Systems Biology of Vascular Calcification

Trends in Cardiovascular Medicine

Volumn 19, Issue 4, 2009, Pages 118-123

  Sage, Andrew ^a   Tintut, Yin ^a   Garfinkel, Alan ^a   Demer, Linda ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Department of Civil and Environmental Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CARBOXYGLUTAMIC ACID; BONE MORPHOGENETIC PROTEIN 2; FIBROBLAST GROWTH FACTOR 23;

ARTICLE; ATHEROSCLEROTIC PLAQUE; BIOMINERALIZATION; BLOOD VESSEL CALCIFICATION; COMPUTER MODEL; COMPUTER PREDICTION; COMPUTER SIMULATION; DIFFUSION COEFFICIENT; EXTRACELLULAR MATRIX; FEEDBACK SYSTEM; HUMAN; MATHEMATICAL MODEL; NONHUMAN; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SYSTEMS BIOLOGY;

CALCINOSIS; COMPUTER SIMULATION; FEEDBACK, PHYSIOLOGICAL; HUMANS; MODELS, CARDIOVASCULAR; SIGNAL TRANSDUCTION; STEM CELLS; SYSTEMS BIOLOGY; VASCULAR DISEASES;

EID: 70349761578     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcm.2009.07.002     Document Type: Article

References (28)

1. Ben-Dov I.Z., Galitzer H., Lavi-Moshayoff V., et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 117 (2007) 4003-4008
2. Bostrom K., Watson K.E., Horn S., et al. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest 91 (1993) 1800-1809
3. Cheng S.L., Shao J.S., Charlton-Kachigian N., et al. MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors. J Biol Chem 278 (2003) 45969-45977
4. Collett G.D., and Canfield A.E. Angiogenesis and pericytes in the initiation of ectopic calcification. Circ Res 96 (2005) 930-938
5. Demer L.L., and Tintut Y. Vascular calcification: pathobiology of a multifaceted disease. Circulation 117 (2008) 2938-2948
6. Farrington-Rock C., Crofts N.J., Doherty M.J., et al. Chondrogenic and adipogenic potential of microvascular pericytes. Circulation 110 (2004) 2226-2232
7. Garfinkel A., Tintut Y., Petrasek D., et al. Pattern formation by vascular mesenchymal cells. Proc Natl Acad Sci U S A 101 (2004) 9247-9250
8. Hamirani Y.S., Pandey S., Rivera J.J., et al. Markers of inflammation and coronary artery calcification: a systematic review. Atherosclerosis 201 (2008) 1-7
9. Inaba M., Okuno S., Imanishi Y., et al. Role of fibroblast growth factor-23 in peripheral vascular calcification in non-diabetic and diabetic hemodialysis patients. Osteoporos Int 17 (2006) 1506-1513
10. Isalan M., and Morrison M. This title is false. Nature 458 (2009) 969
11. Kirton J.P., Crofts N.J., George S.J., et al. Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease?. Circ Res 101 (2007) 581-589
12. London G.M., Marchais S.J., Guerin A.P., et al. Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD. J Am Soc Nephrol 19 (2008) 1827-1835
13. Morony S., Tintut Y., Zhang Z., et al. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation 117 (2008) 411-420
14. Murray J.D. Parameter space for turing instability in reaction diffusion mechanisms: a comparison of models. J Theor Biol 98 (1982) 143-163
15. Pauli R.M. Mechanism of bone and cartilage maldevelopment in the warfarin embryopathy. Pathol Immunopathol Res 7 (1988) 107-112
16. Sagawa K. The use of control theory and systems analysis in cardiovascular dynamics (1972), Academic Press Inc, New York
17. Sagawa K. Critique of a large-scale organ system model: Guytonian cardiovascular model. Ann Biomed Eng 3 (1975) 386-400
18. Shanahan C.M., Cary N.R., Metcalfe J.C., and Weissberg P.L. High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J Clin Invest 93 (1994) 2393-2402
19. Shao J.S., Aly Z.A., Lai C.F., et al. Vascular Bmp Msx2 Wnt signaling and oxidative stress in arterial calcification. Ann N Y Acad Sci 1117 (2007) 40-50
20. Shimada T., Kakitani M., Yamazaki Y., et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113 (2004) 561-568
21. Shroff R.C., McNair R., Figg N., et al. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 118 (2008) 1748-1757
22. Speer M.Y., Yang H.Y., Brabb T., et al. Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circ Res 104 (2009) 733-741
23. Tegner J., Skogsberg J., and Bjorkegren J. Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks underlying complex traits. J Lipid Res 48 (2007) 267-277
24. Tintut Y., Alfonso Z., Saini T., et al. Multilineage potential of cells from the artery wall. Circulation 108 (2003) 2505-2510
25. Tintut Y., Parhami F., Bostrom K., et al. cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification. J Biol Chem 273 (1998) 7547-7553
26. Turing A. The chemical basis of morphogenesis. Philosophical Transactions of the Royal Society of London (1952)
27. Vattikuti R., and Towler D.A. Osteogenic regulation of vascular calcification: an early perspective. Am J Physiol Endocrinol Metab 286 (2004) E686-E696
28. Zebboudj A.F., Imura M., and Bostrom K. Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2. J Biol Chem 277 (2002) 4388-4394