Hepatoprotective effects of citric acid and aspartame on carbon tetrachloride-induced hepatic damage in rats

EXCLI Journal

Volumn 8, Issue , 2009, Pages 41-49

  Abdel Salam, Omar M E ^a   Sleem, Amany A ^a   Shaffie, Nermeen M ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Acute hepatic injury; Aspartame; Carbon tetrachloride; Citric acid; Rat; Silymarin

Indexed keywords

EID: 70349921881     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Abdel-Salam OME, Debreceni A, MózsikGy, Szolcsányi J. Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents. J Physiol (Paris) 1999;93:443-54.
2. Abdel-Salam OME, Baiuomy AR. Citric acid strongly inhibits visceral pain response in mice. EXCLI J 2008;7:93-103.
3. Abdel-Salam OME, Sleem AA, Hassan NS, Sharaf HA, Mózsik Gy. Capsaicin amelio-rates hepatic injury caused by carbon tetra-chloride in the rat. J Pharmacol Toxicol 2006;1:147-56.
4. Abdel Salam OME, Nofal SM, El-Shenawy SM, Shaffie NM. Effect of piperine on liver damage and bone changes caused by bile duct ligation in rats: Internet J Pharmacol 2008;5(2).
5. Barnett EM, Evans GD, Sun N, Perlman S, Cassell MD. Anterograde tracing of tri-geminal afferent pathways from the murine tooth pulp to cortex using herpes simplex virus type 1. J Neurosci 1995;15:2972-84.
6. Belfield A, Goldberg DM. Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine. Enzyme 1971;12:561-73.
7. Beckman ME, Whitehead MC. Intrame-dullary connections of the rostral nucleus of the solitary tract in the hamster. Brain Res 1991;557:265-79.
8. Bjarnason I, Smethurst P, Macpherson A, Walker F, McElnay JC, Passmore AP, Menzies IS. Glucose and citrate reduce the permeability changes caused by indometha-cin in humans. Gastroenterology 1992;102: 1546-50.
9. Coulombe RA Jr, Sharma RP. Neurobio-chemical alterations induced by the artifi-cial sweetener aspartame (NutraSweet). Toxicol Appl Pharmacol 1986;83:79-85.
10. Crowley LV. The Reitman-Frankel colori-metric transaminase procedure in suspected myocardial infarction. Clin Chem 1967;13: 482-7.
11. Dailey JW, Lasley SM, Burger RL, Betten-dorf AF, Mishra PK, Jobe PC. Amino acids, monoamines and audiogenic seizures in genetically epilepsy-prone rats: effects of aspartame. Epilepsy Res 1991;8:122-33.
12. Dessirier JM, O'Mahony M, Iodi-Carstens M, Carstens E. Sensory properties of citric acid: psychophysical evidence for sensitization, self-desensitization, cross-desensitiza-tion and cross-stimulus-induced recovery following capsaicin. Chem Sens 2000;25: 769-80.
13. Fegan J, Khan R, Poindexter J, Pak CY. Gastrointestinal citrate absorption in nephrolithiasis. J Urol 1992;147: 1212-4.
14. Fox AJ, Barnes PJ, Urban L, Dray A. An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J Physiol (Lond.) 1993;469:21-35.
15. Fox AJ, Urban L, Barnes PJ, Dray A. Ef-fects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig. Neuroscience 1995;67:741-52.
16. Geppetti P, Tramontana M, Del Bianco E, Fusco BM. Capsaicin-desensitization to the human nasal mucosa selectively reduces pain evoked by citric acid. Br J Clin Phar-macol 1993;35:178-83.
17. nd ed. (pp 538 ff.). New York, Basel: Marcel Dekker, Inc., 2002.
18. Gilmore MM, Green BG. Sensory irritation and taste produced by NaCl and citric acid: effects of capsaicin desensitization. Chem Sens 1993;18:257-72.
19. Goehler LE, Sternini C. Calcitonin gene-related peptide innervation of the rat hepatobiliary system. Peptides 1996;17:209-17.
20. Grigor JMV, Johnson WS, Salminen S. Food additives for special dietary purposes. In: Branen AL, Davidson PM, Salminen S, Thorngate III JH (eds). Food additives. 2nd ed. (pp 341 ff.). New York, Basel: Marcel Dekker, Inc., 2002.
21. Grundy D. Neuroanatomy of visceral no-ciception: vagal and splanchnic afferent. Gut 2002;51(Suppl 1):i2-i5.
22. Hanamori T, Ishiko N. Cardiovascular re-sponses to gustatory and mechanical stimulation of the nasopharynx in rats. Brain Res 1993;619: 214-22.
23. Hertelendy ZI, Mendenhall CL, Rouster SD, Marshall L, Weesner R. Biochemical and clinical effects of aspartame in patients with chronic, stable alcoholic liver disease. Am J Gastroenterol 1993;88:737-43.
24. Holzer P, Painsipp E, Schuligoi S. Differen-tial effects of intragastric acid and capsaicin on gastric emptying and afferent input to the rat spinal cord and brainstem. BMC Neurosci 2005;6:60.
25. Horio T. Effect of various taste stimuli on heart rate in humans. Chem Sens 2000;25: 149-53.
26. Hunt SP, Pini A, Evan G. Induction of c-fos-like protein in spinal cord neurons fol-lowing sensory stimulation. Nature 1987; 328:632-3.
27. Kramer L, Bauer E, Joukhadar C, Strobl W, Gendo A, Madl C, Gangl A. Citrate phar-macokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients. Crit Care Med 2003; 31:2450-5.
28. Liu L, Simon SA. Similarities and differ-ences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells. J Neurophysiol 1996;76: 1858-69.
29. Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pariza MW, Spencer PS, Waddell WJ, Walker R, Wil-liams GM. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol 2007;37:629-727.
30. Paget GE, Barnes JM. Toxicity tests. In: Laurence DR, Bacharach AL (ed.) Evaluation of drug activities. Pharmacometrics (p 161). London: Academic Press, 1964.
31. Roper SD. Signal transduction and informa-tion processing in mammalian taste buds. Pfluegers Arch 2007;454:759-76.
32. Simons CT, Boucher Y, Carstens E. Sup-pression of central taste transmission by oral capsaicin. J Neurosci 2003;23:978-85.
33. Stephanie A, Mackey BS, Cheston M, Ber-lin JR. Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenyl-ketonuric patients. Clin Pediatr 1992;31: 394-9.
34. Streefland C, Jansen K. Intramedullary jections of the rostral nucleus of the solitary tract in the rat: gustatory influences on autonomic output. Chem Sens 1999;24: 655-64.
35. Streefland C, Farkas E, Maes FW, Bohus B. C-fos expression in the brainstem after voluntary ingestion of sucrose in the rat. Neurobiology 1996;4:85-102.
36. Szolcsányi J. Tetrodotoxin-resistant non-cholinergic neurogenic contraction evoked by capsaicinoids and piperine on the guinea-pig trachea. Neurosci Lett 1983;42: 83-8.
37. Szolcsányi J, Barthó L. Capsaicin-sensitive afferents and their role in gastroprotection: an update. J Physiol (Paris) 2001;95:181-8.
38. Taylor GA, Moore PB, Ferrier IN, Tyrer SP, Edwardson JA. Gastrointestinal absorption of aluminium and citrate in man. J Inorg Biochem 1998;69:165-9.
39. Tonosaki K, Hori Y, Shimizu Y, Tonosaki K. Relationships between insulin release and taste. Biomed Res 2007;28:79-83.
40. Travers SP. Quinine and citric acid elicit distinctive Fos-like immunoreactivity in the rat nucleus of the solitary tract. Am J Physiol 2002;282:R1798-R1810.
41. Whitehead MC, Frank ME. Anatomy of the gustatory system in the hamster: central projections of the chorda tympani and the lingual nerve. J Comp Neurol 1983;220: 378-95.
42. Yonemura K, Takei M, Kunitake T, Ishiko N. The ability of gustatory stimuli to modify the cardiac sympathetic and vagus nerve activities. Neurosci Lett 1989;97:85-90.