Better control of early viral replication is associated with slower rate of elicited antiviral antibodies in the detuned enzyme immunoassay during primary HIV-1C infection

Journal of Acquired Immune Deficiency Syndromes

Volumn 52, Issue 2, 2009, Pages 265-272

  Novitsky, Vladimir ^a,b   Wang, Rui ^a   Kebaabetswe, Lemme ^b   Greenwald, Jamieson ^c   Rossenkhan, Raabya ^b   Moyo, Sikhulile ^b   Musonda, Rosemary ^a,b   Woldegabriel, Elias ^b   Lagakos, Stephen ^a   Essex, M ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BOTSWANA HARVARD AIDS INSTITUTE PARTNERSHIP   (Botswana)

^c HARVARD COLLEGE   (United States)

Author keywords

Botswana; Detuned assay; Primary HIV 1 subtype C infection; SOD; Viral load; Vironostika

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; VIRUS ANTIBODY;

ADOLESCENT; ADULT; ARTICLE; BOTSWANA; ENZYME IMMUNOASSAY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS 1 SUBTYPE C; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; MAJOR CLINICAL STUDY; MALE; PRIMARY INFECTION; PRIORITY JOURNAL; SEROCONVERSION; STRAIN DIFFERENCE; VIRUS LOAD; VIRUS REPLICATION;

ADULT; BOTSWANA; FEMALE; HIV ANTIBODIES; HIV INFECTIONS; HIV SEROPOSITIVITY; HIV-1; HUMANS; IMMUNOENZYME TECHNIQUES; INCIDENCE; MALE; MIDDLE AGED; TIME FACTORS; VIRAL LOAD; VIRUS REPLICATION; YOUNG ADULT;

EID: 70349706018     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181ab6ef0     Document Type: Article

References (29)

1. Brookmeyer R, Quinn TC. Estimation of current human immunodefi- ciency virus incidence rates from a cross-sectional survey using early diagnostic tests. Am J Epidemiol. 1995;141:166-172.
2. Janssen RS, Satten GA, Stramer SL, et al. New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes. JAMA. 1998;280:42-48.
3. Rawal BD, Degula A, Lebedeva L, et al. Development of a new lesssensitive enzyme immunoassay for detection of early HIV-1 infection. J Acquir Immune Defic Syndr. 2003;33:349-355.
4. Kothe D, Byers RH, Caudill SP, et al. Performance characteristics of a new less sensitive HIV-1 enzyme immunoassay for use in estimating HIV seroincidence. J Acquir Immune Defic Syndr. 2003;33:625-634.
5. Parekh BS, Kennedy MS, Dobbs T, et al. Quantitative detection of increasing HIV type 1 antibodies after seroconversion: a simple assay for detecting recent HIV infection and estimating incidence. AIDS Res Hum Retroviruses. 2002;18:295-307.
6. Suligoi B, Galli C, Massi M, et al. Precision and accuracy of a procedure for detecting recent human immunodeficiency virus infections by calculating the antibody avidity index by an automated immunoassaybased method. J Clin Microbiol. 2002;40:4015-4020.
7. Soroka SD, Granade TC, Candal D, et al. Modification of rapid human immunodeficiency virus (HIV) antibody assay protocols for detecting recent HIV seroconversion. Clin Diagn Lab Immunol. 2005;12: 918-921.
8. Wilson KM, Johnson EI, Croom HA, et al. Incidence immunoassay for distinguishing recent from established HIV-1 infection in therapy-naive populations. AIDS. 2004;18:2253-2259.
9. Barin F, Meyer L, Lancar R, et al. Development and validation of an immunoassay for identification of recent human immunodeficiency virus type 1 infections and its use on dried serum spots. J Clin Microbiol. 2005; 43:4441-4447.
10. Li H, Ketema F, Sill AM, et al. A simple and inexpensive particle agglutination test to distinguish recent from established HIV-1 infection. Int J Infect Dis. 2007;11:459-465.
11. Cleghorn FR, Jack N, Murphy JR, et al. Direct and indirect estimates of HIV-1 incidence in a high-prevalence population. Am J Epidemiol. 1998; 147:834-839.
12. Hargrove JW, Humphrey JH, Mutasa K, et al. Improved HIV-1 incidence estimates using the BED capture enzyme immunoassay. AIDS. 2008;22: 511-518.
13. Lagakos S, Gable A, eds. Methodological Challenges in Biomedical HIV Prevention Trials. Washington, DC: National Academy Press; 2008; 175-185.
14. McDougal JS, Parekh BS, Peterson ML, et al. Comparison of HIV type 1 incidence observed during longitudinal follow-up with incidence estimated by cross-sectional analysis using the BED capture enzyme immunoassay. AIDS Res Hum Retroviruses. 2006;22:945-952.
15. Karita E, Price M, Hunter E, et al. Investigating the utility of the HIV-1 BED capture enzyme immunoassay using cross-sectional and longitudinal seroconverter specimens from Africa. AIDS. 2007;21:403-408.
16. Laeyendecker O, Rothman RE, Henson C, et al. The effect of viral suppression on cross-sectional incidence testing in the Johns Hopkins hospital emergency department. J Acquir Immune Defic Syndr. 2008;48: 211-215.
17. Morris MK, Katzenstein DA, Israelski D, et al. Characterization of the HIV-1 specific humoral immune response during highly active antiretroviral therapy (HAART). J Acquir Immune Defic Syndr. 2001;28: 405-415.
18. Gupta SB, Murphy G, Koenig E, et al. Comparison of methods to detect recent HIV type 1 infection in cross-sectionally collected specimens from a cohort of female sex workers in the Dominican Republic. AIDS Res Hum Retroviruses. 2007;23:1475-1480.
19. Buchacz K, Klausner JD, Kerndt PR, et al. HIV incidence among men diagnosed with early syphilis in Atlanta, San Francisco, and Los Angeles, 2004 to 2005. J Acquir Immune Defic Syndr. 2008;47:234-240.
20. Priddy FH, Pilcher CD, Moore RH, et al. Detection of acute HIV infections in an urban HIV counseling and testing population in the United States. J Acquir Immune Defic Syndr. 2007;44:196-202.
21. Sakarovitch C, Rouet F, Murphy G, et al. Do tests devised to detect recent HIV-1 infection provide reliable estimates of incidence in Africa? J Acquir Immune Defic Syndr. 2007;45:115-122.
22. Novitsky V, Woldegabriel E, Wester C, et al. Identification of primary HIV-1C infection in Botswana. NIHMSID # 79283. AIDS Care. 2008;20: 806-811.
23. Novitsky V,Woldegabriel E, Kebaabetswe L, et al. Viral load and CD4+ T cell dynamics in primary HIV-1 subtype C infection. J Acquir Immune Defic Syndr. 2009;50:65-76.
24. Speers D, Phillips P, Dyer J. Combination assay detecting both human immunodeficiency virus (HIV) p24 antigen and anti-HIVantibodies opens a second diagnostic window. J Clin Microbiol. 2005;43:5397-5399.
25. Novitsky VA, Gilbert PB, Shea K, et al. Interactive association of proviral load and IFN-gamma-secreting T cell responses in HIV-1C infection. Virology. 2006;349:142-155.
26. Fiebig EW, Wright DJ, Rawal BD, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS. 2003;17:1871-1879.
27. Salazar-Gonzalez JF, Bailes E, Pham KT, et al. Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing. J Virol. 2008;82:3952-3970.
28. Young CL, Hu DJ, Byers R, et al. Evaluation of a sensitive/less sensitive testing algorithm using the bioMerieux Vironostika-LS assay for detecting recent HIV-1 subtype B or E infection in Thailand. AIDS Res Hum Retroviruses. 2003;19:481-486.
29. Hu DJ, Vanichseni S, Mastro TD, et al. Viral load differences in early infection with two HIV-1 subtypes. AIDS. 2001;15:683-691.