Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity

Journal of Ethnopharmacology

Volumn 126, Issue 1, 2009, Pages 114-118

  Houël, Emeline ^a   Bertani, Stéphane ^b   Bourdy, Geneviève ^c   Deharo, Eric ^c   Jullian, Valérie ^c   Valentin, Alexis ^c   Chevalley, Séverine ^c   Stien, Didier ^a  

^a UNIVERSITÉ DES ANTILLES ET DE LA GUYANE   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c UMR 152 IRD Universite Paul Sabatier   (France)

Author keywords

Antimalarial activity; Cytotoxicity; Leaf tea; Quassia amara L.; Simalikalactone D; Simaroubaceae

Indexed keywords

ANTIMALARIAL AGENT; CYTOTOXIC AGENT; DICHLOROMETHANE; NEOQUASSIN; PICRASIN B; PICRASIN H; PICRASIN I; PICRASIN J; PLANT EXTRACT; QUASSIA AMARA EXTRACT; QUASSIN; QUASSINOID; SIMALIKALACTONE D; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG PURITY; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PLANT LEAF; PLASMODIUM FALCIPARUM; QUASSIA; QUASSIA AMARA; TEA; VERO CELL;

ANTIMALARIALS; BEVERAGES; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; MEDICINE, AFRICAN TRADITIONAL; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PLANT EXTRACTS; PLANT LEAVES; PLASMODIUM FALCIPARUM; QUASSIA; QUASSINS;

QUASSIA AMARA; SIMAROUBACEAE;

EID: 70349781657     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.07.037     Document Type: Article

References (20)

1. Apers S., Cimanga K., Van den Berghe D., Van Meenen E., Otshudi Longanga A., Foriers A., Vlietinck A., and Pieters L. Antiviral activity of simalikalactone D, a quassinoid from Quassia africana. Planta Medica 68 (2002) 20-24
2. Bedikian A.Y., Valdivieso M., and Bodey G.P. Initial clinical studies with bruceantin. Cancer Treatment Reports 63 (1979) 1843-1847
3. Benoit F., Valentin A., Pélissier Y., Diafouka F., Marion C., Kone-Bamba D., Koné M., Mallié M., Yapo A., and Bastide J.-M. In vitro antimalarial activity of vegetal extracts used in West African traditional medicine. American Journal of Tropical Medicine and Hygiene 54 (1996) 67-71
4. Bertani S., Bourdy G., Landau I., Robinson J.-C., Esterre P., and Deharo E. Evaluation of French Guiana traditional antimalarial remedies. Journal of Ethnopharmacology 98 (2005) 45-54
5. Bertani S., Houël E., Stien D., Chevolot L., Jullian V., Garavito G., Bourdy G., and Deharo E. Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae). Journal of Ethnopharmacology 108 (2006) 155-157
6. Bertani S., Houël E., Bourdy G., Stien D., Jullian V., Landau I., and Deharo E. Quassia amara L. (Simaroubaceae) leaf tea: effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation. Journal of Ethnopharmacology 111 (2007) 40-42
7. Cabral J.A., McChesney J.D., and Milhous W.K. A new antimalarial quassinoid from Simaba guianensis. Journal of Natural Products 56 (1993) 1954-1961
8. Chaud P., Paquet C., Huguet P., and Cottrelle B. Surveillance épidémiologique du paludisme en Guyane (2006), Institut de Veille Sanitaire Cayenne. http://www.invs.sante.fr/publications/2006/paludisme_guyane/paludisme_guyane.pdf 2-11-095765-5
9. Guo Z., Vangapandu S., Sindelar R.W., Walker L.A., and Sindelar R.D. Biologically active quassinoids and their chemistry: potential leads for drug design. Current Medicinal Chemistry 12 (2005) 173-190
10. Hikino H., Ohta T., and Takemoto T. Picrasins, simaroubolides of Japanese quassia tree Picrasma quassioides. Phytochemistry 14 (1975) 2473-2481
11. Kawada K., Kim M., and Watt D.S. A partial synthesis of picrasin B and Δ2-picrasin B. Tetrahedron Letters 30 (1989) 5985-5988
12. Kim M., Kawada K., Gross R.S., and Watt D.S. An enantioselective synthesis of (+)-picrasin B, (+)-Δ2-picrasin B, and (+)-quassin from the R-(-) enantiomer of the Wieland-Miescher ketone. Journal of Organic Chemistry 55 (1990) 504-511
13. Le Bras J., and Deloron P. In vitro study of drug sensitivity of Plasmodium falciparum: evaluation of a new semi-micro test. American Journal of Tropical Medicine and Hygiene 32 (1983) 447-451
14. Muhammad I., Bedir E., Khan S.I., Tekwani B.L., Khan I.A., Takamatsu S., Pelletier J., and Walker L.A. A new antimalarial quassinoid from Simaba orinocensis. Journal of Natural Products 67 (2004) 772-777
15. Muhammad I., and Samoylenko V. Antimalarial quassinoids: past, present and future. Expert Opinion on Drug Discovery 2 (2007) 1065-1084
16. O'Neill M.J., Bray D.H., Boardman P., Phillipson J.D., Warhust D.C., Peters W., and Suffness M. Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids. Antimicrobial Agents and Chemotherapy 30 (1986) 101-104
17. Ozeki A., Hitotsuyanagi Y., Hashimoto E., Itokawa H., Takeya K., and de Mello Alves S. Cytotoxic quassinoids from Simaba cedron. Journal of Natural Products 61 (1998) 776-780
18. Valenta Z., Papadopoulos S., and Podesva C. Quassin and neoquassin. Tetrahedron 15 (1961) 100-110
19. Vigneron M., Deparis X., Deharo E., and Bourdy G. Antimalarial remedies in French Guiana: a knowledge attitudes and practices study. Journal of Ethnopharmacology 98 (2005) 351-360
20. Xu Z., Chang F.-R., Wang H.-K., Kashiwada Y., McPhail A.T., Bastow K.F., Tachibana Y., Cosentino M., and Lee K.H. Anti-HIV agents 45 and antitumor agents 205. Two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridana. Journal of Natural Products 63 (2000) 1712-1715