Clinical trial to compare the effectiveness of two concentrations of the Ageratina pichinchensis extract in the topical treatment of onychomycosis

Journal of Ethnopharmacology

Volumn 126, Issue 1, 2009, Pages 74-78

  Romero Cerecero, Ofelia ^a,b   Román Ramos, Rubén ^b   Zamilpa, Alejandro ^a   Jiménez Ferrer, Jesús Enrique ^a   Rojas Bribiesca, Gabriela ^a   Tortoriello, Jaime ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b UNIVERSIDAD AUTÓNOMA METROPOLITANA   (Mexico)

Author keywords

Ageratina pichinchensis; Asteraceae; Onychomycosis; Topical treatment; Trychophyton rubrum

Indexed keywords

AGERATINA PICHINCHENSIS EXTRACT; COSMETIC; NAIL LACQUER; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; AGED; AGERATINA PICHINCHENSIS; ARTICLE; CLINICAL TRIAL; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG TOLERABILITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEXICO; MYCOSIS; ONYCHOMYCOSIS; PLANT; TRADITIONAL MEDICINE; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, TOPICAL; ADULT; AGED; AGERATINA; ANTIFUNGAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MEDICINE, TRADITIONAL; MIDDLE AGED; ONYCHOMYCOSIS; PHYTOTHERAPY; PLANT EXTRACTS;

AGERATINA; ASTERACEAE; TRICHOPHYTON RUBRUM;

EID: 70349784439     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.08.007     Document Type: Article

References (22)

1. Argueta A., Cano L., and Rodarte M. Atlas de La Medicina Tradicional Mexicana, Tomo 1-3 (1994), Instituto Nacional Indigenista, México, D.F. p. 1786
2. Avilés M., and Suárez G. Catálogo de Plantas Medicinales Jardín Etnobotánico (1994), Centro INAH, Cuernavaca, Morelos, México p. 47
3. Casciano J., Amaya K., Doyle J., Arikian S., Shear N., Haspel M., and Kahler K. Economic analysis of oral and topical therapies for onychomycosis of the toenails and fingernails. Managed Care 12 (2003) 47-54
4. Gupta A.K. Pharmacoeconomic analysis of ciclopirox nail lacquer solution 8% and the new oral antifungal agents used to treat dermatophyte toe onychomycosis in the United States. Journal of the American Academy of Dermatology 43 (2000) S81-S95
5. Gupta A.K., Cooper E.A., Ryder J.E., Nicol K.A., Chow M., and Chaudhry M.M. Optimal management of fungal infections of the skin, hair, and nails. American Journal of Clinical Dermatology 5 (2004) 225-237
6. Gupta A.K., and Cooper E.A. Update in antifungal therapy of dermatophytosis. Mycopathologia 166 (2008) 353-367
7. Gupta A.K., Ryder J.E., Chow M., and Cooper E.A. Dermatophytosis: the management of fungal infections. Skinmed 4 (2005) 305-310
8. Gupta A.K., Ryder J.E., and Johnson A.M. Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis. The British Journal of Dermatology 150 (2004) 537-544
9. Gupta A.K., Poulin Y., and Lynde C.W. Canadian perspectives on antifungal treatment for onychomycosis. Journal of Cutaneous Medicine and Surgery 10 Suppl. 2 (2006) S34-S38
10. Lecha M., Effendy I., Feuilhade de Chauvin M., Di Chiacchio N., and Baran R. Taskforce on Onychomycosis Education. Treatment options-development of consensus guidelines. Journal of the European Academy of Dermatology and Venereology 19 Suppl. 1 (2005) 25-33
11. Monroy-Ortiz C., and Castillo-España P. Plantas medicinales utilizadas en Morelos (2000), Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, México pp. 61-62
12. Murdan S. Enhancing the nail permeability of topically applied drugs. Expert Opinion on Drug Delivery 5 (2008) 1267-1282
13. Navarro V.M., García A., González M., Fuentes A., Avilés M., Ríos Y., Zepeda G., and Rojas M.G. Antifungal activities of nine traditional Mexican medicinal plants. Journal of Ethnopharmacology 87 (2003) 85-88
14. Nunley K.S., and Cornelius L. Current management of onychomycosis. The Journal of Hand Surgery 33 (2008) 1211-1214
15. Poulin Y., Thomas R., and Gupta A.K. Brief treatment guide for onychomycosis. Journal of Cutaneous Medicine and Surgery 10 Suppl. 2 (2006) S39-S43
16. Rigopoulos D., Katoulis A.C., Ioannides D., Georgala S., Kalogeromitros D., Bolbasis I., Karistinou A., Christofidou E., Polydorou D., Balkou P., Fragouli E., and Katsambas A.D. A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis. The British Journal of Dermatology 149 (2003) 151-156
17. Rippon J.W. Tratado de Micología Médica. 3ra ed. (1990), Interamericana McGraw-Hill, México Capítulo 8, pp. 186-202
18. Romero-Cerecero O., Rojas-Bribiesca M.G., Navarro V.M., Herrera-Arellano A., Zamilpa-Álvarez A., and Tortoriello J. Effectiveness and tolerability of a standardized extract from Ageratina pichinchensis on patients with tinea pedis. A double blind clinical trial. Planta Medica 72 (2006) 1257-1261
19. Romero-Cerecero O., Zamilpa A., Jiménez-Ferrer J.E., Rojas-Bribiesca M.G., Román-Ramos R., and Tortoriello J. Double-blind clinical trial for evaluating the effectiveness and tolerability of Ageratina pichinchensis extract on patients with mild to moderate onychomycosis. A comparative study with ciclopirox. Planta Medica 74 (2008) 1430-1435
20. Szepietowski, J.C., Reich, A., in press. For the National Quality of Life in Dermatology Group. Stigmatisation in onychomycosis patients: a population-based study. Mycoses.
21. Warshaw E.M., Fett D.D., Bloomfield H.E., Grill J.P., Nelson D.B., Quintero V., Carver S.M., Zielke G.R., and Lederle F.A. Pulse versus continuous terbinafine for onychomycosis: a randomized, double-blind, controlled trial. Journal of the American Academy of Dermatology 43 (2005) 578-584
22. Zurita E.M., and Zolla C. Enfermedades dermatológicas en la medicina tradicional de México. Boletín de la Oficina Sanitaria Panamericana 101 (1986) 339-344