Oral contraceptive use, thrombophilia and their interaction in young women with ischemic stroke

Haematologica

Volumn 91, Issue 6, 2006, Pages 844-847

  Martinelli, Ida ^a   Battaglioli, Tullia ^a   Burgo, Ilaria ^a   Di Domenico, Sandro ^a   Mannucci, Pier Mannuccio ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Genetics; Homocysteinemia; Risk factors; Thrombophilia

Indexed keywords

BLOOD CLOTTING FACTOR 5; ORAL CONTRACEPTIVE AGENT; PROTHROMBIN;

ADULT; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; RISK ASSESSMENT; THROMBOPHILIA;

ADULT; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CONTRACEPTIVES, ORAL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FACTOR V; FEMALE; HUMANS; HYPERHOMOCYSTEINEMIA; PROTHROMBIN; RETROSPECTIVE STUDIES; THROMBOPHILIA;

EID: 33745742732     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Martinelli I. Risk factors in venous thromboembolism. Thromb Haemost 2001;86:395-403.
2. Martinelli I, Sacchi E, Landi G, Taioli E, Duca F, Mannucci PM. High risk of cerebral vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives. N Engl J Med 1998;338:1793-7.
3. de Bruijn SFTM, Stam J, Koopman MMW, Vandenbroucke JF. Case-control study of risk of cerebral sinous thrombosis in oral contraceptive users who are carriers of hereditary prothrombotic conditions. The Cerebral Venous Sinous Thrombosis Study Group. Br Med J 1998;316:589-92.
4. Gillum LA, Mamidipudi SK, Johnston SC. Ischemic stroke risk with oral contraceptives. A meta-analysis. JAMA 2000;284:72-8.
5. Kemmeren JM, Tanis BC, van den Bosch MA, Bollen EL, Heimerhorst FM, van der Graaf Y, et al. Risk of arterial thrombosis in relation to oral contraceptives (RATIO) study: oral contraceptives and the risk of ischemic stroke. Stroke 2002;33:1202-8.
6. Lidegaard O, Kreiner S. Contraceptives and cerebral thrombosis: a five-year national case-control study. Contraception 2002;65:197-205.
7. Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutations in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995;332: 912-7.
8. Landi G, Cella E, Martinelli I, Tagliabue L, Mannucci PM, Zerbi D. Arg506Gln factor V mutation and cerebral ischemia in the young. Stroke 1996;27: 1697-8.
9. Martinelli I, Franchi F, Akwan S, Bettini P, Merati G, Mannucci PM. The transition G to A in the 3′-untranslated region of the prothrombin gene is not associated with cerebral ischemia. Blood 1997;90:3806.
10. De Stefano V, Chiusolo P, Paciaroni K, Casorelli I, Rossi E, Molinari M, et al. Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients. Blood 1998;91:3562-5.
11. Aznar J, Mira Y, Vaya A, Corella D, Ferrando F, Villa P, et al. Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke. Thromb Haemost 2004;91:1013-4.
12. Slooter AJC, Rosendaal FR, Tanis BC, Kemmeren JM, Van der Graaf Y, Algra A. Prothrombotic conditions, oral contraceptives, and the risk of ischemic stroke. J Thromb Haemost 2005; 3: 1213-7.
13. Cattaneo M. Hyperhomocysteinemia, atherosclerosis and thrombosis. Thromb Haemost 1999;81:165-76.
14. Madonna P, De Stafano V, Coppola A, Cirillo F, Cerbone AM, Orefice G, et al. Hyperhomocysteinemia and other inherited prothrombotic conditions in young adults with a history of ischemic stroke. Stroke 2002;3: 51-6.
15. WHO Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Ischaemic stroke and combined oral contraceptives: results of an international, multicentre, case-control study. Lancet 1996;348:498-505.
16. Lothar AJ, Heinemann MAL, Spitzer WO, Thorogood M, Guggenmood-Holzmann I, Bruppacher T. Thromboembolic stroke in young women. A European case-control study on oral contraceptives. The Transnational Research Group or Oral Contraceptives and the Health of Young Women. Contraception 1998; 57:29-37.
17. Frezzato M, Tosetto A, Rodeghiero F. Validated questionnaire for the identification of previous personal or familial venous thromboembolism. Am J Epidemiol 1996;143:1257-65.
18. Zighetti ML, Cattaneo M, Falcon CR, Lobardi R, Harari S, Savoritto S, et al. Absence of hyperhomocysteinemia in ten patients with primary pulmonary hypertension. Thromb Res 1997;85: 279-82.
19. Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtypes of acute ischemic stroke. Definition for use in a multicenter clinical trial. The TOAST Investigators. Stroke 1993;24:35-41.
20. Sarti C, Stegmayr B, Tolonen H, Mahonen M, Tuomilehto J, Asplund K. Are changes in mortality from stroke caused by changes in stroke event rates or case fatality? Results from the WHO MONICA Project. Stroke 2003;34:1833-40.