Antibiotics in Periodontics: Right or Wrong?

Journal of Periodontology

Volumn 80, Issue 10, 2009, Pages 1555-1558

  Van Winkelhoff, Arie J ^a   Winkel, Edwin G ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; METRONIDAZOLE;

BACTEROIDACEAE INFECTION; DRUG COMBINATION; HUMAN; ISOLATION AND PURIFICATION; MICROBIOLOGY; MULTIMODALITY CANCER THERAPY; NOTE; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PREVENTIVE DENTISTRY; TOOTH PLAQUE; TREATMENT OUTCOME;

AMOXICILLIN; ANTI-BACTERIAL AGENTS; BACTEROIDACEAE INFECTIONS; COMBINED MODALITY THERAPY; DENTAL PLAQUE; DENTAL SCALING; DRUG COMBINATIONS; HUMANS; METRONIDAZOLE; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL POCKET; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; ROOT PLANING; TREATMENT OUTCOME;

EID: 70349656552     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2009.090276     Document Type: Note

References (18)

1. van Winkelhoff AJ, Rams TE, Slots J. Systemic antibiotic therapy in periodontics. Periodontol 2000 1996; 10:45-78.
2. Herrera D, Sanz M, Jepsen S, Needleman I, Roldán S. A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 2002; 29(Suppl. 3):136-159.
3. Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 2003;8:115-181.
4. van Winkelhoff AJ, Tijhof CJ, de Graaff J. Microbiological and clinical results of etronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans associated periodontitis. J Periodontol 1992; 63:52-57.
5. Winkel EG, van Winkelhoff AJ, Timmerman MF, Van der Velden U, Van der Weijden GA. Metronidazole plus amoxicillin in the treatment of adult periodontitis: A double blind placebo-controlled study. J Clin Periodontol 2001;28:296-305.
6. Guerrero A, Griffiths GS, Nibali L, et al. Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: A randomized placebo-controlled clinical trial. J Clin Periodontol 2005;32:1096 1107.
7. Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Amoxicillin and metronidazole as an adjunct to fullmouth scaling and root planing of chronic periodontitis. J Periodontol 2009;80:364-371.
8. Winkel EG, van Winkelhoff AJ, Van der Velden U. Additional clinical and icrobiological effects of amoxicillin and metronidazole after initial periodontal therapy. J Clin Periodontol 1998;25:857-864.
9. Takamatsu N, Yano K, He T, Umeda M, Ishikawa I. Effect of initial periodontal therapy on the frequency of detecting Bacteroides forsythus, Porphyromonas gingivalis, and Actinobacillus actinomycetemcomitans. J Periodontol 1999; 70:574-580.
10. Eberhard J, Jepsen S, Jervøe-Storm PM, Needleman I, Worthington H. Full-mouth disinfection for the treatment of adult chronic periodontitis. Cochrane Database Syst Rev 2008;CD004622.
11. Loesche WJ, Giordano JR, Hujoel P, Schwarcz J, Smith BA. Metronidazole in periodontitis: Reduced need for surgery. J Clin Periodontol 1992;19:103-112.
12. Haffajee AD. Systemic antibiotics: To use or not use in the treatment of periodontal infections. That is the question. J Clin Periodontol 2006;33:359-361.
13. van Winkelhoff AJ. Antibiotics in periodontics: Are we getting somewhere? J Clin Periodontol 2005;32:1094-1095.
14. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque J Clin Periodontol 1998;25:134-144.
15. van Winkelhoff AJ, Loos BG, van der Reijden WA, Van der Velden U. orphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction. J Clin Periodontol 2002;29:1023-1028.
16. Haffajee AD, Torresyap G, Socransky SS. Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results. J Clin Periodontol 2007;34:243-253.
17. Sigusch B, Beier M, Klinger G, Pfister W, Glockmann E. A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis. J Periodontol 2001;72: 275-283.
18. Winkel EG, van Winkelhoff AJ, Barendregt DS, Van der Weijden GA, Timmerman MF, Van der Velden U. Clinical and microbiological effects of initial periodontal therapy in conjunction with amoxicillin and clavulanic acid in patients with adult periodontitis. A randomised double-blind, placebocontrolled study. J Clin Periodontol 1999;26:461-468.