Intravenous ketamine and local bupivacaine infiltration are effective as part of a multimodal regime for reducing post-tonsillectomy pain

Medical Science Monitor

Volumn 15, Issue 10, 2009, Pages

  Inanoglu, Kerem ^a,b   Akkurt, B Cagla Ozbakis ^a   Turhanoglu, Selim ^a   Okuyucu, Semsettin ^a   Akoglu, Ertap ^a  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

^b MKU Arastirma Hastanesi   (Turkey)

Author keywords

Bupivacaine; Children; Ketamine; Pain; Tonsillectomy

Indexed keywords

BUPIVACAINE; KETAMINE; PLACEBO;

ANALGESIA; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; POSTOPERATIVE PAIN; POSTTONSILLECTOMY PAIN; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCORING SYSTEM; TONSILLECTOMY;

ADOLESCENT; ANALGESICS; BUPIVACAINE; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; DEMOGRAPHY; HUMANS; INJECTIONS, INTRAVENOUS; KETAMINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; TONSILLECTOMY;

EID: 70349972805     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Dal D, Celebi N, Elvan EG et al: The efficacy of intravenous or peritonsillar infiltration of ketamine for postoperative pain relief in children following adenotonsillectomy. Paediatr Anaesth, 2007; 17: 263-269 (Pubitemid 46181389)
2. O'Flaherty JE, Lin CX: Does ketamine or magnesium affect post-tonsillectomy pain in children? Paediatr Anaesth, 2003; 13: 413-421
3. Akoglu E, Akkurt BC, Inanoglu K et al: Ropivacaine compared to bupivacaine for post-tonsillectomy pain relief in children: a randomized controlled study. Int J Pediatr Otorhinolaryngol, 2006; 70: 1169-1173 (Pubitemid 43792321)
4. Kelly PE: Painless tonsillectomy. Curr Opin Otolaryngol Head Neck Surg, 2006; 14: 369-374
5. Erhan OL, Goksu H, Alpay C, Bestas A: Ketamine in post-tonsillectomy pain. Int J Pediatr Otorhinolaryngol, 2007; 71: 735-739
6. Jebeles JA, Reilly JS, Gutierrez JF et al: The effect of preincisional infiltration of tonsils with bupivacaine on the pain following tonsillectomy under general anesthesia. Pain, 1991; 47: 305-308
7. Unal Y, Pampal K, Korkmaz S et al: Comparison of bupivacaine and ropivacaine on postoperative pain after tonsillectomy in paediatric patients. Int J Pediatr Otorhinolaryngol, 2007; 71: 83-87 (Pubitemid 44959081)
8. Da Conceicao MJ, Bruggemann Da Conceicao D, Carneiro Leao C: Effect of an intravenous single dose of ketamine on postoperative pain in tonsillectomy patients. Paediatr Anaesth 2006; 16: 962-967 (Pubitemid 44215160)
9. Splinter WM, Semelhago LC, Chou S: The reliability and validity of a modified CHEOPS pain score, Anesth. Analg, 1994; 78: 413
10. 10, Molliex S, Haond P, Baylot D et al: Effect of pre- vs postoperative tonsillar infiltration with local anesthetics on postoperative pain after tonsillectomy. Acta Anaesthesiol Scand, 1996; 40: 1210-1215 (Pubitemid 26411387)
11. Goldsher M, Podoshin L, Fradis M et al: Effects of peritonsillar infiltration on post-tonsillectomy pain. A double-blind study. Ann Otol Rhinol Laryngol, 1996; 105: 868-870
12. Nikandish R, Maghsoodi B, Khademi S et al: Peritonsillar infiltration with bupivacaine and pethidine for relief of post-tonsillectomy pain: a randomised double-blind study. Anaesthesia, 2008; 63: 20-25 (Pubitemid 350233212)
13. Woolf CJ, Thompson SW: The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain, 1991; 44: 293-299
14. Woolf CJ, Chong MS: Preemptive analgesia-treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg, 1993; 77: 362-379
15. Aydin ON, Ugur B, Ozgun S et al: Pain prevention with intraoperative ketamine in children undergoing tonsillectomy or tonsillectomy and adenotomy. J Clin Anesth, 2007; 19: 115-119 (Pubitemid 46437302)
16. Bell RF, Dahl JB, Moore RA, Kalso E: Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review). Acta Anaesthesiol Scand, 2005; 49: 1405-1428
17. Kehlet H, Dahl JB: The value of "multimodal" or "balanced analgesia" in postoperative pain treatment. Anesth Analg, 1993; 77: 1048-1056
18. Sumpelmann R, Munte S: Postoperative analgesia in infants and children. Curr Opin Anaesthesiol, 2003; 16: 309-313
19. Elia N, Tramer MR: Ketamine and postoperative pain-a quantitative systematic review of randomized trials. Pain, 2005; 113: 61-70 (Pubitemid 40044753)
20. Aspinall RL, Mayor A: A prospective randomized controlled study of the efficacy of ketamine for postoperative pain relief in children after adenotonsillectomy. Paediatr Anaesth, 2001; 11: 333-336
21. Umuroglu T, Eti Z, Ciftci H, Yilmaz Gogus F: Analgesia for adenotonsillectomy in children: a comparison of morphine, ketamine and tramadol. Paediatr Anaesth, 2004; 14: 568-573 (Pubitemid 38869924)
22. Abu-Shahwan I: Ketamine does not reduce postoperative morphine consumption after tonsillectomy in children. Clin J Pain, 2008; 24: 395-398
23. Shah RK, Preciado DA: Re: the efficacy of intravenous or peritonsillar infiltration of ketamine for postoperative pain relief in children following adenotonsillectomy. Paediatr Anaesth, 2007; 17: 1114-1115 (Pubitemid 47481129)
24. Piper S, Beschmann R, Mengistu A et al: Postoperative analgosedation with S(+)-ketamine decreases the incidences of postanesthetic shivering and nausea and vomiting after cardiac surgery. Med Sci Monit, 2008; 14(12): PI159-65