In vivo and in vitro evidence of the involvement of CXCL1, a Keratinocyte-derived chemokine, in equine laminitis

Journal of Veterinary Internal Medicine

Volumn 23, Issue 5, 2009, Pages 1086-1096

  Faleiros, R R ^a,b   Leise, B B ^a   Westerman, T ^a   Yin, C ^a   Nuovo, G J ^a   Belknap, J K ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Cell culturing; Cytokines; Horse; PCR assays

Indexed keywords

CXCL1 CHEMOKINE; MESSENGER RNA; TOLL LIKE RECEPTOR;

ANIMAL; ANIMAL DISEASE; ANIMAL LAMENESS; ARTICLE; BIOSYNTHESIS; CELL HYPOXIA; FOOT DISEASE; GENETICS; HORSE; HORSE DISEASE; IMMUNOLOGY; OXIDATIVE STRESS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL HYPOXIA; CHEMOKINE CXCL1; FOOT DISEASES; HORSE DISEASES; HORSES; LAMENESS, ANIMAL; OXIDATIVE STRESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOLL-LIKE RECEPTORS;

ANIMALIA; EQUIDAE; JUGLANS NIGRA; RODENTIA;

EID: 70349693802     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2009.0349.x     Document Type: Article

References (52)

1. Black SJ, Lunn DP, Yin C, et al. Leukocyte emigration in the early stages of laminitis. Vet Immunol Immunopathol 2006;109: 161-166.
2. Loftus JP, Belknap JK, Black SJ. Matrix metalloproteinase-9 in laminae of black walnut extract treated horses correlates with neutrophil abundance. Vet Immunol Immunopathol 2006;113:267-276.
3. Belknap JK, Giguere S, Pettigrew A, et al. Lamellar proinflammatory cytokine expression patterns in laminitis at the developmental stage and at the onset of lameness: Innate vs. adaptive immune response. Equine Vet J 2007;39:42-47.
4. Loftus JP, Black SJ, Pettigrew A, et al. Early laminar events involving endothelial activation in horses with black walnutinduced laminitis. Am J Vet Res 2007;68:1205-1211.
5. Stewart AJ, Pettigrew A, Cochran AM, Belknap JK. Indices of inflammation in the lung and liver in the early stages of the black walnut extract model of equine laminitis. Vet Immunol Immunopathol 2009;129:254-260.
6. Fink MP, Delude RL. Epithelial barrier dysfunction: A unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin 2005;21:177-196.
7. Laing KJ, Secombes CJ. Chemokines. Dev Comp Immunol 2004;28:443-460.
8. Bechara C, Chai H, Lin PH, et al. Growth related oncogenealpha (GRO-alpha): Roles in atherosclerosis, angiogenesis and other inflammatory conditions. Med Sci Monit 2007;13:RA87-RA90.
9. Smith DF, Galkina E, Ley K, Huo Y. GRO family chemokines are specialized for monocyte arrest from flow. Am J Physiol Heart Circ Physiol 2005;289:H1976-H1984.
10. Gillitzer R, Goebeler M. Chemokines in cutaneous wound healing. J Leukoc Biol 2001;69:513-521.
11. Strieter RM, Polverini PJ, Kunkel SL, et al. The functional role of the ELR motif in CXC chemokinemediated angiogenesis. J Biol Chem 1995;270:27348-27357.
12. Rennekampff HO, Hansbrough JF, Woods V Jr, et al. Role of melanoma growth stimulatory activity (MGSA/gro) on keratinocyte function in wound healing. Arch Dermatol Res 1997;289: 204-212.
13. Li J, Thornhill MH. Growth-regulated peptide-alpha (GROalpha) production by oral keratinocytes: A comparison with skin keratinocytes. Cytokine 2000;12:1409-1413.
14. Molls RR, Savransky V, Liu M, et al. Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury. Am J Physiol Renal Physiol 2006;290:F1187-F1193.
15. Gillitzer R, Ritter U, Spandau U, et al. Differential expression of GRO-alpha and IL-8 mRNA in psoriasis: A model for neutrophil migration and accumulation in vivo. J Invest Dermatol 1996;107:778-782.
16. Ainsworth DM, Wagner B, Franchini M, et al. Time-dependent alterations in gene expression of interleukin-8 in the bronchial epithelium of horses with recurrent airway obstruction. Am J Vet Res 2006;67:669-677.
17. Souza DG, Bertini R, Vieira AT, et al. Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury. Br J Pharmacol 2004;143:132-142.
18. Reutershan J, Morris MA, Burcin TL, et al. Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung. J Clin Invest 2006;116:695-702.
19. Frink M, Hsieh YC, Hsieh CH, et al. Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage. Shock 2007;28:576-581.
20. Leise BS, Yin C, Pettigrew A, Belknap JK. Proinflammatory cytokine responses of cultured equine keratinocytes to bacterial pathogen-associated molecular pattern (PAMP) motifs. Equine Vet J, in press.
21. Deroc JM, Segui M, Poinot-Chazel C, et al. Interleukin-13 stimulates interleukin-6 production by human keratinocytes. Similarity with interleukin-4. FEBS 1994;343:32-36.
22. Ibisch C, Bourdeau P, Cadiot C, et al. Upregulation of TNF-alpha production by IFN-gamma and LPS in cultured canine keratinocytes: Application to monosaccharides effects. Vet Res Commun 2007;31:835-846.
23. Pivarcsi A, Bodai L, Rethi B, et al. Expression and function of Toll-like receptors 2 and 4 in human keratinocytes. Int Immunol 2003;15:721-730.
24. Pleguezuelos O, Dainty SJ, Kapas S, Taylor JJ. A human oral keratinocyte cell line responds to human heat shock protein 60 through activation of ERK1/2 MAP kinases and up-regulation of IL-1beta. Clin Exp Immunol 2005;141:307-314.
25. Lebre MC, van der Aar AM, van Baarsen L, et al. Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 2007;127:331-341.
26. Jazwa A, Loboda A, Golda S, et al. Effect of heme and heme oxygenase1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes. Free Radic Biol Med 2006;40:1250-1263.
27. Malhotra R, Tyson DW, Rosevear HM, Brosius FC. Hypoxia-inducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells. BMC Cardiovasc Disord 2008;8:9-13.
28. Robinson A, Keely S, Karhausen J, et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 2008;134:145-155.
29. Waguespack RW, Cochran A, Belknap JK. Expression of the cyclooxygenase isoforms in the prodromal stage of black walnut-induced laminitis in horses. Am J Vet Res 2004;65:1724-1729.
30. Waguespack RW, Kemppainen RJ, Cochran A, et al. Increased expression of MAIL, a cytokine-associated nuclear protein, in the prodromal stage of black walnut-induced laminitis. Equine Vet J 2004;36:285-291.
31. Nuovo GJ. PCR In Situ Hybridization: Protocols and Applications, 3rd ed. Baltimore, MD: Lippincott Williams and Wilkins Press; 1997.
32. Nuovo GJ. In situ detection of precursor and mature micro-RNAs in paraffin embedded, formalin fixed tissues and cell preparations. Methods 2008;44:39-46.
33. Blackwell TS, Lancaster LH, Blackwell TR, et al. Chemotactic gradients predict neutrophilic alveolitis in endotoxintreated rats. Am J Respir Crit Care Med 1999;159:1644-1652.
34. Brown KA, Brain SD, Pearson JD, et al. Neutrophils in development of multiple organ failure in sepsis. Lancet 2006;68:57-69.
35. Pollitt CC. Basement membrane pathology: A feature of acute equine laminitis. Equine Vet J 1996;28:38-46.
36. French KR, Pollitt CC. Equine laminitis: Loss of hemidesmosomes in hoof secondary epidermal lamellae correlates to dose in an oligofructose induction model: an ultrastructural study. Equine Vet J 2004;36:230-235.
37. Nourian AR, Baldwin GI, van Eps AW, Pollitt CC. Equine laminitis: Ultrastructural lesions detected 24-30 hours after induction with oligofructose. Equine Vet J 2007;39:360-364.
38. Faleiros RR, Nuovo GJ, Belknap JK. Calprotectin in myeloid and epithelial cells of laminae from horses with black walnut extractinduced laminitis. J Vet Int Med 2009;23:174-181.
39. Tarlowe MH, Duffy A, Kannan KB, et al. Prospective study of neutrophil chemokine responses in trauma patients at risk for pneumonia. Am J Respir Crit Care Med 2005;171:753-759.
40. Stefanovic L, Stefanovic B. Mechanism of direct hepatotoxic effect of KC chemokine: Sequential activation of gene expression and progression from inflammation to necrosis. J Interferon Cytokine Res 2006;26:760-770.
41. Eaton SA, Allen D, Eades SC, Schneider DA. Digital starling forces and hemodynamics during early laminitis induced by an aqueous extract of black walnut (Juglans nigra) in horses. Am J Vet Res 1995;56:1338-1344.
42. Adair HS, Goble DO, Schmidhammer JL, Shires GM. Laminar microvascular flow, measured by means of laser Doppler flowmetry, during the prodromal stages of black walnut-induced laminitis in horses. Am J Vet Res 2000;61:862-868.
43. Davis JL, Blikslager AT, Catto K, Jones SL. A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002). J Vet Intern Med 2003;17:896-901.
44. Minnick PD, Brown CM, Braselton WE, et al. The induction of equine laminitis with an aqueous extract of the heartwood of black walnut (Juglans nigra). Vet Hum Toxicol 1987;29:230-233.
45. McConnico RS, Stokes AM, Eades SC, Moore RM. Investigation of the effect of black walnut extract on in vitro ion transport and structure of equine colonic mucosa. Am J Vet Res 2005;66:443-449.
46. Merritt A. Where does the subject of black walnut extractinduced laminitis fit into a colic symposium? Equine Vet J 2005;37:289-291.
47. Buras JA, Holzmann B, Sitkovsky M. Animal models of sepsis: Setting the stage. Nat Rev Drug Discov 2005;4:854-865.
48. Hurley DJ, Parks RJ, Reber AJ, et al. Dynamic changes in circulating leukocytes during the induction of equine laminitis with black walnut extract. Vet Immunol Immunopathol 2006;110: 195-206.
49. Parsons CS, Orsini JA, Krafty R, et al. Risk factors for development of acute laminitis in horses during hospitalization: 73 cases (1997-2004). J Am Vet Med Assoc 2007;230:885-889.
50. Catani MV, Savini I, Rossi A, et al. Biological role of vitamin C in keratinocytes. Nutr Rev 2005;63:81-90.
51. O'Toole EA, Marinkovich MP, Peavey CL, et al. Hypoxia increases human keratinocyte motility on connective tissue. J Clin Invest 1997;100:2881-2891.
52. Kino-oka M, Agatahama Y, Haga Y, et al. Long-term subculture of human keratinocytes under an anoxic condition. Biosci Bioeng 2005;100:119-122.