Editorial: Could insulin sensitization be used as an alternative to intensive insulin therapy to improve the survival of intensive care unit patients with stress-induced hyperglycemia?

Critical Care Medicine

Volumn 37, Issue 10, 2009, Pages 2856-2858

  Kaneki, Masao ^a   Shinozaki, Shohei ^a   Chang, Kyungho ^b   Shimizu, Nobuyuki ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Insulin sensitization; Intensive insulin therapy; Stress induced hyperglycemia

Indexed keywords

ANTIDIABETIC AGENT; GLITAZONE DERIVATIVE; GLUCOSE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; METFORMIN; OLIGODEOXYNUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RESVERATROL;

BLOOD GLUCOSE MONITORING; DRUG RECEPTOR BINDING; DRUG SENSITIZATION; EDITORIAL; HYPERGLYCEMIA; INSULIN SENSITIVITY; INSULIN TREATMENT; INTENSIVE CARE UNIT; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROGNOSIS; STRESS; SURVIVAL; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; HUMAN; HYPERINSULINISM; INSULIN RESISTANCE; MENTAL STRESS; MORTALITY; MOUSE; NOTE; PATHOPHYSIOLOGY; PHYSIOLOGY; SEPSIS;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; HYPERGLYCEMIA; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; INTENSIVE CARE UNITS; MICE; NF-KAPPA B; SEPSIS; STRESS, PSYCHOLOGICAL;

EID: 70349661481     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181aff7bb     Document Type: Editorial

References (17)

1. van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367
2. Brunkhorst FM, Engel C, Bloos F, et al: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358:125-139
3. Finfer S, Chittock DR, Su SY, et al: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360: 1283-1297
4. Griesdale DE, de Souza RJ, van Dam RM, et al: Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ 2009; 180:821-827; discussion 799-800
5. Wiener RS, Wiener DC, Larson RJ: Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA 2008; 300: 933-944
6. Inzucchi SE, Siegel MD: Glucose control in the ICU: how tight is too tight? N Engl J Med 2009; 360:1346-1349
7. Balasubramanyam A: Intensive glycemic control in the intensive care unit: promises and pitfalls. J Clin Endocrinol Metab 2009; 94:416-417
8. Kaneki M, Sakai M, Shimizu N, et al: Is normalized mean blood glucose level good enough for the intensive care unit?- glycemic variability as a new independent predictor of mortality. Crit Care Med 2008; 36:3104-3106
9. Krinsley JS: Glycemic variability: a strong independent predictor of mortality in critically ill patients. Crit Care Med 2008; 36: 3008-3013
10. Egi M, Bellomo R, Stachowski E, et al: Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 2006; 105:244-252
11. Jiang ZY, Lin YW, Clemont A, et al: Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 1999; 104:447-457
12. Sugita H, Kaneki M, Sugita M, et al: Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle. Am J Physiol Endocrinol Metab 2005; 288:E585-E591
13. Matsuda N, Yamamoto S, Yokoo H, et al: Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med 2009; 37:2791-2799
14. Martyn JA, Kaneki M, Yasuhara S: Obesityinduced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms. Anesthesiology 2008; 109:137-148
15. Zauner A, Nimmerrichter P, Anderwald C, et al: Severity of insulin resistance in critically ill medical patients. Metabolism 2007; 56:1-5
16. Milne JC, Lambert PD, Schenk S, et al: Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007; 450:712-716
17. Hsu CP, Odewale I, Alcendor RR, et al: Sirt1 protects the heart from aging and stress. Biol Chem 2008; 389:221-231