Z. Connection between genetically determined blood coagulation factors and haemorheology. Clin Hemorheol Microcirc 39 (2008) 333-341
16. Pezzini A., Grassi M., Del Zotto E., Giossi A., Monastero R., Dalla Volta G., et al. Migraine mediates the influence of C677T MTHFR Genotype on ischemic stroke risk with a stroke-subtype effect. Stroke 38 (2007) 3145-3151
17. Martinelli I., Battaglioli T., Burgo I., Di Domenico S., and Mannucci P.M. Oral contraceptive use, thrombophilia and their interaction in young women with ischemic stroke. Haematologica 91 (2006) 844-847
18. Howard T.D., Giles W.H., Wozniak M.A., Malarcher A.M., Lange L.A., and Macko R.F. Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women. Stroke 36 (2005) 1848-1853
19. Pezzini A., Grassi M., Del Zotto E., Archetti S., Spezi R., and Vergani V. Cumulative effect of predisposing genotypes and their interaction with modifiable factors on the risk of ischemic stroke in young adults. Stroke 36 (2005) 533-539
20. Aznar J., Mira Y., Vayá A., Corella D., Ferrando F., Villa P., et al. Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke. Thromb Haemost 91 (2004) 1031-1034
21. Lichy C., Kropp S., Dong-Si T., Genius J., Dolan T., Hampe T., et al. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Stroke 35 (2004) 40-45
22. Rubattu S., Speranza R., Ferrari M., Evangelista A., Beccia M., Stanzione R., et al. A role of TNF-αgene variant on juvenile ischemic stroke: a case-control study. Eur J Neurol 12 (2005) 989-993
23. van Goor M.L., Gómez García E., Brouwers G.J., Leebeek F.W., Koudstaal P.J., and Dippel D.W. PLA1/A2 polymorphism of the platelet glycoprotein receptor IIb/IIIa in young patients with crytogenic TIA or ischemic stroke. Thromb Res 108 (2002) 63-65
24. Gómez Garcia E.B., van Goor M.P., Leebeek F.W., Brouwers G.J., Koudstaal P.J., and Dippel D.W. Elevated prothrombin is a risk factor for cerebral arterial ischemia in young adults. Clin Neurol Neurosurg 104 (2002) 285-288
25. Lopaciuk S., Bykowska K., Kwiecinski H., Mickielewicz A., Czlonkowska A., Mendel T., et al. Factor V Leiden, prothrombin gene G20210A variant, and methylenetetrahydrofolate reductase C677T genotype in young adults with ischemic stroke. Clin Appl Thromb Hemost 7 (2001) 346-350
26. Reiner A.P., Kumar P.N., Schwartz S.M., Longstreth Jr. W.T., Pearce R.M., Rosendaal F.R., et al. Genetic variants of platelet glycoprotein receptors and risk of stroke in young women. Stroke 31 (2000) 1628-1633
27. 1 might be a genetic risk factor for the development of stroke in younger patients. Blood 93 (1999) 3593-3586
28. Carter A.M., Catto A.J., Bamford J.M., and Grant P.J. Platelet GP IIIa PIA and GP Ib variable number tandem repeat polymorphisms and markers of platelet activation in acute stroke. Arterioscler Thromb Vasc Biol 18 (1998) 1124-1131
29. Nabavi D.G., Junker R., Wolff E., Lüdemann P., Doherty C., and Evers S. Prevalence of factor V Leiden mutation in young adults with cerebral ischaemia: a case-control study on 225 patients. J Neurol 245 (1998) 653-658
30. Gao J., Sun Y.F., Li Y.L., Su L.K., and Guo L. Hyperhomocysteine, genetic polymorphism of methylenetetra-hydrofolate reductase in young adults with ischemic stroke. J Zhengzhou Univ Med Sci 43 (2008) 570-573
31. Shi C.N., Kang X.X., Wang Y.J., and Zhou Y.L. The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke. Clin Chim Acta 396 (2008) 7-9
32. Fang L., Wang T.W., Shao Y.S., and Yang H. Association between MTHFRC677T, CBS844ins68 polymorphism and young ischemic stroke. J Jilin Univ Med Ed 33 (2007) 310-313
33. Jiang Z.Q., Liu H., and Zhang G.Z. Relationship between polymorphism of apolipoprotein E gene and atherosclerotic cerebral infarction, hypertensive intracerebral hemorrhage in the youth. J Gannan Med Univ 26 (2006) 331-334
34. A1/A2 polymorphisms and ischemic stroke in young Taiwanese. J Neurol Sci 227 (2004) 1-5
35. Yeh P.S., Lin H.J., Li Y.H., Lin K.C., Cheng T.J., Chang C.Y., et al. Prognosis of young ischemic stroke in Taiwan: impact of prothrombotic genetic polymorphisms. Thromb Haemost 92 (2004) 583-589
36. Li Z.H., Liu W.G., Zhao X.Y., and Chen Y.Q. Risk factor for stroke and ApoE polymorphism in the young and middle-aged. Stroke Nerv Dis 8 (2001) 326-329
37. de Oliveira M.H., André C., Spector N., Luiz R.R., de Castro Souza G., and Gadelha T. 807C/T polymorphism in the platelet glycoprotein Ia gene in young patients with ischemic stroke of undetermined etiology. Blood Coagul Fibrinolysis 18 (2007) 599-602
38. Voetsch B., Jin R.C., Bierl C., Benke K.S., Kenet G., Simioni P., et al. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke 38 (2007) 41-49
39. Slooter A.J., Rosendaal F.R., Tanis B.C., Kemmeren J.M., van der Graaf Y., and Algra A. Prothrombotic conditions, oral contraceptives, and the risk of ischemic stroke. J Thromb Haemost 3 (2005) 1213-1217
40. Austin H., Chimowitz M.I., Hill H.A., Chaturvedi S., Wechsler L.R., Wityk R.J., et al. Cryptogenic stroke in relation to genetic variation in clotting factors and other genetic polymorphisms among young men and women. Stroke 33 (2002) 2762-2769
41. Longstreth Jr. W.T., Rosendaal F.R., Siscovick D.S., Vos H.L., Schwartz S.M., Psaty B.M., et al. Risk of stroke in young women and two prothrombotic mutations:factor V Leiden and prothrombin gene variant (G20210A). Stroke 29 (1998) 577-580
42. Paternoster L., Martínez González N.A., Lewis S., and Sudlow C. Association between Apolipoprotein E genotype and carotid intima-media thickness may suggest a specific effect on large artery atherothrombotic stroke. Stroke 39 (2008) 48-54
43. Ariyaratnam R., Casas J.P., Whittaker J., Smeeth L., Hingorani A.D., and Sharma P. Genetics of ischemic stroke among persons of non-European descent: a meta-analysis of eight genes involving ~ 32500 individuals. Plos Med 4 (2007) 728-736
44. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylene tetrahydrofolate reductase. Nat Genet 10 (1995) 111-113
45. Klerk M., Verhoef P., Clarke R., Blom H.J., Kok F.J., and Schouten E.G. MTHFR studies collaboration group: MTHFR 677C→T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 288 (2002) 2023-2031
46. Ye Z., Liu E.H., Higgins J.P., Keavney B.D., Lowe G.D., Collins R., et al. Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66155 cases and 91307 controls. Lancet 367 (2006) 651-658