메뉴 건너뛰기




Volumn 11, Issue 2, 2009, Pages 101-105

A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis

Author keywords

Genetic variant; Mitochondria; Mitochondrial membrane potential; Mitochondrial uncoupling protein; Multiple sclerosis

Indexed keywords

GENOMIC DNA; MATRIX METALLOPROTEINASE; MITOCHONDRIAL PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 4; CARRIER PROTEIN; SLC25A27 PROTEIN, HUMAN;

EID: 70349773947     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12017-009-8071-4     Document Type: Article
Times cited : (13)

References (21)
  • 1
    • 0035195969 scopus 로고    scopus 로고
    • The prevalence of multiple sclerosis, distribution of clinical forms of the disease and functional status of patients in Csongrád County, Hungary
    • DOI 10.1159/000050806
    • K Bencsik C Rajda J Fuvesi P Klivenyi T Jardanhazy M Torok L Vecsei 2001 The prevalence of multiple sclerosis, distribution of clinical forms of the disease and functional status of patients in Csongrad County, Hungary European Neurology 46 206 209 11721128 10.1159/000050806 1:STN:280:DC%2BD3MnnsFSjug%3D%3D (Pubitemid 33135795)
    • (2001) European Neurology , vol.46 , Issue.4 , pp. 206-209
    • Bencsik, K.1    Rajda, C.2    Fuvesi, J.3    Klivenyi, P.4    Jardanhazy, T.5    Torok, M.6    Vecsei, L.7
  • 2
    • 0344197683 scopus 로고    scopus 로고
    • Alpha-tocopherol and NADPH in the erythrocytes and plasma of multiple sclerosis patients: Effect of interferon-β-1b treatment
    • DOI 10.1159/000073862
    • E Karg P Klivenyi K Bencsik S Turi L Vecsei 2003 Alpha-tocopherol and NADPH in the erythrocytes and plasma of multiple sclerosis patients. Effect of interferon-beta-1b treatment European Neurology 50 215 219 14634265 10.1159/000073862 1:CAS:528:DC%2BD3sXpt1WgsLs%3D (Pubitemid 37499936)
    • (2003) European Neurology , vol.50 , Issue.4 , pp. 215-219
    • Karg, E.1    Klivenyi, P.2    Bencsik, K.3    Turi, S.4    Vecsei, L.5
  • 3
    • 0026570540 scopus 로고
    • Insulin-like growth factor i gene expression is induced in astrocytes during experimental demyelination
    • 1371885 10.1073/pnas.89.5.1894 1:CAS:528:DyaK38Xhs1Oju7k%3D
    • S Komoly LD Hudson HD Webster CA Bondy 1992 Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination Proceedings of the National Academy of Sciences of the United States of America 89 1894 1898 1371885 10.1073/pnas.89.5.1894 1:CAS:528:DyaK38Xhs1Oju7k%3D
    • (1992) Proceedings of the National Academy of Sciences of the United States of America , vol.89 , pp. 1894-1898
    • Komoly, S.1    Hudson, L.D.2    Webster, H.D.3    Bondy, C.A.4
  • 4
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDDS)
    • JF Kurtzke 1993 Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDDS) Neurology 33 1442 1452
    • (1993) Neurology , vol.33 , pp. 1442-1452
    • Kurtzke, J.F.1
  • 5
    • 33745230018 scopus 로고    scopus 로고
    • Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress
    • DOI 10.1385/NMM:8:3:389, PII N83389
    • D Liu SL Chan NC de Souza-Pinto JR Slevin RP Wersto M Zhan K Mustafa R de Cabo MP Mattson 2006 Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress Neuromolecular Medicine 8 389 414 16775390 10.1385/NMM:8:3:389 1:CAS:528:DC%2BD28Xls1ShsLs%3D (Pubitemid 43918160)
    • (2006) NeuroMolecular Medicine , vol.8 , Issue.3 , pp. 389-414
    • Liu, D.1    Chan, S.L.2    De Souza-Pinto, N.C.3    Slevin Jr., J.R.4    Wersto, R.P.5    Zhan, M.6    Mustafa, K.7    De Cabo, R.8    Mattson, M.P.9
  • 6
    • 0037427415 scopus 로고    scopus 로고
    • Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death
    • DOI 10.1016/S0006-291X(03)00627-2
    • MP Mattson D Liu 2003 Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death Biochemical and Biophysical Research Communications 9 539 549 10.1016/S0006-291X(03)00627-2 (Pubitemid 36506527)
    • (2003) Biochemical and Biophysical Research Communications , vol.304 , Issue.3 , pp. 539-549
    • Mattson, M.P.1    Liu, D.2
  • 7
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
    • DOI 10.1002/ana.1032
    • WI McDonald A Compston G Edan D Goodkin HP Hartung FD Lublin HF McFarland DW Paty CH Polman SC Reingold M Sandberg-Wollheim W Sibley A Thompson S van den Noort BY Weinshenker JS Wolinsky 2001 Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis Annals of Neurology 50 121 127 11456302 10.1002/ana.1032 1:STN:280:DC%2BD38%2FitFOhug%3D%3D (Pubitemid 32591472)
    • (2001) Annals of Neurology , vol.50 , Issue.1 , pp. 121-127
    • Buckley, C.1    Douek, D.2    Newsom-Davis, J.3    Vincent, A.4    Willcox, N.5
  • 8
    • 0025741072 scopus 로고
    • Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: Concerted action guidelines
    • 10.1136/jnnp.54.8.683 1:STN:280:DyaK38%2FksVGksw%3D%3D
    • DH Miller F Barkof I Berry L Kappos S Scotti AJ Thompson 1991 Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: Concerted action guidelines Journal of Neurology, Neurosurgery and Psychiatry 54 683 688 10.1136/jnnp.54.8.683 1:STN:280:DyaK38%2FksVGksw%3D%3D
    • (1991) Journal of Neurology, Neurosurgery and Psychiatry , vol.54 , pp. 683-688
    • Miller, D.H.1    Barkof, F.2    Berry, I.3    Kappos, L.4    Scotti, S.5    Thompson, A.J.6
  • 9
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • 3344216 10.1093/nar/16.3.1215 1:CAS:528:DyaL1cXhsVKlsrs%3D
    • SA Miller DD Dykes HF Polesky 1988 A simple salting out procedure for extracting DNA from human nucleated cells Nucleic Acids Research 16 1215 1218 3344216 10.1093/nar/16.3.1215 1:CAS:528:DyaL1cXhsVKlsrs%3D
    • (1988) Nucleic Acids Research , vol.16 , pp. 1215-1218
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 10
    • 34249081073 scopus 로고    scopus 로고
    • UCP2 and mitochondrial haplogroups as a multiple sclerosis risk factor
    • 17463068 1:CAS:528:DC%2BD2sXmvVOiu7g%3D
    • D Otaegui A Saenz J Ruiz-Martinez J Olaskoaga A López de Munain 2007 UCP2 and mitochondrial haplogroups as a multiple sclerosis risk factor Multiple Sclerosis 13 4 454 458 17463068 1:CAS:528:DC%2BD2sXmvVOiu7g%3D
    • (2007) Multiple Sclerosis , vol.13 , Issue.4 , pp. 454-458
    • Otaegui, D.1    Saenz, A.2    Ruiz-Martinez, J.3    Olaskoaga, J.4    López De Munai, A.5
  • 11
    • 0020686503 scopus 로고
    • New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
    • DOI 10.1002/ana.410130302
    • CM Poser DW Paty L Scheimberg WI McDonald FA Davis GC Ebers KP Johnson WA Sibley DH Silberberg WW Tourtellotte 1983 New diagnostic criteria for multiple sclerosis: Guidelines for research protocols Annals of Neurology 13 227 231 6847134 10.1002/ana.410130302 1:STN:280:DyaL3s3gt1OgtQ%3D%3D (Pubitemid 13158528)
    • (1983) Annals of Neurology , vol.13 , Issue.3 , pp. 227-231
    • Poser, C.M.1    Paty, D.W.2    Scheinberg, L.3
  • 12
    • 33751075727 scopus 로고    scopus 로고
    • Pathomechanism of leukoaraiosis: A molecular bridge between the genetic, biochemical, and clinical processes (a mitochondrial hypothesis)
    • DOI 10.1385/NMM:9:1:21, PII NMM9121
    • Z Szolnoki 2007 Pathomechanism of leukoaraiosis: Molecular bridge between the genetic, biochemical, and clinical processes (a mitochondrial hypothesis) Neuromolecular Medicine 9 21 33 17114822 10.1385/NMM:9:1:21 1:CAS:528: DC%2BD2sXot1Oms78%3D (Pubitemid 44772273)
    • (2007) NeuroMolecular Medicine , vol.9 , Issue.1 , pp. 21-34
    • Szolnoki, Z.1
  • 13
    • 35348826108 scopus 로고    scopus 로고
    • A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: Gene-environmental interactions behind vascular white matter demyelinization
    • DOI 10.1007/s12031-007-0062-z
    • Z Szolnoki A Kondacs Y Mandi F Somogyvari 2007 A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: Gene-environmental interactions behind vascular white matter demyelinization Journal of Molecular Neuroscience 33 173 179 17917076 10.1007/s12031-007-0062-z 1:CAS:528:DC%2BD2sXhtFyit7vN (Pubitemid 47574940)
    • (2007) Journal of Molecular Neuroscience , vol.33 , Issue.2 , pp. 173-179
    • Szolnoki, Z.1    Kondacs, A.2    Mandi, Y.3    Somogyvari, F.4
  • 14
    • 36949034307 scopus 로고    scopus 로고
    • A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: The janus face of the kinesin light-chain 1 56836CC genetic variant
    • DOI 10.1007/s12017-007-8014-x
    • Z Szolnoki A Kondacs Y Mandi F Somogyvari 2007 A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: The janus face of the kinesin light-chain 1 56836CC genetic variant Neuromolecular Medicine 9 335 339 17999208 10.1007/s12017-007-8014-x 1:CAS:528:DC%2BD2sXhsVWitrbJ (Pubitemid 350242637)
    • (2007) NeuroMolecular Medicine , vol.9 , Issue.4 , pp. 335-339
    • Szolnoki, Z.1    Kondacs, A.2    Mandi, Y.3    Somogyvari, F.4
  • 16
    • 0034075237 scopus 로고    scopus 로고
    • Isolated demyelinating syndromes: Comparison of different MR imaging criteria to predict conversion clinically definite multiple sclerosis
    • 10782781
    • M Tintoré A Rovira MJ Martinez, et al. 2000 Isolated demyelinating syndromes: Comparison of different MR imaging criteria to predict conversion clinically definite multiple sclerosis American Journal of Neuroradiology 21 702 706 10782781
    • (2000) American Journal of Neuroradiology , vol.21 , pp. 702-706
    • Tintoré, M.1    Rovira, A.2    Martinez, M.J.3
  • 18
    • 33646508138 scopus 로고    scopus 로고
    • Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis
    • 16651623 10.2353/ajpath.2006.051069 1:CAS:528:DC%2BD28XkvF2nt7g%3D
    • S Vogler J Pahnke S Rousset D Ricquier H Moch B Miroux SM Ibrahim 2006 Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis American Journal of Pathology 168 5 1570 1575 16651623 10.2353/ajpath.2006.051069 1:CAS:528:DC%2BD28XkvF2nt7g%3D
    • (2006) American Journal of Pathology , vol.168 , Issue.5 , pp. 1570-1575
    • Vogler, S.1    Pahnke, J.2    Rousset, S.3    Ricquier, D.4    Moch, H.5    Miroux, B.6    Ibrahim, S.M.7
  • 20
    • 34250354410 scopus 로고    scopus 로고
    • Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects
    • Yoon, Y., Park, B. L., Cha, M. H., Kim, K. S., Cheong, H. S., Choi, Y. H., et al. (2007). Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects. Biochemical and Biophysical Research Communications, 359(3), 451-456.
    • (2007) Biochemical and Biophysical Research Communications , vol.359 , Issue.3 , pp. 451-456
    • Yoon, Y.1    Park, L.B.2    Cha, H.M.3    Kim, S.K.4    Cheong, S.H.5    Choi, H.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.