Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4616-4621

  El Aouad, Noureddine ^a   Berenguer, Inmaculada ^a   Romero, Vanessa ^a   Marín, Paloma ^a   Serrano, Ángel ^a   Andujar, Sebastián ^b,c   Suvire, Fernando ^b   Bermejo, Almudena ^a,d   Ivorra, M Dolores ^a   Enriz, Ricardo D ^b,c   Cabedo, Nuria ^a,e   Cortes, Diego ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^d INSTITUTO VALENCIANO DE INVESTIGACIONES AGRARIAS IVIA   (Spain)

^e UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

1 Halogenated benzyl 7 chloro 6 hydroxy tetrahydroisoquinolines; Binding; Dopamine receptors; Dopamine uptake; Structure activity relationships

Indexed keywords

1 (2' BROMOBENZYL) 6 CHLORO 7 HYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (2' BROMOBENZYL) 6 CHLORO 7 HYDROXY N METHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (2' BROMOBENZYL) 6 CHLORO 7 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (2' BROMOBENZYL) 6 CHLORO 7 METHOXY N METHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (2',4' DICHLOROBENZYL) 6 CHLORO 7 HYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (2',4' DICHLOROBENZYL) 6 CHLORO 7 HYDROXY N METHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (2',4' DICHLOROBENZYL) 6 CHLORO 7 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (2',4' DICHLOROBENZYL) 6 CHLORO 7 METHOXY N METHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE UPTAKE; DRUG SYNTHESIS; FEMALE; HALOGENATION; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; SYNAPTOSOME;

ANIMALS; FEMALE; HALOGENATION; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 70349780436     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.033     Document Type: Article

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