Relationship between intracranial hemodynamics and microdialysis markers of energy metabolism and glutamate-glutamine turnover in patients with subarachnoid hemorrhage: Clinical article

Journal of Neurosurgery

Volumn 111, Issue 5, 2009, Pages 910-915

  Samuelsson, Carolina ^a   Howells, Timothy ^a   Kumlien, Eva ^b   Enblad, Per ^a   Hillered, Lars ^a   Ronne Engström, Elisabeth ^a  

^a Department of Neurosurgery Unit ^*  (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Glutamate; Glutamine; Intracranial pressure; Lactate; Microdialysis; Pyruvate

Indexed keywords

GLUTAMIC ACID; GLUTAMINE; LACTIC ACID; PYRUVIC ACID; BIOLOGICAL MARKER;

ADULT; AMINO ACID SYNTHESIS; ARTICLE; ASTROCYTE; BRAIN; BRAIN LEVEL; BRAIN PERFUSION; BRAIN TISSUE; CEREBROSPINAL FLUID DRAINAGE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATIONAL STUDY; ENERGY METABOLISM; FEMALE; HEMODYNAMICS; HUMAN; INTENSIVE CARE UNIT; INTRACRANIAL PRESSURE; MALE; MEAN ARTERIAL PRESSURE; MICRODIALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECORDING; SUBARACHNOID HEMORRHAGE; AGED; BLOOD PRESSURE; BRAIN CIRCULATION; INTENSIVE CARE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; RETROSPECTIVE STUDY;

AGED; BIOLOGICAL MARKERS; BLOOD PRESSURE; CEREBROVASCULAR CIRCULATION; ENERGY METABOLISM; FEMALE; GLUTAMIC ACID; GLUTAMINE; HEMODYNAMICS; HUMANS; INTENSIVE CARE; INTRACRANIAL PRESSURE; LACTIC ACID; MALE; MICRODIALYSIS; MIDDLE AGED; PROSPECTIVE STUDIES; PYRUVIC ACID; RETROSPECTIVE STUDIES; SUBARACHNOID HEMORRHAGE;

EID: 70349774301     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2008.8.JNS0889     Document Type: Article

References (20)

1. Cesarini KG, Enblad P, Ronne-Engstrom E, Marklund N, Salci K, Nilsson P, et al: Early cerebral hyperglycolysis after subarachnoid haemorrhage correlates with favourable outcome. Acta Neurochir 144:1121-1131, 2002 (Pubitemid 35352141)
2. Heuer GG, Smith MJ, Elliott JP, Winn HR, LeRoux PD: Relationship between intracranial pressure and other clinical variables in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 101:408-416, 2004
3. Hillered L, Hallstrom A, Segersvard S, Persson L, Ungerstedt U: Dynamics of extracellular metabolites in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis. J Cereb Blood Flow Metab 9:607-616, 1989 (Pubitemid 19239480)
4. Hillered L, Vespa PM, Hovda DA: Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis. J Neurotrauma 22:3-41, 2005
5. Howells T, Elf K, Jones PA, Ronne-Engstrom E, Piper I, Nilsson P, et al: Pressure reactivity as a guide in the treatment of cerebral perfusion pressure in patients with brain trauma. J Neurosurg 102:311-317, 2005 (Pubitemid 43194082)
6. Kanamori K, Ross BD: Quantitative determination of extracellular glutamine concentration in rat brain, and its elevation in vivo by system A transport inhibitor, alpha-(methylamino) isobutyrate. J Neurochem 90:203-210, 2004 (Pubitemid 38879174)
7. Magistretti PJ, Pellerin L: Astrocytes couple synaptic activity to glucose utilization in the brain. News Physiol Sci 14:177-182, 1999
8. Richards DA, Tolias CM, Sgouros S, Bowery NG: Extracellular glutamine to glutamate ratio may predict outcome in the injured brain: a clinical microdialysis study in children. Pharmacol Res 48:101-109, 2003 (Pubitemid 36593365)
9. Ronne-Engstrom E, Cesarini KG, Enblad P, Hesselager G, Marklund N, Nilsson P, et al: Intracerebral microdialysis in neurointensive care: the use of urea as an endogenous reference compound. J Neurosurg 94:397-402, 2001 (Pubitemid 32786017)
10. Ronne Engstrom E, Hillered L, Enblad P, Karlsson T: Cerebral interstitial levels of glutamate and glutamine after intravenous administration of nutritional amino acids in neurointensive care patients. Neurosci Lett 384:7-10, 2005 (Pubitemid 40826608)
11. Ryttlefors M, Howells T, Nilsson P, Ronne-Engstrom E, Enblad P: Secondary insults in subarachnoid hemorrhage: occurrence and impact on outcome and clinical deterioration. Neurosurgery 61:704-705, 2007 (Pubitemid 350073246)
12. Samuelsson C, Hillered L, Enblad P, Ronne-Engstrom E: Microdialysis patterns in subarachnoid hemorrhage patients with focus on ischemic events and brain interstitial glutamine levels. Acta Neurochir (Wien) [epub ahead of print], 2009
13. Samuelsson C, Hillered L, Zetterling M, Enblad P, Hesselager G, Ryttlefors M, et al: Cerebral glutamine and glutamate levels in relation to compromised energy metabolism: a microdialysis study in subarachnoid hemorrhage patients. J Cereb Blood Flow Metab 27:1309-1317, 2007 (Pubitemid 46985347)
14. Sarrafzadeh AS, Thomale UW, Haux D, Unterberg AW: Cerebral metabolism and intracranial hypertension in high grade aneurysmal subarachnoid haemorrhage patients. Acta Neurochir Suppl 95:89-92, 2005
15. Shen J, Petersen KF, Behar KL, Brown P, Nixon TW, Mason GF, et al: Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proc Natl Acad Sci U S A 96:8235-8240, 1999 (Pubitemid 29328438)
16. Teasdale GM, Drake CG, Hunt W, Kassell N, Sano K, Pertuiset B, et al: A universal subarachnoid hemorrhage scale: report of a committee of the World Federation of Neurosurgical Societies. J Neurol Neurosurg Psychiatry 51:1457, 1988
17. Tofteng F, Hauerberg J, Hansen BA, Pedersen CB, Jorgensen L, Larsen FS: Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 26:21-27, 2006 (Pubitemid 41818066)
18. Wilkinson HA: Intracranial pressure, in Youmans JR (ed): Neurological Surgery, ed 3. Philadelphia: WB Saunders Company, 1990, pp 661-694
19. Xu GY, McAdoo DJ, Hughes MG, Robak G, de Castro R Jr: Considerations in the determination by microdialysis of resting extracellular amino acid concentrations and release upon spinal cord injury. Neuroscience 86:1011-1021, 1998 (Pubitemid 28298755)
20. Yi JH, Hazell AS: Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem Int 48:394-403, 2006 (Pubitemid 43327279)