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1
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0037086131
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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
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Essential reading for anyone wishing to understand NK alloreactivity and why it is relevant to stem cell transplantation.
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Ruggeri L., Capanni M., Urbani E., Perruccio K., Shlomchik W.D., Tosti A., Posati S., Rogaia D., Frassoni F., Aversa F., et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295 (2002) 2097-2100. Essential reading for anyone wishing to understand NK alloreactivity and why it is relevant to stem cell transplantation.
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Science
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Ruggeri, L.1
Capanni, M.2
Urbani, E.3
Perruccio, K.4
Shlomchik, W.D.5
Tosti, A.6
Posati, S.7
Rogaia, D.8
Frassoni, F.9
Aversa, F.10
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2
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0024557888
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Evidence that large granular lymphocytes of donor origin mediate acute graft-versus-host disease
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Ferrara J.L., Guillen F.J., van Dijken P.J., Marion A., Murphy G.F., and Burakoff S.J. Evidence that large granular lymphocytes of donor origin mediate acute graft-versus-host disease. Transplantation 47 (1989) 50-54
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Transplantation
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Ferrara, J.L.1
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Marion, A.4
Murphy, G.F.5
Burakoff, S.J.6
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Role of natural killer cells in the pathogenesis of human acute graft-versus-host disease
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Rhoades J.L., Cibull M.L., Thompson J.S., Henslee-Downey P.J., Jennings C.D., Sinn H.P., Brown S.A., Eichhorn T.R., Cave M.L., and Jezek D.A. Role of natural killer cells in the pathogenesis of human acute graft-versus-host disease. Transplantation 56 (1993) 113-120
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Transplantation
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Rhoades, J.L.1
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Jennings, C.D.5
Sinn, H.P.6
Brown, S.A.7
Eichhorn, T.R.8
Cave, M.L.9
Jezek, D.A.10
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4
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0023242444
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Graft-versus-host reactions in the beige mouse. An investigation of the role of host and donor natural killer cells in the pathogenesis of graft-versus-host disease
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Ghayur T., Seemayer T.A., Kongshavn P.A., Gartner J.G., and Lapp W.S. Graft-versus-host reactions in the beige mouse. An investigation of the role of host and donor natural killer cells in the pathogenesis of graft-versus-host disease. Transplantation 44 (1987) 261-267
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Ghayur, T.1
Seemayer, T.A.2
Kongshavn, P.A.3
Gartner, J.G.4
Lapp, W.S.5
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5
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33847072633
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Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor
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A well-designed study with large numbers of patients receiving transplants under relatively uniform transplant protocol. Very convincingly demonstrates effects of ligand incompatibility and separates effects of ligand incompatibility from HLA-C allele mismatching.
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Morishima Y., Yabe T., Matsuo K., Kashiwase K., Inoko H., Saji H., Yamamoto K., Maruya E., Akatsuka Y., Onizuka M., et al. Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor. Biol Blood Marrow Transplant 13 (2007) 315-328. A well-designed study with large numbers of patients receiving transplants under relatively uniform transplant protocol. Very convincingly demonstrates effects of ligand incompatibility and separates effects of ligand incompatibility from HLA-C allele mismatching.
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Biol Blood Marrow Transplant
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Morishima, Y.1
Yabe, T.2
Matsuo, K.3
Kashiwase, K.4
Inoko, H.5
Saji, H.6
Yamamoto, K.7
Maruya, E.8
Akatsuka, Y.9
Onizuka, M.10
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6
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33746096999
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The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registry
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A large study providing convincing evidence that ligand incompatibility results in poorer outcome relative to HLA matched transplants. Sufficiently powered to demonstrate that ligand mismatching did not produce a more deleterious effect than HLA-C and HLA-B allele mismatching.
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Farag S.S., Bacigalupo A., Eapen M., Hurley C., Dupont B., Caligiuri M.A., Boudreau C., Nelson G., Oudshoorn M., van Rood J., et al. The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registry. Biol Blood Marrow Transplant 12 (2006) 876-884. A large study providing convincing evidence that ligand incompatibility results in poorer outcome relative to HLA matched transplants. Sufficiently powered to demonstrate that ligand mismatching did not produce a more deleterious effect than HLA-C and HLA-B allele mismatching.
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Biol Blood Marrow Transplant
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Farag, S.S.1
Bacigalupo, A.2
Eapen, M.3
Hurley, C.4
Dupont, B.5
Caligiuri, M.A.6
Boudreau, C.7
Nelson, G.8
Oudshoorn, M.9
van Rood, J.10
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7
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33746031836
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KIR ligands and prediction of relapse after unrelated donor hematopoietic cell transplantation for hematologic malignancy
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A large study that failed to find any effect of ligand incompatibility but did find evidence that the missing ligand model results in decreased relapse. This study demonstrates that even well-powered studies will not necessarily detect effects of ligand incompatibility.
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Hsu K.C., Gooley T., Malkki M., Pinto-Agnello C., Dupont B., Bignon J.D., Bornhauser M., Christiansen F., Gratwohl A., Morishima Y., et al. KIR ligands and prediction of relapse after unrelated donor hematopoietic cell transplantation for hematologic malignancy. Biol Blood Marrow Transplant 12 (2006) 828-836. A large study that failed to find any effect of ligand incompatibility but did find evidence that the missing ligand model results in decreased relapse. This study demonstrates that even well-powered studies will not necessarily detect effects of ligand incompatibility.
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(2006)
Biol Blood Marrow Transplant
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Hsu, K.C.1
Gooley, T.2
Malkki, M.3
Pinto-Agnello, C.4
Dupont, B.5
Bignon, J.D.6
Bornhauser, M.7
Christiansen, F.8
Gratwohl, A.9
Morishima, Y.10
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8
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37349058596
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Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation
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A large well-designed study that demonstrates the potential for NK alloreactivity to have opposite effects under different transplant protocols.
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Yabe T., Matsuo K., Hirayasu K., Kashiwase K., Kawamura-Ishii S., Tanaka H., Ogawa A., Takanashi M., Satake M., Nakajima K., et al. Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation. Biol Blood Marrow Transplant 14 (2008) 75-87. A large well-designed study that demonstrates the potential for NK alloreactivity to have opposite effects under different transplant protocols.
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(2008)
Biol Blood Marrow Transplant
, vol.14
, pp. 75-87
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Yabe, T.1
Matsuo, K.2
Hirayasu, K.3
Kashiwase, K.4
Kawamura-Ishii, S.5
Tanaka, H.6
Ogawa, A.7
Takanashi, M.8
Satake, M.9
Nakajima, K.10
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9
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60249098439
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Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia
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A large well-powered study demonstrating the influence of donor KIR repertoire.
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Cooley S., Trachtenberg E., Bergemann T.L., Saeteurn K., Klein J., Le C.T., Marsh S.G., Guethlein L.A., Parham P., Miller J.S., and Weisdorf D.J. Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia. Blood 113 (2009) 726-732. A large well-powered study demonstrating the influence of donor KIR repertoire.
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(2009)
Blood
, vol.113
, pp. 726-732
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Cooley, S.1
Trachtenberg, E.2
Bergemann, T.L.3
Saeteurn, K.4
Klein, J.5
Le, C.T.6
Marsh, S.G.7
Guethlein, L.A.8
Parham, P.9
Miller, J.S.10
Weisdorf, D.J.11
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10
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Hematopoietic stem cell transplantation: killer immunoglobulin-like receptor component
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Hsu K.C., Pinto-Agnello C., Gooley T., Malkki M., Dupont B., and Petersdorf E.W. Hematopoietic stem cell transplantation: killer immunoglobulin-like receptor component. Tissue Antigens 69 Suppl 1 (2007) 42-45
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Tissue Antigens
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Hsu, K.C.1
Pinto-Agnello, C.2
Gooley, T.3
Malkki, M.4
Dupont, B.5
Petersdorf, E.W.6
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11
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Activating killer immunoglobulin-like receptor incompatibilities enhance graft-versus host disease and affect survival after allogeneic hematopoietic stem cell transplantation
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ePub ahead of print. One of the few studies to evaluate more than one method of analysing the effects of KIR repertoire on outcome.
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Giebel S., Nowak I., Dziaczkowska J., Czerw T., Wojnar J., Krawczyk-Kulis M., Holowiecki J., Holowiecka-Goral A., Markiewicz M., Kopera M., et al. Activating killer immunoglobulin-like receptor incompatibilities enhance graft-versus host disease and affect survival after allogeneic hematopoietic stem cell transplantation. Eur J Haematol (2009) ePub ahead of print. One of the few studies to evaluate more than one method of analysing the effects of KIR repertoire on outcome.
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(2009)
Eur J Haematol
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Giebel, S.1
Nowak, I.2
Dziaczkowska, J.3
Czerw, T.4
Wojnar, J.5
Krawczyk-Kulis, M.6
Holowiecki, J.7
Holowiecka-Goral, A.8
Markiewicz, M.9
Kopera, M.10
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12
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The impact of immunosuppressive therapy on an early quantitative NK cell reconstitution after allogeneic haematopoietic cell transplantation
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Giebel S., Dziaczkowska J., Wojnar J., Krawczyk-Kulis M., Markiewicz M., Kruzel T., Wylezol I., Nowak K., Jagoda K., and Holowiecki J. The impact of immunosuppressive therapy on an early quantitative NK cell reconstitution after allogeneic haematopoietic cell transplantation. Ann Transplant 10 (2005) 29-33
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Giebel, S.1
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Wojnar, J.3
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Markiewicz, M.5
Kruzel, T.6
Wylezol, I.7
Nowak, K.8
Jagoda, K.9
Holowiecki, J.10
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13
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Natural killer cell activity and antibody-dependent cellular cytotoxicity in patients under various immunosuppressive regimens
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Wang H., Grzywacz B., Sukovich D., McCullar V., Cao Q., Lee A.B., Blazar B.R., Cornfield D.N., Miller J.S., and Verneris M.R. The unexpected effect of cyclosporin A on CD56+. Blood 110 (2007) 1530-1539
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Verneris, M.R.10
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Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor
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Davies S.M., Ruggieri L., DeFor T., Wagner J.E., Weisdorf D.J., Miller J.S., Velardi A., and Blazar B.R. Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood 100 (2002) 3825-3827
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Davies, S.M.1
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DeFor, T.3
Wagner, J.E.4
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Miller, J.S.6
Velardi, A.7
Blazar, B.R.8
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16
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HLA natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants
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De Santis D., Bishara A., Witt C.S., Nagler A., Brautbar C., Slavin S., and Christiansen F.T. HLA natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants. Tissue Antigens 65 (2005) 519-528
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De Santis, D.1
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Bornhauser M., Schwerdtfeger R., Martin H., Frank K.H., Theuser C., Ehninger G., Locatelli F., Velardi A., and Giebel S. Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors. Blood 103 (2004) 2860-2861
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Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation
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Schaffer M., Malmberg K.J., Ringden O., Ljunggren H.G., and Remberger M. Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation. Transplantation 78 (2004) 1081-1085
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Remberger, M.5
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Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation
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Kroger N., Binder T., Zabelina T., Wolschke C., Schieder H., Renges H., Ayuk F., Dahlke J., Eiermann T., and Zander A. Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation. Transplantation 82 (2006) 1024-1030
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Transplantation
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Kroger, N.1
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T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation
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Lowe E.J., Turner V., Handgretinger R., Horwitz E.M., Benaim E., Hale G.A., Woodard P., and Leung W. T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation. Br J Haematol 123 (2003) 323-326
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Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT
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Miller J.S., Cooley S., Parham P., Farag S.S., Verneris M.R., McQueen K.L., Guethlein L.A., Trachtenberg E.A., Haagenson M., Horowitz M.M., et al. Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT. Blood 109 (2007) 5058-5061
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Hsu K.C., Keever-Taylor C.A., Wilton A., Pinto C., Heller G., Arkun K., O'Reilly R.J., Horowitz M.M., and Dupont B. Improved outcome in HLA-identical sibling hematopoietic stem cell transplantation for acute myelogenous leukemia (AML) predicted by KIR and HLA genotypes. Blood 105 (2005) 4878-4884
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Dupont, B.9
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23
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Killer Ig-like receptor (KIR) compatibility plays a role in the prevalence of acute GVHD in unrelated hematopoietic cell transplants for AML
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Sun J.Y., Gaidulis L., Dagis A., Palmer J., Rodriguez R., Miller M.M., Forman S.J., and Senitzer D. Killer Ig-like receptor (KIR) compatibility plays a role in the prevalence of acute GVHD in unrelated hematopoietic cell transplants for AML. Bone Marrow Transplant 36 (2005) 525-530
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Reduced risk for molecular disease in patients with chronic myeloid leukemia after transplantation from a KIR-mismatched donor
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Martinetti, M.10
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Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias
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Beelen D.W., Ottinger H.D., Ferencik S., Elmaagacli A.H., Peceny R., Trenschel R., and Grosse-Wilde H. Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias. Blood 105 (2005) 2594-2600
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Comparison between antithymocyte globulin and alemtuzumab and the possible impact of KIR-ligand mismatch after dose-reduced conditioning and unrelated stem cell transplantation in patients with multiple myeloma
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Kroger N., Shaw B., Iacobelli S., Zabelina T., Peggs K., Shimoni A., Nagler A., Binder T., Eiermann T., Madrigal A., et al. Comparison between antithymocyte globulin and alemtuzumab and the possible impact of KIR-ligand mismatch after dose-reduced conditioning and unrelated stem cell transplantation in patients with multiple myeloma. Br J Haematol 129 (2005) 631-643
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