TGF-β modulates the functionality of tumor-infiltrating CD8 + T cells through effects on TCR signaling and Spred1 expression

Cancer Immunology, Immunotherapy

Volumn 58, Issue 11, 2009, Pages 1811-1820

  Di Bari, Maria Giovanna ^a   Lutsiak, M E Christine ^a   Takai, Shinji ^a   Mostböck, Sven ^a   Farsaci, Benedetto ^a   Tolouei Semnani, Roshanak ^b   Wakefield, Lalage M ^a   Schlom, Jeffrey ^a   Sabzevari, Helen ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Signal transduction; T cells; Tolerance suppression anergy; Tumor immunity

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN SPRED1; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; GAMMA INTERFERON; LYMPHOCYTE ANTIGEN RECEPTOR; REPRESSOR PROTEIN; SPRED1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; ENZYME INDUCTION; EX VIVO STUDY; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; MEMORY T LYMPHOCYTE; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SPLEEN CELL; TUMOR ASSOCIATED LEUKOCYTE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG ANTAGONISM; EXPERIMENTAL NEOPLASM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNE TOLERANCE; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, TUMOR-INFILTRATING; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 70349786181     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-009-0692-9     Document Type: Article

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