메뉴 건너뛰기




Volumn 33, Issue 2, 2007, Pages 173-179

A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: Gene-environmental interactions behind vascular white matter demyelinization

Author keywords

Cytoskeleton; Genetic variants; Kinesin; Leukoaraiosis; White matter damage

Indexed keywords

KINESIN; KINESIN LIGHT CHAIN 1; MOLECULAR MOTOR; UNCLASSIFIED DRUG;

EID: 35348826108     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-007-0062-z     Document Type: Article
Times cited : (14)

References (40)
  • 1
    • 0029132704 scopus 로고
    • Ischemic delayed neuronal death. A mitochondrial hypothesis
    • Abe, K., Aoki, M., Kawagoe, J., Yoshida, T., Hattori, A., Kogure, K., et al. (1995). Ischemic delayed neuronal death. A mitochondrial hypothesis. Stroke, 26, 1478-1489.
    • (1995) Stroke , vol.26 , pp. 1478-1489
    • Abe, K.1    Aoki, M.2    Kawagoe, J.3    Yoshida, T.4    Hattori, A.5    Kogure, K.6
  • 2
    • 0031711978 scopus 로고    scopus 로고
    • Are genetic factors important in the aetiology of leukoaraiosis? Results from a memory clinic population
    • Amar, K., Macgowan, S., Wilcock, G., Lewis, T., & Scott, M. (1998). Are genetic factors important in the aetiology of leukoaraiosis? Results from a memory clinic population. International Journal of Geriatric Psychiatry, 13, 585-590.
    • (1998) International Journal of Geriatric Psychiatry , vol.13 , pp. 585-590
    • Amar, K.1    Macgowan, S.2    Wilcock, G.3    Lewis, T.4    Scott, M.5
  • 3
    • 33748463827 scopus 로고    scopus 로고
    • Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    • Basile, A. M., Pantoni, L., Pracucci, G., Asplund, K., Chabriat, H., Erkinjuntti, T., et al. (2006). Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study. Cerebrovascular Diseases, 2, 315-322.
    • (2006) Cerebrovascular Diseases , vol.2 , pp. 315-322
    • Basile, A.M.1    Pantoni, L.2    Pracucci, G.3    Asplund, K.4    Chabriat, H.5    Erkinjuntti, T.6
  • 4
    • 34249790312 scopus 로고    scopus 로고
    • Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well
    • Brown, W. R., Moody, D. M., Thore, C. R., Challa, V. R., & Anstrom, J. A. (2007) Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well. Journal of the Neurological Sciences, 257, 62-66.
    • (2007) Journal of the Neurological Sciences , vol.257 , pp. 62-66
    • Brown, W.R.1    Moody, D.M.2    Thore, C.R.3    Challa, V.R.4    Anstrom, J.A.5
  • 5
    • 0030770987 scopus 로고    scopus 로고
    • Translocation of myelin basic protein mRNA in oligodendrocytes requires microtubulus and kinesin
    • Carson, J. H., Worboys, K., Ainger, K., & Barbarese, E. (1997). Translocation of myelin basic protein mRNA in oligodendrocytes requires microtubulus and kinesin. Cell Motil Cytoskel, 38, 318-328.
    • (1997) Cell Motil Cytoskel , vol.38 , pp. 318-328
    • Carson, J.H.1    Worboys, K.2    Ainger, K.3    Barbarese, E.4
  • 8
    • 33845650701 scopus 로고    scopus 로고
    • Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury
    • Fornage, M., Mosley, T. H., Jack, C. R., Andrade, M., Kardia, S., Boerwinkle, E., et al. (2007). Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury. Human Genetics, 120, 671-680.
    • (2007) Human Genetics , vol.120 , pp. 671-680
    • Fornage, M.1    Mosley, T.H.2    Jack, C.R.3    Andrade, M.4    Kardia, S.5    Boerwinkle, E.6
  • 9
    • 0032717797 scopus 로고    scopus 로고
    • Myelin-associated oligodendrocytic basic protein mRNAs reside at different subcellular locations
    • Gould, R. M., Freund, C. M., & Barbarese, E. (1999). Myelin-associated oligodendrocytic basic protein mRNAs reside at different subcellular locations. Journal of Neurochemistry, 73, 1913-1924.
    • (1999) Journal of Neurochemistry , vol.73 , pp. 1913-1924
    • Gould, R.M.1    Freund, C.M.2    Barbarese, E.3
  • 11
    • 0037312568 scopus 로고    scopus 로고
    • Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis
    • Hassan, A., Hunt, B. J., O'Sullivan, M., Parmar, K., Bamford, J. M., Briley, D., et al. (2003). Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain, 126, 424-432.
    • (2003) Brain , vol.126 , pp. 424-432
    • Hassan, A.1    Hunt, B.J.2    O'Sullivan, M.3    Parmar, K.4    Bamford, J.M.5    Briley, D.6
  • 12
    • 33846116076 scopus 로고    scopus 로고
    • Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: The LADIS study
    • Inzitari, D., Simoni, M., Pracucci, G., Poggesi, A., Basile, A. M., Chabriat, H., et al. (2007). Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study. Archives of Internal Medicine, 167, 81-88.
    • (2007) Archives of Internal Medicine , vol.167 , pp. 81-88
    • Inzitari, D.1    Simoni, M.2    Pracucci, G.3    Poggesi, A.4    Basile, A.M.5    Chabriat, H.6
  • 13
  • 16
    • 0034131204 scopus 로고    scopus 로고
    • Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI
    • Markus, H. S., Lythgoe, D. J., Ostegaard, L., O'Sullivan, M., & Williams, S. C. R. (2000). Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI. Journal of Neurology, Neurosurgery and Psychiatry, 69, 48-53.
    • (2000) Journal of Neurology, Neurosurgery and Psychiatry , vol.69 , pp. 48-53
    • Markus, H.S.1    Lythgoe, D.J.2    Ostegaard, L.3    O'Sullivan, M.4    Williams, S.C.R.5
  • 17
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988). A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Research, 16, 1215-1218.
    • (1988) Nucleic Acids Research , vol.16 , pp. 1215-1218
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 18
    • 0025372402 scopus 로고
    • Features of the cerebral vascular pattern that predict vulnerability to perfusion or oxygenation deficiency: An anatomic study
    • Moody, D. M., Bell, M. A., & Chala, V. R. (1995). Features of the cerebral vascular pattern that predict vulnerability to perfusion or oxygenation deficiency: an anatomic study. American Journal of Neuroradiology, 11, 431-439.
    • (1995) American Journal of Neuroradiology , vol.11 , pp. 431-439
    • Moody, D.M.1    Bell, M.A.2    Chala, V.R.3
  • 19
    • 16544388607 scopus 로고    scopus 로고
    • Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosis
    • Moody, D. M., Thore, C. R., Anstrom, J. A., Challa, V. R., Langefeld, C. D., & Brown, W. R. (2004). Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosis. Radiology, 223, 883-890.
    • (2004) Radiology , vol.223 , pp. 883-890
    • Moody, D.M.1    Thore, C.R.2    Anstrom, J.A.3    Challa, V.R.4    Langefeld, C.D.5    Brown, W.R.6
  • 21
    • 0036126380 scopus 로고    scopus 로고
    • Pathophysiology of age-related cerebral white matter changes
    • Pantoni, L. (2002). Pathophysiology of age-related cerebral white matter changes. Cerebrovascular Diseases, 13(suppl. 2), 7-14.
    • (2002) Cerebrovascular Diseases , vol.13 , Issue.SUPPL. 2 , pp. 7-14
    • Pantoni, L.1
  • 22
    • 0030937940 scopus 로고    scopus 로고
    • Pathogenesis of leukoaraiosis, a review
    • Pantoni, L., & Garcia, J. H. (1997). Pathogenesis of leukoaraiosis, a review. Stroke, 28, 652-659.
    • (1997) Stroke , vol.28 , pp. 652-659
    • Pantoni, L.1    Garcia, J.H.2
  • 23
    • 33745618970 scopus 로고    scopus 로고
    • Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    • Pantoni, L., Poggesi, A., Basile, A. M., Pracucci, G., Barkhof, F., Chabriat, H., et al. (2006). Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study. Journal of the American Geriatrics Society, 54, 95-101.
    • (2006) Journal of the American Geriatrics Society , vol.54 , pp. 95-101
    • Pantoni, L.1    Poggesi, A.2    Basile, A.M.3    Pracucci, G.4    Barkhof, F.5    Chabriat, H.6
  • 24
    • 85152087991 scopus 로고
    • Anastomoses in the vascular bed of the human cerebrum
    • J. Cervós-Navarro Ed, Berlin, Germany: Walter de Gruyter
    • Ravens, J. R. (1994). Anastomoses in the vascular bed of the human cerebrum. In J. Cervós-Navarro (Ed.), Pathology of Cerebral Microcirculation (pp. 26-28). Berlin, Germany: Walter de Gruyter.
    • (1994) Pathology of Cerebral Microcirculation , pp. 26-28
    • Ravens, J.R.1
  • 26
    • 0035135594 scopus 로고    scopus 로고
    • Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: Results of the Austrian Stroke Prevention Study
    • Schmidt, H., Fazekas, F., Kostner, G. M., van Duijn, C. M. C., & Schmidt, R. (2001). Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention Study. Stroke, 32, 405-412.
    • (2001) Stroke , vol.32 , pp. 405-412
    • Schmidt, H.1    Fazekas, F.2    Kostner, G.M.3    van Duijn, C.M.C.4    Schmidt, R.5
  • 27
    • 0033941426 scopus 로고    scopus 로고
    • MRI cerebral white matter lesions and paraoxonase PON1 polymophism: Three-year follow-up of the Austrian Stroke Prevention Study
    • Schmidt, R., Schmidt, H., Fazekas, F., Kapeller, P., Roob, G., Lechner, A., et al. (2000). MRI cerebral white matter lesions and paraoxonase PON1 polymophism: three-year follow-up of the Austrian Stroke Prevention Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 20, 1811-1816.
    • (2000) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.20 , pp. 1811-1816
    • Schmidt, R.1    Schmidt, H.2    Fazekas, F.3    Kapeller, P.4    Roob, G.5    Lechner, A.6
  • 28
    • 0030958921 scopus 로고    scopus 로고
    • Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage. Results of the Austrian Stroke Prevention Study
    • Schmidt, R., Schmidt, H., Fazekas, F., Schumacher, M., Niederkorn, K., Kapeller, P., et al. (1997). Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage. Results of the Austrian Stroke Prevention Study. Stroke, 28, 951-956.
    • (1997) Stroke , vol.28 , pp. 951-956
    • Schmidt, R.1    Schmidt, H.2    Fazekas, F.3    Schumacher, M.4    Niederkorn, K.5    Kapeller, P.6
  • 29
    • 0023270438 scopus 로고
    • Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis)
    • Steingart, A., Hachinski, V. C., Lau, C., Fox, A. J., Diaz, F., Cape, R., et al. (1987a). Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis). Archives of Neurology, 44, 32-35.
    • (1987) Archives of Neurology , vol.44 , pp. 32-35
    • Steingart, A.1    Hachinski, V.C.2    Lau, C.3    Fox, A.J.4    Diaz, F.5    Cape, R.6
  • 30
    • 0023227863 scopus 로고
    • Cognitive and neurologic findings in demented patients with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis)
    • Steingart, A., Hachinski, V. C., Lau, C., Fox, A. J., Fox, H., Lee, D., et al. (1987b). Cognitive and neurologic findings in demented patients with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis). Archives of Neurology, 44, 36-39.
    • (1987) Archives of Neurology , vol.44 , pp. 36-39
    • Steingart, A.1    Hachinski, V.C.2    Lau, C.3    Fox, A.J.4    Fox, H.5    Lee, D.6
  • 31
    • 34247624500 scopus 로고    scopus 로고
    • Chemical events behind leukoaraiosis: Medicinal chemistry offers a new insight into a specific microcirculation disturbance in the brain (a chemical approach to a frequent cerebral phenotype)
    • Szolnoki, Z. (2007a). Chemical events behind leukoaraiosis: medicinal chemistry offers a new insight into a specific microcirculation disturbance in the brain (a chemical approach to a frequent cerebral phenotype). Current Medicinal Chemistry, 14, 1027-1236.
    • (2007) Current Medicinal Chemistry , vol.14 , pp. 1027-1236
    • Szolnoki, Z.1
  • 32
    • 34249777245 scopus 로고    scopus 로고
    • Genetic variant-associated endothelial dysfunction behind small-vessel cerebral circulatory disorders: A new pathomechanism behind common cerebral phenotypes (Review)
    • Szolnoki, Z. (2007b). Genetic variant-associated endothelial dysfunction behind small-vessel cerebral circulatory disorders: a new pathomechanism behind common cerebral phenotypes (Review). Mini Rev Med Chem, 7, 527-530.
    • (2007) Mini Rev Med Chem , vol.7 , pp. 527-530
    • Szolnoki, Z.1
  • 33
    • 33751075727 scopus 로고    scopus 로고
    • Pathomechanism of leukoaraiosis: A molecular bridge between the genetic, biochemical, and clinical processes (a mitochondrial hypothesis)
    • Szolnoki, Z. (2007c). Pathomechanism of leukoaraiosis: a molecular bridge between the genetic, biochemical, and clinical processes (a mitochondrial hypothesis). Neuromolecular Medicine, 9, 21-33.
    • (2007) Neuromolecular Medicine , vol.9 , pp. 21-33
    • Szolnoki, Z.1
  • 35
    • 1442325356 scopus 로고    scopus 로고
    • Specific APO E genotypes in combination with the ACE D/D or MTHFR 677TT mutation yield an independent genetic risk of leukoaraiosis
    • Szolnoki, Z., Somogyvari, F., Kondacs, A., Szabó, M., Fodor, L., Bene, J., et al. (2004). Specific APO E genotypes in combination with the ACE D/D or MTHFR 677TT mutation yield an independent genetic risk of leukoaraiosis. Acta Neurologica Scandinavica, 109, 222-227.
    • (2004) Acta Neurologica Scandinavica , vol.109 , pp. 222-227
    • Szolnoki, Z.1    Somogyvari, F.2    Kondacs, A.3    Szabó, M.4    Fodor, L.5    Bene, J.6
  • 36
    • 0031656710 scopus 로고    scopus 로고
    • Leukoaraiosis and vascular dementia
    • van Gijn, J. (1998). Leukoaraiosis and vascular dementia. Neurology, 51, 3-8.
    • (1998) Neurology , vol.51 , pp. 3-8
    • van Gijn, J.1
  • 37
    • 0037338557 scopus 로고    scopus 로고
    • Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?
    • Wardlaw, J. M., Sandercock, P. A. G., Dennis, M. S., & Starr, J. (2003). Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke, 34, 806-812.
    • (2003) Stroke , vol.34 , pp. 806-812
    • Wardlaw, J.M.1    Sandercock, P.A.G.2    Dennis, M.S.3    Starr, J.4
  • 38
    • 0003512785 scopus 로고
    • Diabetes mellitus. Report of WHO study group
    • World Health Organization
    • World Health Organization, Group WS (1985). Diabetes mellitus. Report of WHO study group. WHO Tech Rep Ser, 6, 13-17.
    • (1985) WHO Tech Rep Ser , vol.6 , pp. 13-17
    • Group, W.S.1
  • 40
    • 0027304103 scopus 로고
    • White matter changes in healthy elderly persons correlate with attention and speed of mental processing
    • Ylikoski, R., Ylikoski, A., Erkinjuntti, T., Sulkava, R., Raininko, R., & Tilvis, R. (1993). White matter changes in healthy elderly persons correlate with attention and speed of mental processing. Archives of Neurology, 50, 818-824.
    • (1993) Archives of Neurology , vol.50 , pp. 818-824
    • Ylikoski, R.1    Ylikoski, A.2    Erkinjuntti, T.3    Sulkava, R.4    Raininko, R.5    Tilvis, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.