Downsizing of enzymes by chemical methods: arginine mimics with low pk a values increase the rates of hydrolysis of RNA model compounds

Angewandte Chemie - International Edition

Volumn 48, Issue 36, 2009, Pages 6722-6725

  Lindgren, N Johan V ^b   Geiger, Lars ^a   Razkin, Jesus ^c   Schmuck, Carsten ^a   Baltzer, Lars ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UPPSALA UNIVERSITY   (Sweden)

^c PUBLIC UNIVERSITY OF NAVARRE   (Spain)

Author keywords

De novo design; Homogeneous catalysis, hydrolysis; Peptides; Phosphodiesters

Indexed keywords

ARGININE RESIDUE; CHEMICAL METHOD; DE NOVO DESIGN; HISTIDINE RESIDUES; HOMOGENEOUS CATALYSIS, HYDROLYSIS; MODEL COMPOUND; PHOSPHODIESTERS; RATE ENHANCEMENT; SIDE CHAINS;

AMINES; AMINO ACIDS; CATALYSTS; ESTERS; HYDROLYSIS; NUCLEIC ACIDS; PEPTIDES; REACTION KINETICS; RNA;

CATALYSIS;

ARGININE; ENZYME; RNA;

AMINO ACID SEQUENCE; ARTICLE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; HYDROLYSIS; MOLECULAR GENETICS; MOLECULAR MIMICRY; PH;

AMINO ACID SEQUENCE; ARGININE; CATALYTIC DOMAIN; ENZYMES; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MODELS, BIOLOGICAL; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; RNA;

EID: 70349910121     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200900595     Document Type: Article

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