Effect of Laggera alata on hepatocyte damage induced by carbon tetrachloride in vitro and in vivo

Journal of Ethnopharmacology

Volumn 126, Issue 1, 2009, Pages 50-56

  Wu, Yi Hang ^a,b   Zhang, Xiao Meng ^a   Hu, Ming Hui ^b   Wu, Xiu Mei ^c   Zhao, Yu ^b  

^a CHINA JILIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c Zhejiang Hisun Naturelite Pharmaceutical R and D Co Ltd   (China)

Author keywords

Carbon tetrachloride; Dicaffeoylquinic acids; Hepatoprotective; Laggera alata

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CYNARINE; HYDROXYPROLINE; LAGGERA ALATA EXTRACT; PHENOL DERIVATIVE; PLANT EXTRACT; PROTEIN; SIALIC ACID; SILIBININ; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL VIABILITY; CHEMICAL COMPOSITION; CHINESE MEDICINE; CONTROLLED STUDY; DRUG SYNTHESIS; HEPATITIS; HERBAL MEDICINE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LAGGERA ALATA; LIVER CELL CULTURE; LIVER CELL DAMAGE; LIVER INJURY; LIVER PROTECTION; MALE; MEDICINAL PLANT; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; TRADITIONAL MEDICINE;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; ASTERACEAE; BLOOD PROTEINS; CARBON TETRACHLORIDE; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; HEPATOCYTES; HYDROXYPROLINE; MALE; MICE; MICE, INBRED ICR; N-ACETYLNEURAMINIC ACID; PHYTOTHERAPY; PLANT EXTRACTS; QUINIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN;

LAGGERA ALATA; MUS; RATTUS;

EID: 70349966222     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.08.030     Document Type: Article

References (31)

1. Anil Kumar P.R., Menon B., Anil Kumar T.V., and Kumari T.V. Culture of neonatal rat liver cells: a preliminary observation. Trends of Biomaterials & Artificial Organs 16 (2002) 34-37
2. 4 rat liver slices. Toxicology and Applied Pharmacology 112 (1992) 81-86
3. Bedda S., Laurent A., Conti F., Chereau C., Tran A., Tran-Van Nhieu J., Jaffray P., Soubrane O., Goulvestre C., Calmus Y., Weill B., and Batteux F. Mangafodipir prevents liver injury induced by acetaminophen in the mouse. Journal of Hepatology 39 (2003) 765-772
4. Bohlmann F., Wallmeyer M., Jakupovic J., Gerke T., King R.M., and Robinson H. Cuauthemone sesquiterpenoids from Blumea alata. Phytochemistry 24 (1985) 505-509
5. Brent J.A., and Rumack B.H. Role of free radicals in toxic hepatic injury II. Clinical Toxicology 31 (1993) 173-196
6. Clawson G.A. Mechanisms of carbon tetrachloride hepatotoxicity. Pathology and Immunopathology Research 8 (1989) 104-112
7. Farber E., Liang H., and Shinozuka H. Dissociation of effects on protein synthesis and ribosomes from membrane changes induced by carbon tetrachloride. American Journal of Pathology 64 (1971) 601-617
8. Fehèr J., and Prònai L. The role of free radical scavengers in gastrointestinal diseases. Orvosi Hetilap 134 (1993) 693-696
9. Fraschini F., Demartini G., and Esposti D. Pharmacology of silymarin. Clinical Drug Investigation 22 (2002) 51-65
10. Gongora L., Manez S., Giner R.M., Recio Mdel C., Schinella G., and Rios J.L. Inhibition of xanthine oxidase by phenolic conjugates of methylated quinic acid. Planta Medica 69 (2003) 396-401
11. Gravela E., Albano E., Dianzani M.U., Poli G., and Slater T.F. Effects of carbon tetrachloride on isolated rat hepatocytes: inhibition of protein and lipoprotein secretion. Biochemical Journal 178 (1979) 509-512
12. Jiangsu New Medical College. A Dictionary of Traditional Chinese Drugs. 1st ed. (1977), Shanghai People's Press, Shanghai
13. Kimura Y., Okuda H., Okuda T., Hatano T., and Arichi S. Studies on the activities of tannins and related compounds. X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes. Journal of Natural Products 50 (1987) 392-399
14. Koop C.E. The future of medicine. Science 295 (2002) 233-1233
15. Maruta Y., Kawabata J., and Niki R. Antioxidative caffeoylquinic acid derivatives in the roots of Burdock (Arctium lappa L.). Journal of Agricultural and Food Chemistry 43 (1995) 2592-2595
16. Mcdougall B., King P.J., Wu B.W., Hostomsky Z., Reinecke M.G., and Robinson J.W.E. Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase. Antimicrobial Agents and Chemotherapy 42 (1998) 140-146
17. Okuyama H., Nakamura H., Shimahara Y., Araya S., Kawada N., Yamaoka Y., and Yodoi J. Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice. Hepatology 37 (2003) 1015-1025
18. Ooi Linda S.M., Wang H., He Z.D., and Ooi Vincent E.C. Antiviral activities of purified compounds from Youngia japonica (L.) DC (Asteraceae, Compositae). Journal of Ethnopharmacology 106 (2006) 187-191
19. Park E.J., Zhao Y.Z., Kim Y.C., and Sohn D.H. Protective effect of (S)-bakuchiol from psoralea corylifolia on rat liver injury in vitro and in vivo. Planta Medica 71 (2005) 508-513
20. Peluso G., De Feo V., De Simone F., Bresciano E., and Vuotto M.L. Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production. Journal of Natural Products 58 (1995) 639-646
21. Raharivelomanana P., Bianchini J.P., Ramanoelina R.P., Rasoarhona J.R.E., Faure R., and Cambon A. Eudesmane sesquiterpenes from Laggera alata. Phytochemistry 47 (1998) 1085-1088
22. 4-induced injury in prinmry cultured rat hepatocytes. Pharmaceutical Journal of Chinese People's Liberation Army 20 (2004) 81-84
23. Wang Z.Q., Porreca F., Cuzzocrea S., Galen K., Lightfoot R., Masini E., Muscoli C., Mollace V., Ndengele M., Ischiropoulos H., and Salvemini D. A newly identified role for superoxide in inflammatory pain. Journal of Pharmacology and Experimental Therapeutics 309 (2004) 869-878
24. 4 in hepatic microsomes and reconstituted monooxygenase systems and its relationship to lipid peroxidation. Molecular Pharmacology 18 (1980) 553-558
25. Wu Y.H., Zhou C.X., Song L.Y., Li X.P., Shi S.Y., Mo J.X., Chen H.Y., Bai H., Wu X.M., Zhao J., Zhang R.P., Hao X.J., Sun H.D., and Zhao Y. Effect of total phenolics from Laggera alata on acute and chronic inflammation models. Journal of Ethnopharmacology 108 (2006) 243-250
26. Wu Y.H., Wang F., Zheng Q.X., Lu L.X., Yao H.T., Zhou C.X., Wu X.M., and Zhao Y. Hepatoprotective effect of total flavonoids from Laggera alata against carbon tetrachloride-induced injury in primary cultured neonatal rat hepatocytes and in rats with hepatic damage. Journal of Biomedical Science 13 (2006) 569-578
27. Yagi K. Lipid peroxidation of human diseases. Chemistry and Physics of Lipids 45 (1987) 3337-3351
28. Zheng Q.X., Xu Z.J., Sun X.F., Gueritte F., Cesario M., Cheng C.H.K., Sun H.D., and Zhao Y. New eudesmane and eremophilane derivatives from Laggera alata. Chinese Chemical Letters 14 (2003) 393-396
29. Zheng Q.X., Xu Z.J., Sun X.F., Gueritte F., Cesario M., Sun H.D., Cheng C.H.K., Hao X.J., and Zhao Y. Eudesmane derivatives and other sesquiterpenes from Laggera alata. Journal of Natural Products 66 (2003) 1078-1081
30. Zheng Q.X., Xu Z.J., Sun X.F., Wei Y., Sun H.D., Cheng C.H.K., and Zhao Y. Eudesmane and megastigmane glucosides from Laggera alata. Phytochemistry 23 (2003) 835-839
31. Zhu Y.Z., Huang S.H., Tan B.K.H., Sun J., Whiteman M., and Zhu Y.C. Antioxidants in Chinese herbal medicines: a biochemical perspective. Natural Product Reports 21 (2004) 478-489