Geography, structure, and evolution of diffusion and perfusion lesions in diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE)

Stroke

Volumn 40, Issue 10, 2009, Pages 3245-3251

  Olivot, Jean Marc ^a   Mlynash, Michael ^a   Thijs, Vincent N ^b,c   Purushotham, Archana ^a   Kemp, Stephanie ^a   Lansberg, Maarten G ^a   Wechsler, Lawrence ^d,e   Gold, Garry E ^d,e   Bammer, Roland ^d,e   Marks, Michael P ^d,e   Albers, Gregory W ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain infarction; Magnetic resonance; Thrombolysis

Indexed keywords

ACCURACY; ADULT; ARTICLE; BLOOD CLOT LYSIS; BRAIN DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; EVOLUTION; FIBRINOLYTIC THERAPY; FOLLOW UP; GEOGRAPHY; HUMAN; INFARCTION; OUTCOME ASSESSMENT; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

AGED; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; DIFFUSION MAGNETIC RESONANCE IMAGING; DISEASE PROGRESSION; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; OUTCOME ASSESSMENT (HEALTH CARE); REPERFUSION INJURY; STROKE; TREATMENT OUTCOME;

EID: 70349653317     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.109.558635     Document Type: Article

References (16)

1. Chalela JA, Kidwell CS, Nentwich LM, Luby M, Butman JA, Demchuk AM, Hill MD, Patronas N, Latour L, Warach S. Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet. 2007;369: 293-298.
2. Donnan GA, Baron JC, Ma H, Davis SM. Penumbral selection of patients for trials of acute stroke therapy. Lancet Neurol. 2009;8:261-269.
3. Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, Bammer R, Kakuda W, Lansberg MG, Shuaib A, Coplin W, Hamilton S, Moseley M, Marks MP. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the Diffusion and perfusion imaging Evaluation For Understanding Stroke Evolution (DEFUSE) study. Ann Neurol. 2006;60:508-517.
4. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, Barber PA, Bladin C, De Silva DA, Byrnes G, Chalk JB, Fink JN, Kimber TE, Schultz D, Hand PJ, Frayne J, Hankey G, Muir K, Gerraty R, Tress BM, Desmond PM. Effects of alteplase beyond 3 h after stroke in the EchoPlanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol. 2008;7:299-309.
5. Olivot JM, Mlynash M, Thijs VN, Kemp S, Lansberg MG, Wechsler L, Schlaug G, Bammer R, Marks MP, Albers GW. Relationships between infarct growth, clinical outcome, and early recanalization in Diffusion and perfusion imaging Evaluation For Understanding Stroke Evolution (DEFUSE). Stroke. 2008;39:2257-2263.
6. Kidwell CS, Alger JR, Saver JL. Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke. 2003;34:2729-2735.
7. Schlaug G, Benfield A, Baird AE, Siewert B, Lovblad KO, Parker RA, Edelman RR, Warach S. The ischemic penumbra: operationally defined by diffusion and perfusion MRI. Neurology. 1999;53:1528-1537.
8. Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, Gillard JH, Williams GB, Aigbirhio FI, Warburton EA, Ostergaard L, Baron JC. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET. Stroke. 2008;39:870-877.
9. Olivot JM, Mlynash M, Zaharchuk G, Straka M, Bammer R, Schwartz N, Lansberg MG, Moseley ME, Albers GW. Perfusion MRI (Tmax and MTT) correlation with xenon CT cerebral blood flow in stroke patients. Neurology. 2009;72:1140-1145.
10. Olivot JM, Mlynash M, Thijs VN, Kemp S, Lansberg MG, Wechsler L, Bammer R, Marks MP, Albers GW. Optimal Tmax threshold for predicting penumbral tissue in acute stroke. Stroke. 2009;40:469-475.
11. Kidwell CS, Saver JL, Mattiello J, Starkman S, Vinuela F, Duckwiler G, Gobin YP, Jahan R, Vespa P, Kalafut M, Alger JR. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol. 2000;47:462-469.
12. Purushotham A, Mlynash M, Olivot J-M, Thijs VN, Bammer R, Kemp SM, Albers GW, Lansberg MG. Apparent diffusion coefficient distinguishes ischemic core from reversible diffusion lesions [Abstract]. Stroke. 2009; 40:e115.
13. Guadagno JV, Warburton EA, Jones PS, Day DJ, Aigbirhio FI, Fryer TD, Harding S, Price CJ, Green HA, Barret O, Gillard JH, Baron JC. How affected is oxygen metabolism in DWI lesions? A combined acute stroke PET-MR study. Neurology. 2006;67:824-829.
14. Olivot JM, Mlynash M, Thijs VN, Purushotham A, Kemp S, Lansberg MG, Wechsler L, Bammer R, Marks MP, Albers GW. Relationships between cerebral perfusion and reversibility of acute diffusion lesions in DEFUSE: insights from RADAR. Stroke. 2009;40:1692-1697.
15. Wu O, Christensen S, Hjort N, Dijkhuizen RM, Kucinski T, Fiehler J, Thomalla G, Rother J, Ostergaard L. Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI. Brain. 2006;129:2384-2393.
16. Rosso C, Hevia-Montiel N, Deltour S, Bardinet E, Dormont D, Crozier S, Baillet S, Samson Y. Prediction of infarct growth based on apparent diffusion coefficients: penumbral assessment without intravenous contrast material. Radiology. 2009;250:184-192.