Falsely elevated hemoglobin A1c due to S-β+-thalassemia interference in Bio-Rad Variant II Turbo HbA1c assay

Clinica Chimica Acta

Volumn 409, Issue 1-2, 2009, Pages 18-20

  Zhu, Yusheng ^a   Williams, Laurie M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cation exchange HPLC; Hemoglobin A1c; Hemoglobin S + thalassemia; Interference

Indexed keywords

HEMOGLOBIN A1C; HEMOGLOBIN A2; HEMOGLOBIN F; HEMOGLOBIN S;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA THALASSEMIA; CASE REPORT; DIABETES MELLITUS; DIAGNOSTIC VALUE; HEMOGLOBIN DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION EXCHANGE CHROMATOGRAPHY; PRIORITY JOURNAL; TURBIDIMETRY;

ARTIFACTS; BETA-THALASSEMIA; BLOOD CHEMICAL ANALYSIS; DIABETES COMPLICATIONS; DIABETES MELLITUS; FALSE POSITIVE REACTIONS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS;

EID: 70349795485     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2009.08.009     Document Type: Article

References (14)

1. Bry L., Chen P.C., and Sacks D.B. Effects of hemoglobin variants and chemically modified derivatives on assays for glycohemoglobin. Clin Chem 47 (2001) 153-163
2. Al-Fadhli S.M., Ahmad A.A., and Al-Jafar H.A. Effect of sickle cell trait and B-thalassemia minor on determinations of HbA1c by an immunoassay method. Saudi Med J 22 (2001) 686-689
3. Eberentz-Lhomme C., Ducrocq R., Intrator S., Elion J., Nunez E., and Assan R. Haemoglobinopathies: a pitfall in the assessment of glycosylated haemoglobin by ion-exchange chromatography. Diabetologia 27 (1984) 596-598
4. Polage C., Little R.R., Rohlfing C.L., Cole T.G., and Roberts W.L. Effects of beta thalassemia minor on results of six glycated hemoglobin methods. Clin Chim Acta 350 (2004) 123-128
5. Saitta G., Catalano C., Artenisio A.C., and Filardo O. Glycosylated haemoglobin in carriers of beta thalassaemia trait. Br Med J 289 (1984) 1382-1383
6. Sridama V., Hansasuta P., Pasatrat S., and Bunnag S. Evaluation of diabetic control by using hemoglobin A1 and fructosamine. J Med Assoc Thai 73 (1990) 130-135
7. Weykamp C.W., Penders T.J., Muskiet F.A., and van der Slik W. Influence of hemoglobin variants and derivatives on glycohemoglobin determinations, as investigated by 102 laboratories using 16 methods. Clin Chem 39 (1993) 1717-1723
8. Sarnaik S.A. Thalassemia and related hemoglobinopathies. Indian J Pediatr 72 (2005) 319-324
9. Hoyer J.D., and Hoffman D.R. The thalassemia and hemoglobinopathy syndromes. In: McClatchey K.D. (Ed). Clinical Laboratory Medicine (2002), Lippincott Williams & Wilkins, Pheladelphia 886
10. Mongia S.K., Little R.R., Rohlfing C.L., et al. Effects of hemoglobin C and S traits on the results of 14 commercial glycated hemoglobin assays. Am J Clin Pathol 130 (2008) 136-140
11. Roberts W.L., Safar-Pour S., De B.K., Rohlfing C.L., Weykamp C.W., and Little R.R. Effects of hemoglobin C and S traits on glycohemoglobin measurements by eleven methods. Clin Chem 51 (2005) 776-778
12. Little R.R., Rohlfing C.L., Hanson S., et al. Effects of hemoglobin (Hb) E and HbD traits on measurements of glycated Hb (HbA1c) by 23 methods. Clin Chem 54 (2008) 1277-1282
13. Pravatmuang P., Sae-Ngow B., Whanpuch T., and Leowattana W. Effect of HbE and HbH on HbA1C level by ionic exchange HPLC comparing to immunoturbidimetry. Clin Chim Acta 313 (2001) 171-178
14. Kosecki S.M., Rodgers P.T., and Adams M.B. Glycemic monitoring in diabetics with sickle cell plus beta-thalassemia hemoglobinopathy. Ann Pharmacother 39 (2005) 1557-1560