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Volumn 48, Issue 20, 2009, Pages 3661-3664

Silver nanoparticle formation in different sizes induced by peptides identified within split-and-mix libraries

Author keywords

Combinatorial chemistry; Nanostructures; Peptides; Silver; Solid phase synthesis

Indexed keywords

AG NANOPARTICLE; COMBINATORIAL CHEMISTRY; DIFFERENT SIZES; SEM; SILVER NANOPARTICLES; SODIUM ASCORBATE; SOLID-PHASE SYNTHESIS;

EID: 70349974588     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200806265     Document Type: Article
Times cited : (54)

References (50)
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    • For a general review on peptide-directed metal NP formation, see: M. B. Dickerson, K. H. Sandhage, R. R. Naik, Chem. Rev. 2008,108, 4935-4978.
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    • For examples of the generation of AgNPs and Ag nanostructures in general using peptidic scaffolds, see: a A. Mantion, A. G. Guex, A. Foelske, L. Mirolo, K. M. Fromm, M. Painsi, A. Taubert, Soft Matter 2008, 4, 606-617;
    • For examples of the generation of AgNPs and Ag nanostructures in general using peptidic scaffolds, see: a) A. Mantion, A. G. Guex, A. Foelske, L. Mirolo, K. M. Fromm, M. Painsi, A. Taubert, Soft Matter 2008, 4, 606-617;
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    • For the use of phage display libraries, see: a) F. Baneyx, D. T. Schwartz, Curr. Opin. Biotechnol. 2007, 18, 312-317;
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    • For the use of split-and-mix libraries to identify selective intermolecular interactions or catalysts, see: a N. Srinivasan, J. D. Kilburn, Curr. Opin. Chem. Biol. 2004, 8, 305-310;
    • For the use of split-and-mix libraries to identify selective intermolecular interactions or catalysts, see: a) N. Srinivasan, J. D. Kilburn, Curr. Opin. Chem. Biol. 2004, 8, 305-310;
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    • A total of at least five theoretical copies of the library was used per screening in order to ensure the presence of each library member; a K. Burgess, A. I. Liaw, N. Y Wang, J. Med. Chem. 1994, 37, 2985-2987;
    • A total of at least five theoretical copies of the library was used per screening in order to ensure the presence of each library member; a) K. Burgess, A. I. Liaw, N. Y Wang, J. Med. Chem. 1994, 37, 2985-2987;
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    • As the beads were not continuously agitated upon irradiation with light, several of the beads are colored on only one half
    • As the beads were not continuously agitated upon irradiation with light, several of the beads are colored on only one half.
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    • In control experiments with a tripeptide library of the general structure Ac-AA3-AA2-AA1-resin with no linkers between the amino acids, AgNP formation was not observed under identical conditions. This experiment further supports the importance of the rigid linker. For the importance of turn-inducing linkers in peptide binding to metal ions other than Ag+, see: M. B. Francis, N. S. Finney, E. N. Jacobsen, J. Am. Chem. Soc. 1996, 118, 8983-8984.
    • In control experiments with a tripeptide library of the general structure Ac-AA3-AA2-AA1-resin with no linkers between the amino acids, AgNP formation was not observed under identical conditions. This experiment further supports the importance of the rigid linker. For the importance of turn-inducing linkers in peptide binding to metal ions other than Ag+, see: M. B. Francis, N. S. Finney, E. N. Jacobsen, J. Am. Chem. Soc. 1996, 118, 8983-8984.
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    • All possible diastereoisomers of peptides 2 a and 3 a were examined and showed essentially the same results, which demonstrates that the absolute configuration of the amino acids is of minor importance for activity
    • All possible diastereoisomers of peptides 2 a and 3 a were examined and showed essentially the same results, which demonstrates that the absolute configuration of the amino acids is of minor importance for activity.
  • 49
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    • Negative control experiments with peptides that were not hits in the combinatorial assay (e.g, Ac-Tyr-Gly-Tyr-TG) did not form AgNPs under identical conditions
    • Negative control experiments with peptides that were not hits in the combinatorial assay (e.g., Ac-Tyr-Gly-Tyr-TG) did not form AgNPs under identical conditions.
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    • For details on the Ag+ ion uptake studies see the Supporting Information
    • M. Conza, H. Wennemers, Chem. Commun. 2003, 866-867. For details on the Ag+ ion uptake studies see the Supporting Information.
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    • Conza, M.1    Wennemers, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.