Expression of Epidermal Growth Factor Receptor variant III in laryngeal carcinoma tissues

Auris Nasus Larynx

Volumn 36, Issue 6, 2009, Pages 682-687

  Yang, Beibei ^a   Chen, Jia ^a   Zhang, Xing ^b   Cao, Jiang ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Laryngeal neoplasms; Oncogene; Polymerase chain reaction (PCR); Squamous cell; Variation

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 3; MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC VARIABILITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LARYNGECTOMY; LARYNX CARCINOMA; LARYNX MUCOSA; MALE; MICROSCOPY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TISSUE DIFFERENTIATION; TUMOR LOCALIZATION;

ADULT; AGED; BIOPSY; CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME DELETION; EXONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LARYNGEAL MUCOSA; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; RECEPTOR, EPIDERMAL GROWTH FACTOR; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 70349826883     PISSN: 03858146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anl.2009.03.002     Document Type: Article

References (17)

1. Moghal N., and Sternberg P.W. Multiple positive and negative regulators of signaling by the EGF-receptor. Curr Opin Cell Biol 11 (1999) 190-196
2. Herbst R.S., and Shin D.M. Monoclonal antibodies to target epidermal growth factor-positive tumors: a new paradigm for cancer therapy. Cancer 94 (2002) 1593-1611
3. Tang C.K., Gong X.Q., Moscatello D.K., Wong A.J., and Lippman M.E. Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer. Cancer Res 60 (2000) 3081-3087
4. Humphrey P.A., Wong A.J., Vogelstein B., Zalutsky M.R., Fuller G.N., Archer G.E., et al. Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptor in human glioblastoma. Proc Natl Acad Sci USA 87 (1990) 4207-4211
5. Rae J.M., Scheys J.O., Clark K.M., Chadwick R.B., Kiefer M.C., and Lippman M.E. EGFR and EGFRvIII expression in primary breast cancer and cell lines. Breast Cancer Res Treat 87 (2004) 87-95
6. Nieto Y., Nawaz F., Jones R.B., Shpall E.J., and Nawaz S. Prognostic significance of over expression and phosphorylation of epidermal growth factor receptor (EGFR) and the presence of truncated EGFRvIII in locoregionally advanced breast cancer. J Clin Oncol 25 (2007) 4405-4413
7. Moscatello D.K., Holgado-Madruga M., Godwm A.K., Ramirez G., Gunn G., Zoltick P.W., et al. Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors. Cancer Res 55 (1995) 5536-5539
8. Olapade-Olaopa E.O., Moscatello D.K., MacKay E.H., Sandhu D.P., Terry T.R., Wong A.J., et al. Alterations in the expression of androgen receptor, wild type-epidermal growth factor receptor and a mutant epidermal growth factor receptor in human prostate cancer. Afr J Med Med Sci 33 (2004) 245-253
9. Mishima K., Johns T.G., and Luwor R.B. Growth suppression of intracranial xenografted glioblastoma overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb)806, a novel monoclonal antibody directed to the receptor. Cancer Res 61 (2001) 5349-5354
10. An Y., Ji J., Wu W., Lv A., Huang R., and Wei Y. A rapid and efficient method for multiple-site mutagenesis with a modified overlap extension PCR. Appl Microbiol Biotechnol 68 (2005) 774-778
11. -ΔΔCT. Methods 25 (2001) 402-408
12. Garcia de Palazzo I.E., Adams G., Sundareshan P., Wong A.J., Testa J.R., Bigner D.D., et al. Expression of mutated epidermal growth factor receptor by non-small cell lung carcinoma. Cancer Res 53 (1993) 3217-3220
13. Ge H., Gong X., and Tang C.K. Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis. Int J Cancer 98 (2002) 357-361
14. Bustin S.A. Absolute quantitation of mRNA using real-time reverse transcription polymerase chain reaction assay. J Mol Endocrinol 25 (2000) 169-193
15. Sasaki H., Kawano O., Endo K., Yukiue H., Yano M., and Fujii Y. EGFRvIII mutation in lung cancer correlates with increased EGFR copy number. Oncol Rep 17 (2007) 319-323
16. Almadori G., Bussu F., Cadoni G., Galli J., Paludetti G., and Maurizi M. Molecular markers in laryngeal squamous cell carcinoma: towards an integrated clinicobiological approach. Eur J Cancer 41 (2005) 683-693
17. Pedersen M.W., Meltorn M., Damstrup L., and Poulsen H.S. The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy. Ann Oncol 12 (2001) 745-760