Intravenous immunoglobulin up-regulates the expression of the inhibitory FcγIIB receptor on B cells

Immunology and Cell Biology

Volumn 87, Issue 7, 2009, Pages 529-533

  Nikolova, Kalina A ^a   Tchorbanov, Andrey I ^a   Djoumerska Alexieva, Iglika K ^a   Nikolova, Maria ^b   Vassilev, Tchavdar L ^a  

^a INSTITUTE OF MICROBIOLOGY   (Bulgaria)

^b NATIONAL CENTER OF INFECTIOUS AND PARASITIC DISEASES   (Bulgaria)

Author keywords

Autoantibodies; Autoimmunity; B lymphocytes; Immunomodulation; Inhibitory receptors

Indexed keywords

DNA ANTIBODY; FC RECEPTOR IIB; IMMUNOGLOBULIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; DRUG MECHANISM; FEMALE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; B-LYMPHOCYTES; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FEMALE; IMMUNOGLOBULINS, INTRAVENOUS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; RECEPTORS, IGG; UP-REGULATION;

MUS;

EID: 70349740937     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2009.36     Document Type: Article

References (26)

1. Ravetch J, Lanier L. Immune inhibitory receptors. Science 2000; 290: 84-89.
2. Pritchard , Smith K. B cell inhibitory receptors and autoimmunity. Immunology 2003; 108: 263-273.
3. Nimmerjahn F. Activating and inhibitory FcγRs in autoimmune disorders. Spriger Semin Immunopathol 2006; 28: 305-319. (Pubitemid 44900570)
4. Bolland S, Ravetch J. Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis. Immunity 2000; 13: 277-285. (Pubitemid 30951893)
5. Moll T, Nitschke L, Carroll M, Ravetch J, Izui S. A critical role for FcγRIIB in the induction of rheumatoid factors. J Immunol 2004; 173: 4724-4728. (Pubitemid 39280708)
6. Mühlfeld A, Segerer S, Hudkins K, Carling M, Wen M, Farr A et al. Deletion of the Fcγ receptor IIb in thymic stromal lymphopoietin transgenic mice aggravates membrano-proliferative glomerulonephritis. Am J Pathol 2003; 163: 1127-1136. (Pubitemid 37040148)
7. 3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory FcγR. Int Immunol 2003; 15: 341-349.
8. Clynes R, Maizes J, Guinamard R, Ono M, Takai T, Ravetch J. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med 1999; 189: 179-185. (Pubitemid 29047037)
9. Nakamura A, Yuasa T, Ujike A, Ono M, Nukiwa T, Ravetch J et al. Fcγ receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. J Exp Med 2000; 191: 899-906. (Pubitemid 30690333)
10. McGaha T, Sorrentino B, Ravetch J. Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science 2005; 307: 590-593. (Pubitemid 40165683)
11. Mackay M, Stanevsky A, Wang T, Aranow C, Li M, Koenig S et al. Selective dysregulation of the FcγIIB receptor on memory B cells in SLE. J Exp Med 2006; 203: 2157-2164. (Pubitemid 44352236)
12. Su K, Yang H, Li X, Li X, Gibson A, Cafardi J et al. Expression profile of FcγRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. J Immunol 2007; 178: 3272-3280. (Pubitemid 46333211)
13. Chan O, Schlomchik M. A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice. J Immunol 1998; 160: 51-59. (Pubitemid 28116714)
14. Tchorbanov A, Voynova E, Mihaylova N, Todorov T, Nikolova M, Yomtova V et al. Selective silencing of DNA-specific B lymphocytes delays lupus activity in MRL/lpr mice. Eur J Immunol 2007; 37: 3587-3596.
15. Mihaylova N, Voynova E, Tchorbanov A, Nikolova M, Michova A, Todorov T et al. Selective silencing of disease-associated B-lymphocytes by chimeric molecules targeting their FcγIIb receptor. Int Immunol 2008; 20: 165-175. (Pubitemid 351234383)
16. Samuelsson A, Towers T, Ravetch J. Anti-inflammatory activity of IVIg mediated through the inhibitory Fc receptor. Science 2001; 291: 484-486. (Pubitemid 32097072)
17. Kaneko Y, Nimmerjahn F, Madaio M, Ravetch J. Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors. J Exp Med 2006; 203: 789-797.
18. Tackenberg B, Jelčić I, Baerenwaldt A, Oertel W, Sommer N, Nimmerjahn F et al. Impaired inhibitory Fcγ receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. Proc Natl Acad Sci USA 2009; 106: 4788-4792.
19. Kazatchkine M, Kaveri S. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med 2001; 345: 747-755. (Pubitemid 34936657)
20. Anthony R, Wermeling F, Karlsson M, Ravetch J. Identification of a receptor required for the anti-inflammatory activity of IVIG. Proc Natl Acad Sci U S A 2008; 105: 19571-19578.
21. Dietrich G, Algiman M, Sultan Y, Nydegger U, Kazatchkine M. Origin of anti-idiotypic activity against anti-factor VIII autoantibodies in pools of normal human immunoglobulin G (IVIg). Blood 1992; 79: 2946-2951.
22. Debré M, Bonnet M, Fridman W, Carosella E, Philippe N, Reinert P et al. Infusion of Fc gamma fragments for treatment of children with acute immune thrombocytopenic purpura. Lancet 1993; 342: 945-949. (Pubitemid 23305497)
23. Vassilev T, Yamamoto M, Aissaoui A, Bonnin E, Berrih-Aknin S, Kazatchkine M et al. Normal human immunoglobulin suppresses experimental myasthenia gravis in SCID mice. Eur J Immunol 1999; 29: 2436-2442. (Pubitemid 29378113)
24. Prasad N, Papoff G, Zeuner A, Bonnin E, Kazatchkine M, Ruberti G et al. Therapeutic preparations of normal polyspecific IgG (IVIg) induce apoptosis in human lymphocytes and monocytes: a novel mechanism of action of IVIg involving the Fas apoptotic pathway. J Immunol 1998; 161: 3781-3790. (Pubitemid 128470682)
25. Varambally S, Bar-Dayan Y, Bayry J, Lacroix-Desmazes S, Horn M, Sorel M et al. Natural human polyreactive IgM induce apoptosis of lymphoid cell lines and human peripheral blood mononuclear cells. Int Immunol 2004; 16: 517-524. (Pubitemid 38313160)
26. Mihaylova N, Voynova E, Tchorbanov A, Dolashka-Angelova P, Bayry J, Devreese B et al. Simultaneous engagement of FcγIIb and CD22 inhibitory receptors silences targeted B cells and suppresses autoimmune disease activity. Mol Immunol 2009 (in press; doi:10.1038/icb.2009.36).