Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: Antagonism by Bacopa monnieri

Epilepsy and Behavior

Volumn 16, Issue 2, 2009, Pages 225-230

  Krishnakumar, Amee ^a   Nandhu, M S ^a   Paulose, C S ^a  

^a Centre for Neuroscience   (India)

Author keywords

5 HT2C receptor; Bacopa monnieri; Depression; Epilepsy; Hippocampus; Natural product

Indexed keywords

BACOPA MONNIERI EXTRACT; CARBAMAZEPINE; INOSITOL TRISPHOSPHATE; SEROTONIN 2C RECEPTOR; ANTICONVULSIVE AGENT; ERGOLINE DERIVATIVE; INOSITOL 1,4,5 TRISPHOSPHATE; MESULERGINE; PILOCARPINE; PLANT MEDICINAL PRODUCT; SEROTONIN ANTAGONIST; TRITIUM;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CLINICAL FEATURE; CONTROLLED STUDY; DEPRESSION; DRUG MECHANISM; DRUG RECEPTOR BINDING; EPILEPSY; FORCED SWIMMING TEST; GENE EXPRESSION; HIPPOCAMPUS; MALE; NONHUMAN; PROTEIN ANALYSIS; RAT; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; TEMPORAL LOBE EPILEPSY; ANIMAL; BACOPA; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; GENETICS; METABOLISM; METHODOLOGY; NONPARAMETRIC TEST; PATHOLOGY; PROTEIN BINDING; RADIOASSAY; SWIMMING; UPREGULATION; WISTAR RAT;

ANIMALS; ANTICONVULSANTS; BACOPA; CARBAMAZEPINE; DISEASE MODELS, ANIMAL; EPILEPSY; ERGOLINES; HIPPOCAMPUS; INOSITOL 1,4,5-TRISPHOSPHATE; MALE; PILOCARPINE; PLANT PREPARATIONS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN ANTAGONISTS; STATISTICS, NONPARAMETRIC; SWIMMING; TRITIUM; UP-REGULATION;

EID: 70349798692     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2009.07.031     Document Type: Article

References (45)

1. 2C receptor mutant mice. Proc Natl Acad Sci USA 95 (1998) 15026-15031
2. Steinbusch H.W.M. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6 (1981) 557-618
3. Behr J., Lyson K.J., and Mody I. Enhanced propagation of epileptiform activity through the kindled dentate gyrus. J Neurophysiol 79 (1998) 1726-1732
4. Collins R.C., Tearse R.G., and Lothman E.W. Functional anatomy of limbic seizures: focal discharges from medial entorhinal cortex in rat. Brain Res 280 (1983) 25-40
5. Reas S.K., Amee K., and Paulose C.S. Glutamate receptor gene expression and binding studies in pilocarpine induced epileptic rat: neuroprotective role of Bacopa monnieri extract. Epilepsy Behav 12 (2007) 54-60
6. Buzsaki G. Theta oscillations in the hippocampus. Neuron 33 (2002) 325-340
7. Hasselmo M.E., Bodelon C., and Wyble B.P. A proposed function for hippocampal theta rhythm: separate phases of encoding and retrieval enhance reversal of prior learning. Neural Comput 14 (2002) 793-817
8. Raghavachari S., Kahana M.J., Rizzuto D.S., et al. Gating of human theta oscillations by a working memory task. J Neurosci 21 (2001) 3175-3183
9. Isokawa M., and Mello L.E. NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats. Neurosci Lett 129 (1991) 69-73
10. Kanner A.M. Depression and epilepsy: a new perspective on two closely related disorders. Epilepsy Curr 6 (2006) 141-146
11. Blumer D., Montouris G., and Davies K. The interictal dysphoric disorder: recognition, pathogenesis, and treatment of the major psychiatric disorder of epilepsy. Epilepsy Behav 5 (2004) 826-840
12. Hajszan T., and MacLusky N.J. Neurologic links between epilepsy and depression in women: is hippocampal neuroplasticity the key?. Neurology 66 (2006) S13-S22
13. Aithal H.N., and Sirsi M. Pharmacological investigation on Herpestis monniera. Indian J Pharmacol 23 (1961) 2-5
14. Malhotra C.L., and Das P.K. Pharmacological studies of Herpestis monniera Linn (Brahmi). Indian J Med Res 47 (1959) 294-305
15. Prakash J.C., and Sirsi M. Comparative study of the effects of Brahmi (Bacopa monniera) and chlopromazine on motor learning in rats. J Sci Ind Res 21 (1962) 93-96
16. Shanker G., and Singh H.K. Anxiolytic profile of standardized Brahmi extract. Indian J Pharmacol 32 (2000) 152
17. Sairam K., Dorababu M., Goel R.K., and Bhattacharya S.K. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine 9 (2002) 207-211
18. Shanmugasundaram E.R., Akbar G.K., and Shanmugasundaram K.R. Brahmighritham. An Ayurvedic herbal formula for the control of epilepsy. J Ethnopharmacol 33 (1991) 269-276
19. Singh S., Eapen S., and D'Souza S.F. Cadmium accumulation and its influence on lipid peroxidation and antioxidative system in an aquatic plant, Bacopa monnieri L. Chemosphere 62 (2006) 233-246
20. Heffner T.G., Hartman J.A., and Seiden L.S. A rapid method for the regional dissection of the rat brain. Pharmacol Biochem Behav 13 (1980) 453-456
21. Paulose C.S., Chathu F., Khan R.S., and Krishnakumar A. Neuroprotective role of Bacopa monnieri extract in epilepsy and effect of glucose supplementation during hypoxia: glutamate receptor gene expression. Neurochem Res 33 (2008) 1663-1671
22. Racine R.J. Modification of seizure activity by electrical stimulation: after discharge threshold. Electroencephalogr Clin Neurophysiol 32 (1972) 269-279
23. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurements and the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
24. 2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. J Neurochem 73 (1999) 1711-1717
25. Scatchard G. The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51 (1949) 660-672
26. Porsolt R.D., Le Pichon M., and Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 266 (1977) 730-732
27. Millan M.J., Dekeyne A., Papp M., et al. S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram and clomipramine. J Pharmacol Exp Ther 298 (2001) 581-591
28. Menard J., and Treit D. Effects of centrally administered anxiolytic compounds in animal models of anxiety. Neurosci Biobehav Rev 23 (1999) 591-613
29. 2C receptors within the basolateral amygdala induces acute fear-like responses in an open-field environment. Brain Res 993 (2003) 1-9
30. 2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306 (2003) 954-964
31. 2C agonists into ventral but not dorsal hippocampus. Behav Pharmacol 15 (2004) 37-43
32. 2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models. Psychopharmacology 199 (2008) 549-568
33. 2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie 60 (2005) 441-460
34. Giorgetti M., and Tecott L.H. Contributions of 5-HT2C receptors to multiple actions of central serotonin systems. Eur J Pharmacol 488 (2004) 1-9
35. Di Giovanni G., Di Matteo V., Pierucci M., Benigno A., and Esposito E. Central serotonin 2C receptor: from physiology to pathology. Curr Top Med Chem 6 (2006) 1909-1925
36. Bos M., Jenck F., Martin J.R., et al. Novel agonists of 5HT2C receptors: synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1, 2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder. J Med Chem 40 (1997) 2762-2769
37. Fone K.C., Austin R.H., Topham I.A., Kennett G.A., and Punhani T. Effect of chronic m-CPP on locomotion, hypophagia, plasma corticosterone and 5-HT2C receptor levels in the rat. Br J Pharmacol 123 (1998) 1707-1715
38. Reas KS. Muscarinic M1 and glutamate receptor gene expression and their functional role in pilocarpine induced temporal lobe epilepsy in rats: regulation by bacoside A and Bacopa monnieri extracts. Thesis submitted in partial fulfilment for the requirement of Ph.D. to Cochin University of Science and Technology; 2007. p. 6.
39. Singh H.K., and Dhawan B.N. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monnieri Linn (Brahmi). Indian J Pharmacol 29 (1997) S359-S365
40. Bhattacharya S.K., and Ghosal S. Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study. Phytomedicine 5 (1998) 77-82
41. Bhattacharya S.K., Kumar A., and Ghosal S. Effect of Bacopa monniera on animal models of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats. Res Commun Pharmacol Toxicol 4 (1999) II1-II12
42. Das A., Shanker G., Nath C., Pal R., Singh S., and Singh H. A comparative study in rodents of standardized extracts of Bacopa monniera and ginkgo biloba. Pharmacol Biochem Behav 73 (2002) 893-900
43. Boehning D., Patterson R.L., Sedaghat L., Glebova N.O., Kurosaki T., and Snyder S.H. Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nature Cell Biol 5 (2003) 1051-1061
44. Mazarati A., Siddarth P., Baldwin R.A., Shin D., Caplan R., and Sankar R. Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. Brain 131 (2008) 2071-2083
45. Nigel J.C., Salzberg M.R., Gaurav K., Abbie C., Margaret J.M., and Terence J.O. Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation. Exp Neurol 209 (2008) 254-260