Spread of Serratia marcescens Coharboring aac(6')-Ib-cr, blaCTX-M, armA, and blaOXA-1 Carried by Conjugative IncL/M Type Plasmid in Korean Hospitals

Microbial Drug Resistance

Volumn 15, Issue 2, 2009, Pages 97-102

  Park, Yeon Joon ^a   Kim, Soo Young ^a   Yu, Jin Kyung ^a   Kim, Sang il ^a   Uh, Young ^b   Hong, Seong Geun ^c   Jongwook, Lee ^d   Kwak, Hyo Sun ^e  

^a The Catholic University of Korea   (South Korea)

^b Yonsei University Wonju College of Medicine   (South Korea)

^c CHA University   (South Korea)

^d Hanaro Medical Foundation   (South Korea)

^e Korea Food and Drug Administration   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL DNA; CIPROFLOXACIN; NALIDIXIC ACID;

ARTICLE; BACTERIAL GENE; BACTERIUM CONJUGATION; DRUG EFFECT; GENETICS; HOSPITAL; HUMAN; ISOLATION AND PURIFICATION; KOREA; MICROBIOLOGY; MULTIDRUG RESISTANCE; PLASMID; SERRATIA INFECTION; SERRATIA MARCESCENS;

ANTI-INFECTIVE AGENTS; CIPROFLOXACIN; CONJUGATION, GENETIC; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENES, BACTERIAL; HOSPITALS; HUMANS; KOREA; NALIDIXIC ACID; PLASMIDS; SERRATIA INFECTIONS; SERRATIA MARCESCENS;

EID: 70349760302     PISSN: 10766294     EISSN: 19318448     Source Type: Journal    
DOI: 10.1089/mdr.2009.0867     Document Type: Article

References (23)

1. Aubert, D., L. Poirel, J. Chevalier, S. Leotard, J.M. Pages, and P. Nordmann. 2001. Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 45:1615–1620.
2. Carattoli, A., A. Bertini, L. Villa, V. Falbo, K.L. Hopkins, and E.J. Threlfall. 2006. Identification of plasmids by PCR-based replicon typing. J. Microbiol. Methods 63:219–228.
3. Cordeiro, N.F., L. Robino, J. Medina, V. Seija, I. Bado, V. Garcia, M. Berro, J. Pontet, L. Loerpez, C. Bazet, G. Rieppi, G. Gutkind, J. Ayala, and R. Vignoli. 2008. Ciprofloxacin-resistant enterobacteria harboring the aac(6')-Ib-cr variant isolated from feces of inpatients in an intensive care unit in Uruguay. Antimicrob. Agents Chemother. 52:806–807.
4. Hopkins, K.L., E. Liebana, L. Villa, M. Batchelor, E.J. Threlfall, and A. Carattoli. 2006. Replicon typing and plasmids carrying CTX-M or CMY b-lactamases circulating among Salmonella and Escherichia coli isolates. Antimicrob. Agents Chemother. 50:3203–3206.
5. Jacoby, G.A. 2005. Mechanisms of resistance to quinolones. Clin. Infect. Dis. 41(Suppl 2):S120-S126.
6. Jacoby, G.A., K.E. Walsh, D.M. Mills, V.J. Walker, H. Oh, A. Robicsek, and D.C. Hooper. 2006. QnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob. Agents Chemother. 50:1178–1182.
7. Kang, H.Y., K.Y. Kim, J. Kim, J.C. Lee, Y.C. Lee, D.T. Cho, and S.Y. Seol. 2008. Distribution of conjugative-plasmid-mediated 16S rRNA methylase genes among amikacin-resistant Enterobacteriaceae isolates collected in 1995 to 1998 and 2001 to 2006 at a university hospital in South Korea and identification of conjugative plasmids mediating dissemination of 16S rRNA methylase. J. Clin. Microbiol. 46:700–706.
8. Kim, J., and Y.M. Lim. 2005. Prevalence of derepressed AmpC mutants and extended-spectrum b-lactamase producers among clinical isolates of Citrobacter freundii, Enterobacter spp., and Serratia marcescens in Korea: dissemination of CTX-M-3, TEM-52, and SHV-12. J. Clin. Microbiol. 43:2452–2455.
9. Kim, S.Y., Y.J. Park, J.K. Yu, and K.J. Han. 2008. Prevalence and genetic environment of aac(6')-Ib-cr in AmpC-producing Enterobacter cloacae, Citrobacter freundii and Serratia marcescens: a multicentre study from Korea. Abstract presented at the 18th Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona. Abstract no. P1529.
10. Lavilla, S., J.J. Gonzaález-López, M.N. Larrosa, R.M. Bar-tolomeé, and G. Prat. 2008. Prevalence of the quinolone-modifying enzyme aac(6')-Ib-cr in extended-spectrum b-lactamase-producing enterobacterial isolates in Barcelona. Abstract presented at the 18th Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona. Abstract no. P1523.
11. Machado, E., T.M. Coque, R. Cantoón, F. Baquero, J.C. Sousa, and L. Peixe. 2006. Portuguese Resistance Study Group. Dissemination in Portugal of CTX-M-15-, OXA-1-, and TEM-1-producing Enterobacteriaceae strains containing the aac(6')-Ib-cr gene, which encodes an aminoglycoside- and fluoroquinolone-modifying enzyme. Antimicrob. Agents Chemother. 50:3220–3221.
12. Martinez-Martinez, L., A. Pascual, and G.A. Jacoby. 1998. Quinolone resistance from a transferable plasmid. Lancet 351:797–799.
13. Pan, J.C., R. Ye, D.M. Meng, W. Zhang, H.Q. Wang, and K.Z. Liu. 2006. Molecular characteristics of class 1 and class 2 integrons and their relationships to antibiotic resistance in clinical isolates of Shigella sonnei and Shigella flexneri. J. Antimicrob. Chemother. 58:288–296.
14. Park, C.H., A. Robicsek, G.A. Jacoby, D. Sahm, and D.C. Hooper. 2006. Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme in the United States. Anti-microb. Agents Chemother. 50:3953–3955.
15. Park, Y.J., J.K. Yu, S. Lee, E.J. Oh, and G.J. Woo. 2007. Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multicentre study from Korea. J. Antimicrob. Chemother. 60:868–871.
16. Poirel, L., J.W. Decousser, and P. Nordmann. 2003. Insertion sequence ISEcp1B is involved in expression and mobilization of a bla(CTX-M) beta-lactamase gene. Antimicrob. Agents Chemother. 47:2938–2945.
17. Robicsek, A., G.A. Jacoby, and D.C. Hooper. 2006. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect. Dis. 6:629–640.
18. Sambrook, J., and D.W. Russell. 2001. Preparation of plasmid DNA by alkaline lysis with SDS: minipreparation. In J. Sanbrook, E.F. Fritsch, and T. Maniatis (ed.), Molecular Cloning, 3rd ed. Cold Spring Harbor, NY, pp. 1.32–1.34.
19. Tenover, F.C., R.D. Arbeit, R.V. Goering, P.A. Mickelsen, B.E. Murray, D.H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoreisis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233–2239.
20. Toleman, M.A., P.M. Bennett, and T.R. Walsh. 2006. ISCR elements: novel gene-capturing systems of the 21st century? Microbiol. Mol. Biol. Rev. 70:296–316.
21. Woodford, N., E.J. Fagan, and M.J. Ellington. 2006. Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases. J. Antimicrob. Chemother. 57: 154–155.
22. Yamane, K., Y. Doi, K. Yokoyama, T. Yagi, H. Kurokawa, N. Shibata, K. Shibayama, H. Kato, and Y. Arakawa. 2004. Genetic environments of the rmtA gene in Pseudomonas aeruginosa clinical isolates. Antimicrob. Agents Chemother. 48: 2069–2074.
23. Yamane, K., J. Wachino, S. Suzuki, K. Kimura, N. Shibata, H. Kato, K. Shibayama, T. Konda, and Y. Arakawa. 2007. New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob. Agents Chemother. 51:3354–3360.