The inhibitory effect of Gynostemma pentaphyllum on MCP-1 and type I procollagen expression in rat hepatic stellate cells

Journal of Ethnopharmacology

Volumn 126, Issue 1, 2009, Pages 42-49

  Chen, Ming Ho ^a,b,c   Wang, Qwa Fun ^b,c   Chen, Lih Geeng ^b   Shee, Jia Jen ^d   Chen, Jung Chou ^c   Chen, Ke Yu ^b   Chen, Shu Hsin ^b   Su, Jyan Gwo J ^b   Liu, Yi Wen ^b  

^a CHIA YI CHRISTIAN HOSPITAL   (Taiwan)

^b NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Anti proliferation; Gynostemma pentaphyllum; Gypenosides; Monocyte chemoattractant protein 1; Rat hepatic stellate cells; Type I procollagen

Indexed keywords

BUTANOL; CARBON TETRACHLORIDE; CYTOKINE; DRUG VEHICLE; GYNOSTEMMA PENTAPHYLLUM EXTRACT; GYPENOSIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; PROCOLLAGEN; RAPAMYCIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GYNOSTEMMA PENTAPHYLLUM; HEPATITIS; LIVER CELL; LIVER FIBROSIS; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL; TRADITIONAL MEDICINE; WESTERN BLOTTING;

ANIMALS; CELL PROLIFERATION; CHEMOKINE CCL2; COLLAGEN TYPE I; CYTOKINES; DRUGS, CHINESE HERBAL; GENE EXPRESSION; GYNOSTEMMA; HEPATIC STELLATE CELLS; MALE; PLANT EXTRACTS; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY;

GYNOSTEMMA PENTAPHYLLUM; RATTUS;

EID: 70349777268     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.08.012     Document Type: Article

References (30)

1. Aktan F., Henness S., Roufogalis B.D., and Ammit A.J. Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-kappaB-mediated iNOS protein expression. Nitric Oxide 8 (2003) 235-242
2. Bataller R., and Brenner D.A. Liver fibrosis. Journal of Clinical Investigation 115 (2005) 209-218
3. Bedossa P., and Paradis V. Liver extracellular matrix in health and disease. The Journal of Pathology 200 (2003) 504-515
4. Chen J.C., Chung J.G., and Chen L.D. Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells. Cytobios 100 (1999) 37-48
5. 4 in rats. American Journal of Chinese Medicine 28 (2000) 175-185
6. Chen M.H., Chen S.H., Wang Q.F., Chen J.C., Chang D.C., Hsu S.L., Chen C.H., Sheue C.R., and Liu Y.W. The molecular mechanism of gypenosides-induced G(1) growth arrest of rat hepatic stellate cells. Journal of Ethnopharmacology 117 (2008) 309-317
7. Chen M.H., Wang Q.F., Hsu S.L., Hsu L.I., Hsieh H.Y., Wang W.C., Liu Y.W., Chen S.H., and Chen J.C. The anti-proliferation effect of gypenosides in culture rat hepatic stellate cell. Journal of Integrated Chinese and Western Medicine 9 (2007) 1-10
8. Cui J., Eneroth P., and Bruhn J.G. Gynostemma pentaphyllum: identification of major sapogenins and differentiation from Panax species. European Journal of Pharmaceutical Sciences 8 (1999) 187-191
9. Cui J.F., Garle M., Lund E., Bjorkhem I., and Eneroth P. Analysis of ginsenosides by chromatography and mass spectrometry: release of 20 S-protopanaxadiol and 20 S-protopanaxatriol for quantitation. Analytical Biochemistry 210 (1993) 411-417
10. Friedman S.L. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. New England Journal of Medicine 328 (1993) 1828-1835
11. Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. Journal of Biological Chemistry 275 (2000) 2247-2250
12. Friedman S.L., Roll F.J., Boyles J., and Bissell D.M. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proceedings of the National Academy of Sciences of the United States of America 82 (1985) 8681-8685
13. Gabele E., Reif S., Tsukada S., Bataller R., Yata Y., Morris T., Schrum L.W., Brenner D.A., and Rippe R.A. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Journal of Biological Chemistry 280 (2005) 13374-13382
14. Hou J., Liu S., Ma Z., Lang X., Wang J., Wang J., and Liang Z. Effects of Gynostemma pentaphyllum makino on the immunological function of cancer patients. Journal of Traditional Chinese Medicine 11 (1991) 47-52
15. Huang T.H., Li Y., Razmovski-Naumovski V., Tran V.H., Li G.Q., Duke C.C., and Roufogalis B.D. Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway. Journal of Biomedical Science 13 (2006) 535-548
16. Ikeda K., Wakahara T., Wang Y.Q., Kadoya H., Kawada N., and Kaneda K. In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology 29 (1999) 1760-1767
17. Kao T.H., Huang S.C., Inbaraj B.S., and Chen B.H. Determination of flavonoids and saponins in Gynostemma pentaphyllum (Thunb.) Makino by liquid chromatography-mass spectrometry. Analytica Chimica Acta 626 (2008) 200-211
18. Kawada N., Seki S., Inoue M., and Kuroki T. Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 27 (1998) 1265-1274
19. Kruglov E.A., Nathanson R.A., Nguyen T., and Dranoff J.A. Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts. American Journal of Physiology. Gastrointestinal and Liver Physiology 290 (2006) G765-G771
20. Kuwahara M., Kawanishi F., Komiya T., and Oshio H. Dammarane saponins of Gynostemma pentaphyllum MAKINO and isolation of malonylginsenosides-Rb1, -Rd, and malonylgypenoside V. Chemical & Pharmaceutical Bulletin 37 (1989) 135-139
21. la Cour B., Molgaard P., and Yi Z. Traditional Chinese medicine in treatment of hyperlipidaemia. Journal of Ethnopharmacology 46 (1995) 125-129
22. Lin C.C., Huang P.C., and Lin J.M. Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum. American Journal of Chinese Medicine 28 (2000) 87-96
23. Lin J.M., Lin C.C., Chiu H.F., Yang J.J., and Lee S.G. Evaluation of the anti-inflammatory and liver-protective effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats. American Journal of Chinese Medicine 21 (1993) 59-69
24. Marra F. Chemokines in liver inflammation and fibrosis. Frontiers in Bioscience 7 (2002) d1899-d1914
25. Marra F., Arrighi M.C., Fazi M., Caligiuri A., Pinzani M., Romanelli R.G., Efsen E., Laffi G., and Gentilini P. Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology 30 (1999) 951-958
26. Megalli S., Aktan F., Davies N.M., and Roufogalis B.D. Phytopreventative anti-hyperlipidemic effects of Gynostemma pentaphyllum in rats. Journal of Pharmacy & Pharmaceutical Sciences 8 (2005) 507-515
27. Tsukamoto H. Cytokine regulation of hepatic stellate cells in liver fibrosis. Alcoholism-Clinical and Experimental Research 23 (1999) 911-916
28. Wang Q.F., Chen J.C., Hsieh S.J., Cheng C.C., and Hsu S.L. Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells. Cancer Letters 183 (2002) 169-178
29. Wang Q.F., Chiang C.W., Wu C.C., Cheng C.C., Hsieh S.J., Chen J.C., Hsieh Y.C., and Hsu S.L. Gypenosides induce apoptosis in human hepatoma Huh-7 cells through a calcium/reactive oxygen species-dependent mitochondrial pathway. Planta Medica 73 (2007) 535-544
30. Yin F., Zhang Y.N., Yang Z.Y., and Hu L.H. Nine new dammarane saponins from Gynostemma pentaphyllum. Chemistry & Biodiversity 3 (2006) 771-782