The Legionella pneumophila Dps homolog is regulated by iron and involved in multiple stress tolerance

Journal of Basic Microbiology

Volumn 49, Issue SUPPL. 1, 2009, Pages

  Yu, Ming Jia ^a   Ren, Jun ^a   Zeng, Yong Iun ^a   Zhou, Shi Ning ^a   Lu, Yong Jun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Dps; Iron storage; Legionella pneumophila; Stress response

Indexed keywords

BACTERIAL PROTEIN; FERRITIN; HYDROGEN PEROXIDE; IRON;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEAT; LEGIONELLA PNEUMOPHILA; METABOLISM; MOLECULAR GENETICS; MUTATION; OXIDATIVE STRESS; PATHOGENICITY; SEQUENCE ALIGNMENT; VIRULENCE;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; FERRITINS; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; HOT TEMPERATURE; HYDROGEN PEROXIDE; IRON; LEGIONELLA PNEUMOPHILA; MOLECULAR SEQUENCE DATA; MUTATION; OXIDATIVE STRESS; SEQUENCE ALIGNMENT; VIRULENCE;

LEGIONELLA PNEUMOPHILA;

EID: 70349673796     PISSN: 0233111X     EISSN: 15214028     Source Type: Journal    
DOI: 10.1002/jobm.200800357     Document Type: Article

References (35)

1. Guerinot, M.L., 1994. Microbial iron transport. Annu. Rev. Microbiol., 48, 743-772.
2. Imlay, J.A., Chin, S.M. and Linn, S., 1988. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science, 240, 640-642.
3. Andrews, S.C., Robinson, A.K. and Rodríguez-Quiñones, F., 2003. Bacterial iron homeostasis. FEMS. Microbiol. Rev., 27, 215-237.
4. Sen, A., Dwivedi, K., Rice, K.A., Bullerjahn, G.S., 2000. Growth phase and metal-dependent regulation of the dpsA gene in Synechococcus sp. strain PCC 7942, USA. Arch. Microbiol., 173, 352-357.
5. Polidoro, M., De Biase, D., Montagnini, B. et al., 2002. The expression of the dodecameric ferritin in Listeria spp. is induced by iron limitation and stationary growth phase. Gene, 296, 121-128.
6. Martinez, A. and Kolter, R., 1997. Protection of DNA during oxidative stress by the nonspecific DNA-binding protein Dps. J. Bacteriol., 179, 5188-5194.
7. Ceci, P., Ilari, A., Falvo, E., Chiancone, E., 2003. The Dps protein of Agrobacterium tumefaciens does not bind to DNA but protects it toward oxidative cleavage: X-ray crystal structure, iron binding, and hydroxyl-radical scavenging properties. J. Biol. Chem., 278, 20319-20326.
8. Nair, S. and Finkel, S.E., 2004. Dps protects cells against multiple stresses during stationary phase. J. Bacteriol., 186, 4192-4198.
9. Almirón, M., Link, A.J., Furlong, D. and Kolter, R., 1992. A novel DNA-binding protein with regulatory and protective roles in starved Escherichia coli. Genes. Dev., 6, 2646-2654.
10. Fraser, D.W., Tsai, T.R., Orenstein, W. et al., 1977. Legionnaires' disease: description of an epidemic of pneumonia. N. Engl. J. Med., 297, 1189-1197.
11. Cianciotto, N.P., 2007. Iron acquisition by Legionella pneumophila. Biometals, 20, 323-331.
12. Park, M., Yun, S.T., Hwang, S.Y., Chun, C.I. and Ahn, T.I., 2006. The dps gene of symbiotic "Candidatus Legionella jeonii" in Amoeba proteus responds to hydrogen peroxide and phagocytosis. J. Bacteriol., 188, 7572-7580.
13. Liu, Y. and Luo, Z.Q., 2007. The Legionella pneumophila effector SidJ is required for efficient recruitment of endoplasmic reticulum proteins to the bacterial phagosome. Infect. Immun., 75, 592-603.
14. Berger, K.H. and Isberg, R.R., 1993. Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol. Microbiol., 7, 7-19.
15. LeBlanc, J.J., Davidson, R.J. and Hoffman, P.S., 2006. Compensatory functions of two alkyl hydroperoxide reductases in the oxidative defense system of Legionella pneumophila. J. Bacteriol., 188, 6235-6244.
16. Ho, S.N., Hunt, H.D., Horton, R.M., Pullen, J.K. and Pease, L.R. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene, 77, 51-59.
17. Yu, H.B., Zhang, Y.L., Lau, Y.L. et al., 2005. Identification and characterization of putative virulence genes and gene clusters in Aeromonas hydrophila PPD134/91. Appl. Environ. Microbiol., 71, 4469-4477.
18. Shi, C., Forsbach-Birk, V., Marre, R. and McNealy, T.L., 2006. The Legionella pneumophila global regulatory protein LetA affects DotA and Mip. Int. J. Med. Microbiol., 296, 15-24.
19. Hales, L.M. and Shuman, H.A., 1999. The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii. J. Bacteriol., 181, 4879-4889.
20. Ilari, A., Stefanini, S., Chiancone, E. and Tsernoglou, D., 2000. The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site. Nat. Struct. Biol., 7, 38-43.
21. Vogel, J.P. and Isberg, R.R., 1999. Cell biology of Legionella pneumophila. Curr. Opin. Microbiol., 2, 30-34.
22. Fiorini, F., Stefanini, S., Valenti, P., Chiancone, E. and De, Biase. D., 2008. Transcription of the Listeria monocytogenes fri gene is growth-phase dependent and is repressed directly by Fur, the ferric uptake regulator. Gene, 410, 113-121.
23. Reindel, S., Schmidt, C.L., Anemüller, S. and Matzanke, B.F., 2006. Expression and regulation pattern of ferritinlike DpsA in the archaeon Halobacterium salinarum. Biometals, 19, 19-29.
24. Horsburgh, M.J., Ingham, E. and Foster, S.J., 2001. In Staphylococcus aureus, fur is an interactive regulator with PerR, contributes to virulence, and is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasis. J. Bacteriol., 183, 468-475.
25. Gupta, S. and Chatterji, D., 2003. Bimodal protection of DNA by Mycobacterium smegmatis DNA-binding protein from stationary phase cells. J. Biol. Chem., 278, 5235-5241.
26. Ceci, P., Ilari, A., Falvo, E. and Chiancone, E., 2003. The Dps protein of Agrobacterium tumefaciens does not bind to DNA but protects it toward oxidative cleavage: X-ray crystal structure, iron binding, and hydroxyl-radical scavenging properties. J. Biol. Chem., 278, 20319-20326.
27. Olsen, K.N., Larsen, M.H., Gahan, C.G. et al., 2005. The Dps-like protein Fri of Listeria monocytogenes promotes stress tolerance and intracellular multiplication in macrophage-like cells. Microbiology, 151, 925-933.
28. Zhao, G., Ceci, P., Ilari, A., et al. 2002. Iron and hydrogen peroxide detoxification properties of DNA-binding protein from starved cells. A ferritin-like DNA-binding protein of Escherichia coli. J. Biol. Chem., 277, 27689-27696.
29. Wiedenheft, B., Mosolf, J., Willits, D. et al., 2005. An archaeal antioxidant: characterization of a Dps-like protein from Sulfolobus solfataricus. Proc. Natl. Acad. Sci. USA, 102, 10551-10556.
30. Densen, P., Clark, R.A. and Nauseef, W.M., 1990. Principles and practice of infectious diseases. In: Granulocytic Phagocytes (Mandell, G.L., Douglas, R.G. and Bennett, J.E., eds.), pp. 78-101. Churchill Livingstone, New York.
31. Horwitz, M.A., 1984. Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Cell, 36, 27-33.
32. Bachman, M.A. and Swanson, M.S., 2001. RpoS co-operates with other factors to induce Legionella pneumophila virulence in the stationary phase. Mol. Microbiol., 40, 1201-1214.
33. Tiaden, A., Spirig, T., Weber, S.S. et al., 2007. The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA. Cell. Microbiol., 9, 2903-2920.
34. Miyake, M., Watanabe, T., Koike, H. et al., 2005, Characterization of Legionella pneumophila pmiA, a gene essential for infectivity of protozoa and macrophages. Infect. Immun., 73, 6272-6282.
35. Katz, S.M. and Hammel, J.M., 1987. The effect of drying, heat, and pH on the survival of Legionella pneumophila. Ann. Clin. Lab. Sci., 17, 150-156.