Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors

Journal of Receptors and Signal Transduction

Volumn 29, Issue 3-4, 2009, Pages 173-181

  Fleming, Matthew R ^a   Kaczmarek, Leonard K ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Channel protein interactions; KNA Channels; Label free screening; Potassium channels; Slack

Indexed keywords

G PROTEIN COUPLED RECEPTOR; POTASSIUM CHANNEL; SLACK B CHANNEL; UNCLASSIFIED DRUG; CARBACHOL; CHOLINERGIC RECEPTOR STIMULATING AGENT; KCNT2 PROTEIN, HUMAN; MUSCARINIC RECEPTOR;

ARTICLE; CELL MEMBRANE; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MODULATION; OPTICAL BIOSENSOR; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; CELL LINE; DRUG EFFECT; DRUG POTENTIATION; GENETIC PROCEDURES; METABOLISM; PHYSIOLOGY;

BIOSENSING TECHNIQUES; CARBACHOL; CELL LINE; CHOLINERGIC AGONISTS; HUMANS; POTASSIUM CHANNELS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION;

EID: 70349781297     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.1080/10799890903056883     Document Type: Article

References (39)

1. Hille B. Ion Channels of Excitable Membranes. Sunderland, MA: Sinauer Associates, 1991.
2. Levitan IB. Signaling protein complexes associated with neuronal ion channels. Nat Neurosci 2006;9(3): 305-310
3. Wong W, Scott JD.AKAP signalling complexes: Focal points in space and time.Nat Rev Mol Cell Biol 2004;5(12):959-970
4. Fanger CM, et al. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. J Biol Chem 1999;274(9):5746-5754
5. Xia XM, et al. Mechanism of calcium gating in small- conductance calcium-activated potassium channels. Nature 1998;395(6701):503-507
6. Kaczmarek LK. Non-conducting functions of voltage-gated ion channels. Nat Rev Neurosci 2006;7(10):761-771
7. Fang Y, et al. Resonant waveguide grating biosensor for living cell sensing. Biophys J 2006;91(5):1925-1940
8. Fang Y, Li G, Ferrie AM. Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells. J Pharmacol Toxicol Methods 2007;55(3):314-322
9. Fang Y. Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Dev Technol 2006;4(5):583-595
10. Fleming MR, Brown MR, Li F, Gao A, Kaczmarek LK. Use of label-free optical biosensors to detect putative potassium channel interactions with cytoplasmic proteins in intact cells. Soc Neurosci Abstr 2008;430.19.
11. Santi CM, et al. Opposite regulation of Slick and Slack K + channels by neuromodulators. J Neurosci 2006;26(19):5059-5068
12. Jeng CJ, Chang CC, Tang CY. Differential localization of rat Eag1 and Eag2 K + channels in hippocampal neurons. Neuroreport 2005;16(3):229-233
13. Wang Z, Wilson GF, Griffi th LC. Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel. J Biol Chem 2002;277(27):24022-24029
14. Hegle AP, Marble DD, Wilson GF. A voltage-driven switch for ion-independent signaling by ether-a-go-go K + channels. Proc Natl Acad Sci U S A 2006;103(8):2886-2891
15. Sun XX, et al. The eag potassium channel binds and locally activates calcium/calmodulin-dependent protein kinase II. J Biol Chem 2004;279(11):10206- 10214
16. Chin D, Means AR. Calmodulin: A prototypical calcium sensor. Trends Cell Biol 2000;10(8):322-328
17. Budde T, Meuth S, Pape HC. Calcium-dependent inactivation of neuronal calcium channels. Nat Rev Neurosci 2002;3(11):873-883
18. Wang J, et al. Simultaneous binding of two protein kinases to a calcium- dependent potassium channel. J Neurosci 1999;19(10):RC4.
19. Schopperle WM, et al. Slob, a novel protein that interacts with the Slowpoke calcium-dependent potassium channel. Neuron 1998;20(3):565-573
20. Xia X, et al. dSLo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels. J Neurosci 1998;18(7):2360-2369
21. Zhou Y, et al. A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals. Neuron 1999;22(4):809-818
22. An WF, et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature 2000;403(6769):553-556
23. Buxbaum JD, et al. Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med 1998;4(10):1177-1181
24. Carrion AM, et al. DREAM is a Ca2 + -regulated transcriptional repressor. Nature 1999;398(6722):80-84
25. Steiner H, Haass C. Intramembrane proteolysis by presenilins. Nat Rev Mol Cell Biol 2000;1(3):217-224
26. Reuveny E, et al. Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature 1994;370(6485):143-146
27. Dolphin AC. G protein modulation of voltage-gated calcium channels. Pharmacol Rev 2003;55(4):607-627
28. Kameyama M, et al. Intracellular Na + activates a K + channel in mammalian cardiac cells. Nature 1984;309(5966):354-356
29. Bhattacharjee A, Kaczmarek LK. For K + channels, Na + is the new Ca2 + . Trends Neurosci 2005;28(8):422-428
30. Joiner WJ, et al. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nat Neurosci 1998;1(6):462-469
31. Yuan A, et al. The sodium-activated potassium channel is encoded by a member of the Slo gene family [see comment]. Neuron 2003;37(5):765-773
32. Bhattacharjee A, et al.Slick (Slo2.1), a rapidly-gating sodiumactivated potassium channel inhibited by ATP. J Neurosci 2003;23(37):11681-11691
33. Jiang Y, et al.Structure of the RCK domain from the E. coli K + channel and demonstration of its presence in the human BK channel. Neuron 2001;29(3):593-601.
34. Tomita S, Nicoll RA, Bredt DS. PDZ protein interactions regulating glutamate receptor function and plasticity. J Cell Biol 2001;153(5):F19-24.
35. Brown MR, et al. Amino-termini isoforms of the Slack K + channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation. J Physiol 2008;586(Pt 21):5161-5179
36. Yang B, Desai R, Kaczmarek LK. Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons. J Neurosci 2007;27(10):2617-2627
37. Fleming MR, Yan Y, Lam TT, Gulcicek EE, Sigworth FJ, Nairn AC, Kaczmarek LK,Regulation of sodium activated (KNa) channels by phosphorylation. Soc Neurosci Abstr. 2008;430.19.
38. Lee PH, et al. Evaluation of dynamic mass redistribution technology for pharmacological studies of recombinant and endogenously expressed g protein-coupled receptors. Assay Drug Dev Technol 2008;6(1):83-94.
39. Uchino S, et al. Slo2 sodium-activated K + channels bind to the PDZ domain of PSD-95. Biochem Biophys Res Commun 2003;310(4):1140-1147