Formation of spatial memory in rats with ischemic lesions to the prefrontal cortex; effects of a synthetic analog of ACTH(4-7)

Neuroscience and Behavioral Physiology

Volumn 39, Issue 8, 2009, Pages 749-756

  Silachev, D N ^a   Shram, S I ^a   Shakova, F M ^b   Romanova, G A ^b   Myasoedov, N F ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

^b INSTITUTE OF GENERAL PATHOLOGY AND PATHOPHYSIOLOGY   (Russian Federation)

Author keywords

Cerebral ischemia; Learning; Melanocortins; Morris water maze; Prefrontal area of the cerebral cortex; Semax; Spatial memory

Indexed keywords

CORTICOTROPIN DERIVATIVE; NEUROTROPHIC FACTOR; SEMAX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; LEARNING; MALE; MAZE TEST; MEMORY DISORDER; NEUROPROTECTION; NONHUMAN; PREFRONTAL CORTEX; PROTEIN SYNTHESIS; RAT; THROMBOSIS;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; HYPOXIA-ISCHEMIA, BRAIN; MAZE LEARNING; MEMORY; PEPTIDE FRAGMENTS; PREFRONTAL CORTEX; RATS; SPACE PERCEPTION;

EID: 70349757294     PISSN: 00970549     EISSN: 1573899X     Source Type: Journal    
DOI: 10.1007/s11055-009-9197-4     Document Type: Article

References (29)

1. I. P. Ashmarin, V. N. Nezavibat'ko, N. F. Myasoedov, A. A. Kamenskii, I. A. Grivennikov, M. A. Ponomareva-Stepnaya, L. A. Andreeva, A. Ya. Kaplan, and V. B. Koshelev, "A nootropic analog of adrenocorticotrophic hormone 4-10 - Semax (experience of 15 years of development and investigation)," Zh. Vyssh. Nerv. Deyat., 47, No. 2, 420-430 (1997).
2. I. A. Grivennikov, O. V. Dolotov, and Yu. I. Gol'dina, "Peptide factors in the processes of proliferation, differentiation, and maintenance of the viability of nervous system cells in mammals," Mol. Biol., 33, No. 1, 120-126 (1999).
3. A. Ya. Kaplan, V. B. Koshelev, V. N. Nezavibat'ko, and I. P. Ashmarin, "Increases in the hypoxia resistance of the body using the medicinal neuropeptide Semax," Fiziol. Cheloveka, 18, No. 5, 104-107 (1992).
4. M. A. Ponomareva-Stepnaya, V. N. Nezavibat'ko, L. V. Antonova, L. A. Andreeva, L. Yu. Alfeeva, V. N. Potaman, A. A. Kamenskii, and I. P. Ashmarin, "An ACTH4-10 analog - a long-acting learning stimulator," Khim.-Farm. Zh., No. 7, 790-795 (1984).
5. G. A. Romanov, "Dysregulatory impairments to integrative brain activity in focal cortical ischemia," in: Dysregulatory Pathology [in Russian], Meditsina, Moscow (2002), pp. 605-615.
6. G. A. Romanova, D. N. Silachev, F. M. Shakova, Yu. N. Kvashennikova, I. V. Viktorov, S. I. Shram, and N. F. Myasoedov, "Neuroprotective and antiamnestic actions of Semax in experimental ischemic cerebral cortical infarct," Byull. Éksperim. Biol. Med., 142, No. 12, 618-621 (2006).
7. É. R. Safarova, S. I. Shram, Yu. A. Zolotarev, and N. F. Myasoedov, "Effects of the peptide Semax on the survival of cultured rat pheochromocytoma cells in oxidative stress," Byull. Éksperim. Biol. Med., 135, No. 3, 309-313 (2003).
8. T. Y. Agapova, Y. V. Agniullin, M. I. Shadrina, S. I. Shram, P. A. Slominsky, S. A. Lymborska, and N. F. Myasoedov, "Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH 4-10," Neurosci. Lett., 417, No. 2, 201-205 (2007).
9. F. J. Antonawich and E. C. Azmitia, "Specificity versus redundancy of melanocortins in nerve regeneration," Ann. N.Y. Acad. Sci., 739, 60-73 (1994).
10. I. P. Ashmarin, V. N. Nezavibatko, N. G. Levitskaya, V. B. Koshelev, and A. A. Kamensky, "Design and investigation an ACTH (4-10) analogue lacking D-amino acids and hydrophobic radicals," Neurosci. Res. Commun., 16, 105-112 (1995).
11. M. J. Attella, S. W. Hoffman, M. P. Pilote, and D. G. Stein, "Effects of BIM-22015, an analog of ACTH4-10, on functional recovery after frontal cortex injury," Behav. Neural. Biol., 57, No. 2, 157-166 (1992).
12. O. V. Dolotov, E. A. Karpenko, L. S. Inozemtseva, T. S. Seredenina, N. G. Levitskaya, J. Rozyczka, E. V. Dubynina, E. V. Novosadova, L. A. Andreeva, L. Y. Alfeeva, A. A. Kamensky, I. A. Grivennikov, N. G. Myasoedov, and J. Engele, "Semax, an analog of ACTH (4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus," Brain Res., 1117, No. 1, 54-60 (2006).
13. R. D'Hooge and P. P. de Deyn, "Application of the Morris water maze in the study of learning and memory," Brain Res. Dev., 36, 60-90 (2001).
14. T. E. Hoh, B. Kolb, A. Eppel, C. H. Vanderwolf, and D. P. Cain, "Role of the neocortex in the water maze task in the rat: A detailed behavioral and Golgi-Cox analysis," Behav. Brain Res., 138, No. 1, 81-94 (2003).
15. M. W. Jones, "A comparative review of rodent prefrontal cortex and working memory," Curr. Mol. Med., 2, No. 7, 639-647 (2002).
16. B. Kolb, "Functions of the frontal cortex of the rat: A comparative review," Brain Res., 320, No. 1, 65-98 (1984).
17. N. G. Levitskaya, E. A. Sebentsova, L. A. Andreeva, L. Y. Alfeeva, A. A. Kamenitskii, and N. F. Myasoedov, "The neuroprotective effects of Semax in conditions of MPTP-induced lesions of the brain dopaminergic system," Neurosci. Behav. Physiol., 34, No. 4, 399-405 (2004).
18. R. G. Morris, "Developments of a water-maze procedure for studying spatial learning in the rat," J. Neurosci. Meth., 11, 47-60 (1984).
19. R. U. Ostrovskaya, G. A. Romanova, I. V. Barskov, E. V. Shanina, T. A. Gudasheva, I. V. Victorov, T. A. Voronina, and S. B. Seredenin, "Memory restoring and neuro-protective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model," Behav. Pharmacol., 10, No. 5, 549-553 (1999).
20. G. Paxinos and S. Watson, Atlas of Anatomy of Rat Brain. The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego (1986), Fig. 26.
21. M. E. Ragozzino, Ch. Wilcox, M. Raso, and R. P. Kesner, "Involvement of rodent prefrontal cortex subregions in strategy switching," Behav. Neurosci., 113, 32-41 (1999).
22. D. C. Rogers and A. J. Hunter, "Photothrombotic lesions of the rat cortex impair acquisition of the water-maze," Pharmacol. Biochem. Behav., 56, 747-754 (1997).
23. M. I. Shadrina, O. V. Dolotov, I. A. Grivennikov, P. A. Slominsky, L. A. Andreeva, L. S. Inozemtseva, S. A. Limborska, and N. F. Myasoedov, "Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog," Neurosci. Lett., 308, No. 2, 115-118 (2001).
24. E. V. Shanina, C. Redecker, S. Reinecke, T. Schallert, and O. W. Witte, "Long-term effects of sequential cortical infarcts on scar size, brain volume and cognitive function," Behav. Brain Res., 158, No. 1, 69-77 (2005).
25. B. D. Watson, "Animal models of photochemically induced brain ischemia and stroke," Cerebrovasc. Des., 1, 52-73 (1998).
26. B. D. Watson, W. D. Dietrich, R. Busto, M. S. Wachtel, and M. D. Ginsburg, "Induction of reproducible brain infarction by photochemically initiated thrombosis," Ann. Neurol., 17, No. 5, 497-504 (1985).
27. D. de Wied, "Pro-opio(melano)cortin and brain homeostasis," Prog. Brain Res., 55, 473-482 (1982).
28. D. de Wied, "Neuropeptides in learning and memory processes," Behav. Brain Res., 83, No. 1, 83-90 (1997).
29. D. de Wied and J. Jolles, "Neuropeptides derived from pro-opiocortin: Behavioral, physiological, and neurochemical effects," Physiol. Rev., 62, No. 3, 976-1059 (1982).