New eudesmane and eremophilane derivatives from Laggera alata

Chinese Chemical Letters

Volumn 14, Issue 4, 2003, Pages 393-396

  Zheng, Qun Xiong ^a,c   Xu, Zhao Jun ^a   Sun, Xian Feng ^b   Guéritte, Françoise ^d   Cesario, Michele ^d   Cheng, Christopher H K ^e   Sun, Han Dong ^b   Zhao, Yu ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b KUNMING INSTITUTE OF BOTANY   (China)

^c Hangzhou Institute of Commerce   (China)

^d CNRS   (France)

^e CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cytotoxicity; Eremophilanoid; Eudesmanoid; Laggera alata; Sesquiterpene; X ray diffraction

Indexed keywords

3,5,11(13) TRIENEUDESMA 12 OIC ACID; ANTINEOPLASTIC AGENT; EREMOPHILANOID; LAGGERA ALATA EXTRACT; PLANT EXTRACT; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LAGGERA ALATA; MEDICINAL PLANT; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

EID: 0037906444     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

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7. 1H-NMR spectral data of compounds 1-3. (1): 5.94 (br s, 1H, H-1); 2.34 m, H-3; 2.40 m, H-3'; 2.36 m, H-4; 2.41 m, H-6α; 1.98 m, H-6β; 2.63 (dddd 1H J=11.0, 11.0, 4.5, 4.5Hz, H-7α); 2.00 m, H-8; 2.76 (dddd 1H J=13.5, 11.0, 11.0, 4.5Hz, H-8'); 1.70 (ddd 1H J=13.5, 11.0, 4.5Hz, H-9α); 1.92 (ddd 1H J=13.5, 4.5, 4.5Hz, H-9β); 6.26 (br s, 1H H-13); 5.70 (br s, 1H H-13'); 1.16 s, H-14; 1.05 d (6.0), H-15. (2): 1.60 m, H-1α; 2.05 m, H-1β; 2.06 ddd (12.5, 4.5, 4.5), H-2α; 2.64 ddd (12.5, 11.0, 4.5), H-2β; 5.56 br s, H-3; 5.39 br s, H-6; 3.42 ddd (10.0, 7.5, 3.0), H-7α; 1.44 m, H-8α; 1.40 m, H-8β; 1.54 m, H-9α; 1.56 m, H-9β; 6.34 br s, H-13; 5.70 br s, H-13'; 1.00 s, H-14; 1.79 s, H-15. (3): 1.02 ddd (13.5, 4.8, 4.8), H-1α; 1.76 ddd (13.5, 11.0, 4.8), H-1β; 1.90 (dddd 1H J=13.5, 12.0, 7.0, 4.5Hz, H-2α); 1.68 (dddd 1H J=13.5, 7.0, 4.5, 4.5Hz, H-2β); 1.38 d(dd 1H J=13.5, 6.8, 4.5Hz); 2.68 (ddd 1H J=13.5, 12.0, 6.8Hz, H-3β); 2.06 (dd 1H J=13.5, 4.5Hz, H-6α); 1.48 (dd J=13.5, 12.0Hz, H-6β); 3.49 (dddd 1H J=12.0, 12.0, 4.5, 4.5Hz, H-7α); 1.18 m, H-8α; 1.72 m, H-8β; 1.70 (ddd 1H J=13.2, 9.8, 3.5Hz, H-9α); 1.28 (ddd 1H, J=13.2, 3.5, 3.0Hz, H-9β); 6.10 (br s, H-13); 5.56 (br s, H-13'); 0.99 s, H-14; 1.26 s, H-15.