Activity and gene expression profile of certain antioxidant enzymes in different organs of rats after subacute cyanide exposure: Effect of alpha-ketoglutarate

Drug and Chemical Toxicology

Volumn 32, Issue 3, 2009, Pages 268-276

  Hariharakrishnan, Janardhanan ^a   Anand, Tamatam ^a   Satpute, Ravindra M ^a   Jayaraj, Ravindran ^a   Prasad, G B K S ^b   Bhattacharya, Rahul ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

^b JIWAJI UNIVERSITY   (India)

Author keywords

Alpha ketoglutarate; Antioxidant enzymes; Cyanide; Gene expression; HSP 70; Oxidative stress

Indexed keywords

2 OXOGLUTARIC ACID; CATALASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HEAT SHOCK PROTEIN 70; MALONALDEHYDE; POTASSIUM CYANIDE; SUPEROXIDE DISMUTASE; ALPHA-KETOGLUTARIC ACID; ENZYME INHIBITOR; GLUTATHIONE; OXIDOREDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN; CONTROLLED STUDY; CYANIDE POISONING; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION PROFILING; KIDNEY; LIVER; NONHUMAN; OXIDATIVE STRESS; RAT; ANIMAL; CONVALESCENCE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LIPID PEROXIDATION; METABOLISM; TREATMENT WITHDRAWAL; WISTAR RAT;

RATTUS;

ANIMALS; BRAIN; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; HSP70 HEAT-SHOCK PROTEINS; KETOGLUTARIC ACIDS; KIDNEY; LIPID PEROXIDATION; LIVER; MALONDIALDEHYDE; OXIDATIVE STRESS; OXIDOREDUCTASES; POTASSIUM CYANIDE; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; WITHHOLDING TREATMENT;

EID: 70349911955     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540902882218     Document Type: Article

References (42)

1. Adewusi, S.R.A., Akindahunsi, A.A. (1994). Cassava processing, consumption, and cyanide toxicity. J Toxicol Environ Health 43:13-23.
2. Allen, R.G., Tresini, M. (2000). Oxidative stress and gene regulation. Free Rad Biol Med 28:63-499.
3. Andrae, U., Singh, J., Zeigler-Skylakakis, K. (1985). Pyruvate and related alpha-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity. Toxicol Lett 28:93-98.
4. Ardelt, B.K., Borowitz, J.L., Isom, G.E. (1989). Brain lipid peroxidation and antioxidant protectant mechanism following acute cyanide intoxication. Toxicology 56:147-154.
5. Ardelt, B.K., Borowitz, J.L., Maduh, E.U., Swain, S.L., Isom, G.E. (1994). Cyanide-induced lipid peroxidation in different organs: subcellular distribution and hydroperoxide generation in neuronal cells. Toxicology 89:127-137.
6. Ballantyne, B. (1987). Toxicology of cyanides. In: Ballantyne, B., Marrs, T.C. (ED.), Clinical and Experimental Toxicology of Cyanides. Bristol, UK: Wright Publishers.
7. Baskin, S.I., Horowitz, A.M., Nealley, E.W. (1992). The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning. J Clin Pharmacol 32:368-375.
8. Baskin, S.I., Petrikovics, I., Kurche, J.S., Nicholson, J.D., Logue, B.A., Maliner, B.I., et al. (2004). Insights on cyanide toxicity and methods of treatment. In: Flora, S.J.S., Romano, J.S., Baskin, S.I., Sekhar, K. (Eds.), Pharmacological Perspectives of Toxic Chemicals and Their Antidotes (pp 105-146). New Delhi, India: Narosa.
9. Bhattacharya, R. (2004). Alpha-ketoglutarate: a promising antidote to cyanide poisoning. In: Flora, S.J.S., Romano, J.S., Baskin, S.I., Sekhar, K. (Eds.), Pharmacological Perspectives of Toxic Chemicals and Their Antidotes (pp 411-430). New Delhi, India: Narosa.
10. Bhattacharya, R., Lakshmana Rao, P.V., Vijayaraghavan, R. (2002). In vitro and in vivo attenuation of experimental cyanide poisoning by alpha-ketoglutarate. Toxicol Lett 128:185-195.
11. Bhattacharya, R., Vijayaraghavan, R. (2002). Promising role of α-ketoglutarate in protecting against the lethal effects of cyanide. Hum Exp Toxicol 21:297-303.
12. Blanc, P., Hogan, M., Malin, K., Hryhorezuk, D., Hessel, S., Bernard, B. (1985). Cyanide intoxication among silver reclaiming workers. J Am Med Ass 253:367-371.
13. Crampton, R.F., Gaunt, I.F., Harris, R., Knowles, J.F., Langman, M.J., Linell, J.C., et al. (1979). Effects of low cobalamine diet and chronic cyanide toxicity in baboons. Toxicology 12:221-234
14. Cynober, L.A. (1999). The use of α-ketoglutarate salts in clinical nutrition and metabolic care. Clin Nutr Metab Care 2:33-37.
15. Ding, W.X., Ong, C.N. (2003). Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity. FEMS Microbiol Lett 220:1-7.
16. Dulaney, M.D., Jr., Brumley, M., Willis, J.T., Hume, A.S. (1991). Protection against cyanide toxicity by oral alpha-ketoglutaric acid. Vet Hum Toxicol 33:571-575.
17. Eghbal, M.A., Pennefather, P.S., O'Brien, P.J. (2004). H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarization. Toxicology 203:69-76.
18. El Ghawabi, S.H., Gaafar, M.A., El-Saharti, A.A., Soller, H.M., Kamelia, K., Fares, R. (1975). Chronic cyanide exposure: a clinical, radioisotope, and laboratory study. Br J Ind Med 32:215-219.
19. Foulds, W.S., Chisholm, J.A., Bronte-Stewart, J. (1969). Vitamin B12 absorption in tobacco amblyopia. Br J Opthalmol 53:393-397.
20. Hall, A.H., Kulig, K.W., Rumack, B.H. (1989). Suspected cyanide poisoning in smoke inhalation: complications of sodium nitrite therapy. J Toxicol Clin Exp 9:3-9
21. Halliwell, B., Gutteridge, J.M. (1989). Free Radicals in Biology and Medicine, 2nd ed. Oxford, UK: Clarenderon Press.
22. Hissin, P.J., Hilf, R. (1976). A fluorimetric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214-226.
23. Jackson, L.C. (1988). Behavioural effects of chronic sublethal dietary cyanide in an animal model: implications for humans consuming cassava (Manihot esculenta). Hum Biol 60:597-614.
24. Kamalu, B.P. (1993). Pathological changes in growing dog fed on a balanced cassava (Manihot esculenta Crantz) diet. Br J Nutr 69: 921-934.
25. Kiang, J.G., Warke, V.G., Tsokos, G.C. (2003). NaCN-induced chemical hypoxia is associated with altered gene expression. Mol Cell Biochem 254:211-216.
26. Lowry, O.H., Rosenberg, N.J., Farr, A.L., Randall, R.J. (1951). Protein measurement with the Folin-phenol reagent. J Biol Chem 193:265-275.
27. Mates, J.M. (2000). Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153:83-104.
28. Norris, J.C., Utley, W.A., Hume, A.S. (1990). Mechanism of antagonizing cyanide induced lethality by alpha-ketoglutarate. Toxicology 64:275-283.
29. Ohkawa, H., Ohnishi, N., Yagi, K. (1979). Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358.
30. Okolie, N.P., Osagie, A.U. (1999). Liver and kidney lesions and associated enzyme changes induced in rabbits by chronic cyanide exposure. Food Chem Toxicol 37:745-750.
31. Osuntukon, B.O. (1980). A degenerative neuropathy with blindness and chronic cyanide intoxication of dietary origin. The evidence in Nigerians. In: Smith, R.L., Bababunmi, E.A. (Eds.), Toxicology in the Tropics (pp 16-79). London: Taylor & Francis.
32. Peden, N.R., Taha, A., McSorley, P.D., Bryden, G.T., Murdoch, I.B., Anderson, J.M. (1986). Industrial exposure to hydrogen cyanide: implications for treatment. Br Med J 293:538.
33. Pettigrew, A.R., Fell, G.S. (1972). Microdiffusion method for estimation of cyanide in whole blood and its application to the study of conversion of cyanide to thiocyanate. Clin Chem 19:466-471.
34. Sies, H. (1986). Biochemistry of oxidative stress. Chem Int Ed Engl 25:1058.
35. Solomonson, L.P. (1981). Cyanide as a metabolic inhibitor. In: Venneseland, B., Conn, E.E., Knowles, C.J., Westley, J., Wissing, F. (Eds.), Cyanide Biology. London: Academia Press.
36. Soto-Blanco, B., Gorniak, S.L. (2003). Milk transfer of cyanide and thiocyanate: cyanide exposure by lactation in goats. Vet Res 34:213-220.
37. Sousa, A.B., Soto-Blanco, B., Guerra, J.L., Kimura, E.T., Gorniak, S.L. (2002). Does prolonged exposure to cyanide promote hepatotoxicity and nephrotoxicity? Toxicology 174:87-95.
38. Tulsawani, R.K., Debnath, M., Pant, S.C., Kumar, O., Prakash, A.O., Vijayaraghavan, R., et al. (2005). Effect of subacute oral cyanide administration in rats: protective efficacy of alpha-ketoglutarate and sodium thiosulfate. Chem Bio Int 156:1-12.
39. Van Heijst, A.N.P., Douze, J.M.C., Van Kesteren, R.G., Van Bergen, J., Van Dijk, A. (1987). Therapeutic problems in cyanide poisoning. Clin Toxicol 25:383-398.
40. Varma, S.D., Hegde, K.R. (2004). The effect of α-ketoglutarate against selenite cataract formation. Exp Eye Res 79:913-918.
41. Vincent, J.A., Williams, M.M., Williams, A.J., Pritsos, C.A. (1998). Effects of potassium cyanide on the synthesis of heat shock protein (HSP) 70 and 27 in mallard ducks and wistar rats. Toxicol Lett 95:236.
42. Way, J.L. (1984). Cyanide intoxication and its mechanism of antagonism. Ann Rev Pharmacol Toxicol 24:451-481.