메뉴 건너뛰기




Volumn 31, Issue 5, 2009, Pages 542-548

Genetic polymorphisms of MRP2 and UGT2B7 and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid

Author keywords

Gastrointestinal Symptom Rating Scale; Genetic polymorphisms; Mycophenolic acid

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN; GLUCURONOSYLTRANSFERASE 2B7; MULTIDRUG RESISTANCE PROTEIN 2; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

EID: 70349658283     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e3181b1dd5e     Document Type: Article
Times cited : (27)

References (28)
  • 1
    • 33747494883 scopus 로고    scopus 로고
    • Mycophenolate mofetil dose reductions and discontinuations after gastrointestinal complications are associated with renal transplant graft failure
    • Bunnapradist S, Lentine KL, Burroughs TE, et al. Mycophenolate mofetil dose reductions and discontinuations after gastrointestinal complications are associated with renal transplant graft failure. Transplantation. 2006; 82:102-107.
    • (2006) Transplantation , vol.82 , pp. 102-107
    • Bunnapradist, S.1    Lentine, K.L.2    Burroughs, T.E.3
  • 2
    • 0042536429 scopus 로고    scopus 로고
    • Mycophenolate dose reduction and the risk of acute rejection after renal transplantation
    • Knoll GA, MacDonald I, Khan A, et al. Mycophenolate dose reduction and the risk of acute rejection after renal transplantation. J Am Soc Nephrol. 2003;14:2381-2386.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2381-2386
    • Knoll, G.A.1    MacDonald, I.2    Khan, A.3
  • 3
    • 33744494308 scopus 로고    scopus 로고
    • Patient-reported gastrointestinal symptom burden and health-related quality of life following conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium
    • Chan L, Mulgaonkar S, Walker R, et al. Patient-reported gastrointestinal symptom burden and health-related quality of life following conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium. Transplantation. 2006;81:1290-1297.
    • (2006) Transplantation , vol.81 , pp. 1290-1297
    • Chan, L.1    Mulgaonkar, S.2    Walker, R.3
  • 4
    • 37349015946 scopus 로고    scopus 로고
    • Improvement in 3-month patientreported gastrointestinal symptoms after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in renal transplant patients
    • Bolin P, Tanriover B, Zibari GB, et al. Improvement in 3-month patientreported gastrointestinal symptoms after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in renal transplant patients. Transplantation. 2007;84:1443-1451.
    • (2007) Transplantation , vol.84 , pp. 1443-1451
    • Bolin, P.1    Tanriover, B.2    Zibari, G.B.3
  • 5
    • 33846230492 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients
    • Staatz CE, Tett SE. Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients. Clin Pharmacokinet. 2007;46:13-58.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 13-58
    • Staatz, C.E.1    Tett, S.E.2
  • 6
    • 25844510767 scopus 로고    scopus 로고
    • Genetic and nongenetic determinants of between-patient variability in the pharmacokinetics of mycophenolic acid
    • Hesselink DA, Gelder T. Genetic and nongenetic determinants of between-patient variability in the pharmacokinetics of mycophenolic acid. Clin Pharmacol Ther. 2005;78:317-321.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 317-321
    • Hesselink, D.A.1    Gelder, T.2
  • 7
    • 0037306174 scopus 로고    scopus 로고
    • Acyl glucuronide drug metabolites; Toxicological and analytical implications
    • Shipkova M, Amstrong VW, Oellerich M, et al. Acyl glucuronide drug metabolites; toxicological and analytical implications. Ther Drug Monit. 2003;25:1-16.
    • (2003) Ther Drug Monit , vol.25 , pp. 1-16
    • Shipkova, M.1    Amstrong, V.W.2    Oellerich, M.3
  • 8
    • 35348836649 scopus 로고    scopus 로고
    • C-440/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation
    • Badelli S, Merlini S, Perico N, et al. C-440/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation. Pharmacogenomics. 2007;8:1127-1141.
    • (2007) Pharmacogenomics , vol.8 , pp. 1127-1141
    • Badelli, S.1    Merlini, S.2    Perico, N.3
  • 9
    • 34247225405 scopus 로고    scopus 로고
    • Influence of the UGT2B7 promoter region and exon 2 polymorphisms and comedications on Acyl-MPAG production in vitro and in adult renal transplant patients
    • Djebli N, Picard N, Rerolle JP, et al. Influence of the UGT2B7 promoter region and exon 2 polymorphisms and comedications on Acyl-MPAG production in vitro and in adult renal transplant patients. Pharmacogenet Genom. 2007;17:321-330.
    • (2007) Pharmacogenet Genom , vol.17 , pp. 321-330
    • Djebli, N.1    Picard, N.2    Rerolle, J.P.3
  • 10
    • 11144318750 scopus 로고    scopus 로고
    • Identification of the UDPglucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism
    • Picard N, Ratanasavanh D, Premaud A, et al. Identification of the UDPglucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism. Drug Metab Dispos. 2005;33:139-146.
    • (2005) Drug Metab Dispos , vol.33 , pp. 139-146
    • Picard, N.1    Ratanasavanh, D.2    Premaud, A.3
  • 12
    • 33750346955 scopus 로고    scopus 로고
    • Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients
    • Naesens M, Kuypers DRJ, Verbeke K, et al. Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients. Transplantation. 2006;82:1074-1084.
    • (2006) Transplantation , vol.82 , pp. 1074-1084
    • Naesens, M.1    Kuypers, D.R.J.2    Verbeke, K.3
  • 13
    • 39049184100 scopus 로고    scopus 로고
    • Characterisation of intestinal absorption and enterohepatic circulation of mycohenolic acid and its 7-o-glucuronide in rats
    • Saitoh H, Kobayashi M, Oda M, et al. Characterisation of intestinal absorption and enterohepatic circulation of mycohenolic acid and its 7-o-glucuronide in rats. Drug Metab Pharmacokinet. 2006;21:406-413.
    • (2006) Drug Metab Pharmacokinet , vol.21 , pp. 406-413
    • Saitoh, H.1    Kobayashi, M.2    Oda, M.3
  • 15
    • 4444369519 scopus 로고    scopus 로고
    • Identification of protein targets for mycophenolic acid acyl gluconide in rat liver and colon tissue
    • Shipkova M, Beck H, Voland A, et al. Identification of protein targets for mycophenolic acid acyl gluconide in rat liver and colon tissue. Proteomics. 2004;4:2728-2738.
    • (2004) Proteomics , vol.4 , pp. 2728-2738
    • Shipkova, M.1    Beck, H.2    Voland, A.3
  • 16
    • 33847659653 scopus 로고    scopus 로고
    • The Impact of UGT1A8 UGT1A9 and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers
    • Levesque E, Delage R, Benoit-Biancamano M-O, et al. The Impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers. Clin Pharmacol Ther. 2007;81:392-400.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 392-400
    • Levesque, E.1    Delage, R.2    Benoit-Biancamano, M.-O.3
  • 17
    • 33747830531 scopus 로고    scopus 로고
    • Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid
    • Bernard O, Tojcic J, Jorunault K, et al. Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid. Drug Metab Disposit. 2006;34:1539-1545.
    • (2006) Drug Metab Disposit , vol.34 , pp. 1539-1545
    • Bernard, O.1    Tojcic, J.2    Jorunault, K.3
  • 18
    • 33846230114 scopus 로고    scopus 로고
    • Genetic susceptibility to diclofenac-induced hepatotoxicity: Contribution of UGT2B7 CYP2C8 and ABCC2 genotypes
    • Daly AK, Aithal GP, Leathart JBS, et al. Genetic susceptibility to diclofenac-induced hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 genotypes. Gastroenterology. 2007;132:272-281.
    • (2007) Gastroenterology , vol.132 , pp. 272-281
    • Daly, A.K.1    Aithal, G.P.2    Leathart, J.B.S.3
  • 19
    • 33846012498 scopus 로고    scopus 로고
    • Irinotecan-induced diarrhea: Functional significance of the polymorphic ABCC2 transporter protein
    • Jong FA, Scott-Horton TJ, Kroetz DL, et al. Irinotecan-induced diarrhea: Functional significance of the polymorphic ABCC2 transporter protein. Clin Pharmacol Ther. 2007;81:42-49.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 42-49
    • Jong, F.A.1    Scott-Horton, T.J.2    Kroetz, D.L.3
  • 20
    • 0035103009 scopus 로고    scopus 로고
    • Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
    • Ito S, Ieiri I, Tanabe M, et al. Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects. Pharmacogenetics. 2001;11:175-184.
    • (2001) Pharmacogenetics , vol.11 , pp. 175-184
    • Ito, S.1    Ieiri, I.2    Tanabe, M.3
  • 21
    • 0036206860 scopus 로고    scopus 로고
    • Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: An association between single nucleotide polymorphisms in the 5'-untranslated region and exon 28
    • Itoda M, Saito Y, Soyama A, et al. Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5'-untranslated region and exon 28. Drug Metab Dispos. 2002;30:363-364.
    • (2002) Drug Metab Dispos , vol.30 , pp. 363-364
    • Itoda, M.1    Saito, Y.2    Soyama, A.3
  • 22
    • 33750587517 scopus 로고    scopus 로고
    • Using GI-specific patient outcome measures in renal transplant patients: Validation of the GSRS and GIQLI
    • Kleinman L, Kilburg A, Machnicki G, et al. Using GI-specific patient outcome measures in renal transplant patients: Validation of the GSRS and GIQLI. Qual Life Res. 2006;15:1223-1232.
    • (2006) Qual Life Res , vol.15 , pp. 1223-1232
    • Kleinman, L.1    Kilburg, A.2    MacHnicki, G.3
  • 23
    • 67349228216 scopus 로고    scopus 로고
    • Effects of abdominal massage in management of constipation- A randomized controlled trial
    • Lamas K, Lindholm L, Stenlund H, et al. Effects of abdominal massage in management of constipation- A randomized controlled trial. Internat J Nurs Stud. 2009;46:759-767.
    • (2009) Internat J Nurs Stud , vol.46 , pp. 759-767
    • Lamas, K.1    Lindholm, L.2    Stenlund, H.3
  • 24
    • 49249096084 scopus 로고    scopus 로고
    • Gastrointestinal (GI)-specific patient reported outcomes instruments differentiate between renal transplant patients with or without GI symptoms: Results from a South American Cohort
    • Machnicki G, Pefaur J, Gaite L, et al. Gastrointestinal (GI)-specific patient reported outcomes instruments differentiate between renal transplant patients with or without GI symptoms: results from a South American Cohort. Health Qual Life Outcomes. 2008;6:53-62.
    • (2008) Health Qual Life Outcomes , vol.6 , pp. 53-62
    • MacHnicki, G.1    Pefaur, J.2    Gaite, L.3
  • 25
    • 34250159809 scopus 로고    scopus 로고
    • Plasma concentrations of mycophenolic acyl glucuronide are not associated with diarrhea in renal transplant recipients
    • Heller T, van Gelder T, Budde K, et al. Plasma concentrations of mycophenolic acyl glucuronide are not associated with diarrhea in renal transplant recipients. Am J Transplant. 2007;7:1822-1831.
    • (2007) Am J Transplant , vol.7 , pp. 1822-1831
    • Heller, T.1    Van Gelder, T.2    Budde, K.3
  • 26
    • 1342325540 scopus 로고    scopus 로고
    • Enteric-coated mycophenolate sodium can be safely administered in maintenance renal transplant patients: Results of a 1-year study
    • Budde K, Curtis J, Knoll G, et al. Enteric-coated mycophenolate sodium can be safely administered in maintenance renal transplant patients: results of a 1-year study. Am J Transplant. 2004;4:237-243.
    • (2004) Am J Transplant , vol.4 , pp. 237-243
    • Budde, K.1    Curtis, J.2    Knoll, G.3
  • 27
    • 17644413799 scopus 로고    scopus 로고
    • Mycophenolate sodium does not reduce the incidence of GI adverse events compared with mycophenolate mofetil
    • Meier-Kriesche HU, Davies NM, Grinyo J, et al. Mycophenolate sodium does not reduce the incidence of GI adverse events compared with mycophenolate mofetil. Am J Transplant. 2005;5:1164-1166.
    • (2005) Am J Transplant , vol.5 , pp. 1164-1166
    • Meier-Kriesche, H.U.1    Davies, N.M.2    Grinyo, J.3
  • 28
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics-drug disposition, drug targets, and side effects
    • Evans WE, McLeod HL. Pharmacogenomics-drug disposition, drug targets, and side effects. New Eng J Med. 2003;348:538-549.
    • (2003) New Eng J Med , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.