Generation of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant Nurr1 mutant

Stem Cells

Volumn 27, Issue 9, 2009, Pages 2238-2246

  Jo, A Young ^a   Kim, Mi Young ^a   Lee, Hyun Seob ^a   Rhee, Yong Hee ^a   Lee, Jeong Eun ^a   Baek, Kwang Hyun ^b   Park, Chang Hwan ^a   Koh, Hyun Chul ^a   Shin, Incheol ^a   Lee, Yong Sung ^a   Lee, Sang Hun ^a  

^a Hanyang University   (South Korea)

^b CHA University   (South Korea)

Author keywords

Akt; Cell survival; Dopamine neuron; Midbrain; Nurr1; Ubiquitin proteasome system

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; NUCLEAR RECEPTOR RELATED FACTOR 1; PROTEIN KINASE B; RAF PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; IN VITRO STUDY; NONHUMAN; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RAT; UBIQUITINATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; BUTADIENES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CHROMONES; DOPAMINE; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; IMMUNOPRECIPITATION; MESENCEPHALON; MORPHOLINES; NEURONS; NITRILES; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2; PROTEIN STABILITY; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RODENTIA;

EID: 70349857799     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.146     Document Type: Article

References (35)

1. Zetterstrom RH, Solomin L, Jansson L et al. Dopamine neuron agenesis in Nurr1-deficient mice. Science 1997;276:248-250. (Pubitemid 27172681)
2. Saucedo-Cardenas O, Quintana-Hau JD, Le WD et al. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc Natl Acad Sci U S A 1998;95:4013-4018. (Pubitemid 28173245)
3. Eells JB, Lipska BK, Yeung SK et al. Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity. Behav Brain Res 2002;136:267-275.
4. Wallen A, Zetterstrom RH, Solomin L et al. Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice. Exp Cell Res 1999;253:737-746. (Pubitemid 30003136)
5. Sousa KM, Mira H, Hall AC et al. Microarray analyses support a role for Nurr1 in resistance to oxidative stress and neuronal differentiation in neural stem cells. Stem Cells 2007;25:511-519. (Pubitemid 46232807)
6. Jankovic J, Chen S, Le WD. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog Neurobiol 2005;77:128-138.
7. Chu Y, Le W, Kompoliti K et al. Nurr1 in Parkinson's disease and related disorders. J Comp Neurol 2006;494:495-514. (Pubitemid 41790998)
8. Shim JW, Park CH, Bae YC et al. Generation of functional dopamine neurons from neural precursor cells isolated from the subventricular zone and white matter of the adult rat brain using Nurr1 overexpression. Stem Cells 2007;25:1252-1262.
9. Paul G, Christophersen NS, Raymon H et al. Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line-studies in vitro and after intracerebral grafting in vivo. Mol Cell Neurosci 2007;34:390-399. (Pubitemid 46330038)
10. Park CH, Kang JS, Kim JS et al. Differential actions of the proneural genes encoding Mash1 and neurogenins in Nurr1-induced dopamine neuron differentiation. J Cell Sci 2006;119:2310-2320.
11. Kwon I, Lee J, Chang SH et al. BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer. Mol Cell Biol 2006;26:7318-7330. (Pubitemid 44477705)
12. Shim JW, Koh HC, Chang MY et al. Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL. J Neurosci 2004;24:843-852.
13. Abercrombie M. Estimation of nuclear populations from microtomesections. Anat Rec 1946;94:239-247.
14. Park CH, Kang JS, Shin YH et al. Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons. FASEB J 2006;20:2553-2555.
15. Kim JY, Koh HC, Lee JY et al. Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression. J Neurochem 2003;85:1443-1454. (Pubitemid 36702557)
16. Kudo N, Matsumori N, Taoka H et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A 1999;96:9112-9117. (Pubitemid 29374716)
17. O'Driscoll C, Wallace D, Cotter T. bFGF promotes photoreceptor cell survival in vitro by PKA-mediated inactivation of glycogen synthase kinase 3beta and CREB-dependent Bcl-2 up-regulation. J Neurochem 2007;103:860-870. (Pubitemid 47568733)
18. Johnson-Farley N, Patel K, Kim D et al. Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt, ERK, and neuronal survival in hippocampal. Cultures 2007;1154:40-49.
19. Zimmermann S, Moelling K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 1999;286:1741-1744. (Pubitemid 129515882)
20. Menges CW, McCance DJ. Constitutive activation of the Raf-MAPK pathway causes negative feedback inhibition of Ras-PI3K-AKT and cellular arrest through the EphA2 receptor. Oncogene 2008;27:2934-2940.
21. Sacchetti P, Carpentier R, Segard P et al. Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1. Nucleic Acids Res 2006;34:5515-5527. (Pubitemid 44742440)
22. Zhang T, Jia N, Fei E et al. Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells. Neurosci Lett 2007;423:118-122. (Pubitemid 47259592)
23. Brockman JA, Scherer DC, McKinsey TA et al. Coupling of a signal response domain in I kappa B alpha to multiple pathways for NFkappa B activation. Mol Cell Biol 1995;15:2809-2818.
24. Ganoth D, Bornstein G, Ko TK et al. The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol 2001;3:321-324. (Pubitemid 32201330)
25. Koepp DM, Schaefer LK, Ye X et al. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 2001;294:173-177. (Pubitemid 32952972)
26. Floyd ZE, Stephens JM. Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes. J Biol Chem 2002;277:4062-4068.
27. Nie L, Xu M, Vladimirova A et al. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J 2003;22:5780-5792. (Pubitemid 37408817)
28. Lin HK, Wang L, Hu YC et al. Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J 2002;21:4037-4048. (Pubitemid 34857436)
29. Malmlof M, Roudier E, Hogberg J et al. MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signaling. J Biol Chem 2007;282:2288-2296. (Pubitemid 47076785)
30. Alarid ET. Lives and times of nuclear receptors. Mol Endocrinol 2006;20:1972-1981.
31. Arenas E. Engineering a dopaminergic phenotype in stem/precursor cells: role of Nurr1, glia-derived signals, and Wnts. Ann N Y Acad Sci 2005;1049:51-66. (Pubitemid 40967575)
32. Li JY, Englund E, Holton JL et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 2008;14:501-503. (Pubitemid 351655211)
33. Jiang C, Wan X, He Y et al. Age-dependent dopaminergic dysfunction in Nurr1 knockout mice. Exp Neurol 2005;191:154-162. (Pubitemid 39612401)
34. Yi SH, Jo AY, Park CH et al. Mash1 and neurogenin 2 enhance survival and differentiation of neural precursor cells after transplantation to rat brains via distinct modes of action. Mol Ther 2008;16:1873-1882.
35. Hofstetter CP, Holmström NA, Lilja JA et al. Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat Neurosci 2005;8:346-353.